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Biomedical subjects

S Kunz

Publications and source records attributed to S Kunz.

At least 73 records · Page 4Linked to original sources
PubMed1978

Studies on platelet function during different modes of administration of PgF2alpha in obstetrics and gynecology.

Platelet function has been studied during intravenous, intraamniotic, and extraamniotic administration of prostaglandin F2alpha (PgF2alpha) for termination of missed abortion and missed labor, for therapeutic abortion, and for induction of term labor. The controls received oxytocin i.v. (missed labor and term labor). Our investigations have shown that there was a normalization of the increased spontaneous platelet aggregation and a significant reduction of ADP- and collagen-induced platelet aggregation in the groups given PgF2alpha i.v. The desaggregation in these groups was increased. The other groups given PgF2alpha showed no significant changes in platelet function. Inducing labor by oxytocin we found a tendency to increased platelet aggregation and decreased desaggregation. The clinical importance of these findings and the consequences for hemostasis are discussed.

Abortion, Missed↗
PubMed1978

[Platelet function during long term inhibition of labour by fenoterol/verapamil (author's transl)].

Platelet function has been studied in 22 patients (methods according to Born and Breddin) during tocolysis with long term administration of intravenous Fenoterol/Verapamil. The extend and speed of platelet aggregation, according to the Born test, were constant in the following 12 days except for a small increase on the second day. The phase of disaggregation remained unchanged. The reaction time to collagen was prolonged up to the 3rd-4th day. Spontaneous platelet aggregation showed a tendency to decrease up to day 3--4; thereafter, there was a return to the original values. The present data show that a hemostatic action in platelet function cannot be expected during long term tocolysis. Thus, there is no evidence that Fenoterol acts as an inhibitor of platelet aggregation in pregnancy.

Blood Platelets↗
PubMed1978

[Fetal parasystolia--uncommon case of fetal arrhythmia with polyhydramnios and hydrops fetalis (author's transl)].

By direct fetal electrocardiography an arrhythmic pattern comparable with parasystolia was observed during the 38th week of pregnancy. The gestational course was only complicated by polyhydramnios. The record of the FHF was considerably disturbed. The normocardic pattern showed poor irregularity, rarely accelerations and decelerations during labor activity. The ectopic QRS-complex was broadened (0,06--0,08 sec) and frequently raised. Beginning the record the frequency of the parasystolia was lower than the activity of the sinus node. A hydropic neonate was delivered by vacuum and died after bradyarrhythmia 37 minutes after parturition. In spite of intensive clarification the cause of pathology was not detected.

Adult↗
PubMed1978

[Thrombocyte aggregation after abdominal hysterectomy with combined prevention of thromboembolism using 6% macrodex and sintrom].

Thrombocyte aggregation was investigated, according to Born, in 14 patients who underwent abdominal hysterectomy due to benign illness. The patients received dextran 60 and 4-hydroxycoumarin as prophylactic therapy for early and late thromboembolism. The following results were obtained: 1. The ability of the thrombocytes to aggregate was reduced by half, 2 hours postoperatively, after administration of dextran 60, and remained at this level during the first postoperative day. This action was independent of the concentration and type of agent used in the aggregation test. The original values were attained again on the 4th postoperative day. The speed and force of desaggregation showed reverse behaviour. 2. Results bore no relationships to the age of the patient. 3. This combined prophylactic therapy with macrodex (500 ml intraoperatively) and sintrom (from the 1st postoperative day) seems to give adequate protection in both the intra- and postoperative risk phases.

4-Hydroxycoumarins↗
PubMed1978

[Thrombocyte aggregation after vaginal hysterectomy with combined prevention of thromboembolism with macrodex 6% and sintrom].

The ADP- and collagen-induced thrombocyte aggregation has been investigated and statistically evaluated in 25 women. These patients had undergone vaginal hysterectomy and colporrhaphy due to descensus vaginae et uteri and received 500 ml Macrodex 6% during the operation and Sintrom from the 1st post-operative day as prophylactic treatment for early and late thromboembolism. After administration of dextran 60, the ability of the thrombocytes to aggregate was reduced by half, 2 hours post-operatively, independent of the concentration and type of agent added in the aggregation test, and remained at this level during the 1st post-operative day. The original values were once again attained on the 4th post-operative day. The speed and force of deaggregation showed reverse behaviour. There was no influence apparent due to age of the patient or phase of the cycle (proliferation, secretion and post-menopausal). By carrying out this combined prophylactic treatment for thromboembolism, satisfactory protection is provided in the dangerous phases during the operation and post-operatively.

Acenocoumarol↗
PubMed1978

[Influence on haemostasis exercised by Prostaglandin F2alpha in missed abortion (author's transl)].

