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Biomedical subjects

S Kumar

Publications and source records attributed to S Kumar.

At least 1,459 records · Page 81Linked to original sources
PubMed1993

Dermatoglyphics in congenital profound sensorineural hearing loss: a disease marker?

A dermatoglyphic profile was carried out in 108 cases of congenital profound sensorineural hearing loss (SNHL) with delayed development of speech and language (DDSL). Rolled finger prints and palmar patterns were obtained by the ink method and analysed by the Galton system. In the genetic group (Group A) triradii 6 was present whereas it was absent in the nongenetic (Group B) group and their controls (p < 0.001). Loop pattern in interdigital areas did not vary significantly from controls. The average 'atd' angle in Group A was 41 degrees and that in the Group B was 46 degrees (p > 0.5). Ulnar loops predominated over the radial loops. Absence of CPW on thumbs of Group A was noted. Total ridge count in the Group A was 98.84 and 109 in the Group B (p < 0.05). It was observed that no definite pattern existed in a constant fashion and it also exhibited a great degree of variation, hence their role in detection of hearing loss is questionable.

Adolescent↗
PubMed1993

Desferrioxamine induced urinary iron excretion in thalassemia.

Twenty one children of beta thalassemia major aged between 2 and 14 years of age on regular blood transfusion were given subcutaneous desferrioxamine. Their serum ferritin, 24 hours baseline urinary iron excretion and subcutaneous desferrioxamine induced urinary iron excretion were measured. The result showed a close correlation between serum ferritin and amount of blood transfusions received by the patient. There was good correlation between serum ferritin and desferrioxamine induced urinary iron excretion. A negative iron balance could be achieved in 15 out of 21 children with one dose of desferrioxamine therapy.

Adolescent↗
PubMed1993

"Parthenium dermatitis: an unsuspected allergy".

Congress grass (Parthenium hysterophorus) is a common weed growing wild in the urban and semiurban environs of North India. Cases of eczematous dermatitis caused by it generally escape clinical detection and are consequently wrongly diagnosed. An interesting case of Parthenium dermatitis treated with a high-dose course of desensitisation is presented to underscore the probability of the entity in obscure cases of contact dermatitis and eczema.

Dermatitis↗
PubMed1993

Expression of GTP-binding protein gene drg during Xenopus laevis development.

To study the genes which may play a role in the development of the vertebrate central nervous system (CNS) using a subtraction cloning approach, we previously identified