The changes in the coagulation and the fibrinolytic system which may be related to the dead fetus syndrome indicate an interference of the activation of both coagulation and fibrinolysis. During termination of missed abortion and missed labour disorders of the haemostasis may occur acutely. In 16 patients with intrauterine death coagulation studies were performed inducing labour with PgF2alpha intraamniotically or i.v. No essentiel changes in the plasmatic system of coagulation and fibrinolysis were found. After i.a. application of PgF2alpha, the ADP- and collagen-induced as well as the spontaneous platelet aggregation didn't change. Using PgF2alpha i.v. a diminuation of the initially increased platelet aggregation was found in all parameters, whereas desaggregation was increased. These changes may influence an already existing latent consumption of coagulation factors in a favourable way. A further advantage of prostaglandins consists in the fact that smaller traumata occur, compared with curettage, so the possibility of liberation of thrombo-plastic material is reduced.

Abortion, Missed↗
PubMed1978

[Changes of platelet function, coagulation and fibrinolysis during induction of labour at term by prostaglandin F2alpha and oxytocin (author's transl)].

Platelet function (induced and spontaneous aggregability according to Born and Breddin respectively) and some parameters of coagulation and fibrinolysis have been investiagted during induction of term labour by PgF2alpha i.v. (n = 9) and oxytocin i.v. (n = 9). During infusion of PgF2alpha there was a slight decrease of platelet aggregation with both methods. Desaggregation in the Born-test was increased. On the contrary there was no change of platelet function except a small increase of the speed of aggregation if one applicates oxytocin. The parameters of the plasmatic coagulation system remained almost unchanged in both groups and hint only at a slight increase of the fibrinolytic activity in the oxytocin group. The clinical importance of the results is discussed.

Blood Coagulation↗
PubMed1977

[Coagulation-physiological studies on the prevention of thromboembolism with dextran 60. I. The effect on platelet function].

Platelet aggregation, spreading capacity, adhesiveness (methods according to BREDDIN) have been investigated in 3 groups of 20 patients each after gynecological surgery. Group A (control group) got only 4-hydroxycumarin (Sintrom), group B--in addition to that--intraoperative 500 ml Dextran 60 (Macrodex 6%), group C 500 ml Dextran 60 as well intraoperative as on the 1., 2., 4., 7. and 10. day after surgery. The present data show that depending on the duration of Dextran application, platelet spreading capacity and adhesiveness are inhibited differently as to duration and extent. There was, above all, a reduction and with that a normalisation of the postoperatively increased spontaneous platelet aggregation. It is possible to influence the phase of early postoperative embolism in a favorable way by applicating Dextran already intraoperatively. After that one can use further infusions of Dextran, a prophylaxis by Cumarins or other anticoagulants. Giving dextran only once during surgery one can prove this normalisation of the increased platelet aggregation up to 24 hours postoperatively. By further infusions of Dextran 60 on the 1., 2., 4., 7. and 10. postoperative day it is possible to keep the extent of aggregation on a significantly reduced level till the complete mobilisation of the patient and consequently attain a protective effect on a possible development of deep venous thrombosis of the legs.

Cell Count↗
PubMed1977

[Coagulation-physiological studies on the prevention of thromboembolism with dextran 60. II. Changes in coagulation and fibrinolysis].

The postoperative behavior of different parameters of coagulation and fibrinolysis have been studied in three groups of 20 patients each. Group A got only 4-hydroxycumarin, group B 500 ml Dextran 60 intraoperatively in addition to that, group C 500 ml Dextran 60 during surgery and on the 1., 2., 4., 7. and 10. postoperative day. The results show that the hypercoagulability which occurs immediately after surgery can be prevented by infusion of Dextran 60. On the other hand there is no evidence that Dextran 60 may cause a consumptive coagulability. There is only little influence on fibrinolysis, so that no defect of haemostasis can be expected. So it is possible to use Dextran 60 both for bridging over the phase of early embolism after surgery until the change to other anticoagulants and as a substance which can be applicated for a longer period of time in prophylaxis of thromboembolism. It is referred to the additional properties of Dextran 60 in prevention of thrombosis due to reduction of blood viscosity and improvement of microcirculation.

4-Hydroxycoumarins↗
PubMed1976

[The psychological results of tubal ligation as definitive method of contraception (author's transl)].

The cases of tubal ligation at the University Department of Tubingen and the University Department of Giessen during the last few years were reviewed. In most cases the psychological results of the procedure is positive and results in an improved partner relationship in most cases, provided that the procedure was the result of a mature decision by the couple. Tubal ligation in the puerperium is more favorable than in conjunction with the Caesarean Section. Interval sterilization shows the best results. A thorough discussion by the physician and if possible a psychological discussion should take place prior to the tubal ligation since both are important aids in the decision. The social indication should be clearly defined and the responsibility of the couple should be emphasized. A well defined and documented task for the clinical practice of prior physician and psychological discussion of tubal ligation is the basis of a present prospective study at the University Department for Women in Tubingen which is designed to show the positive psychological effects on the couple.

Adult↗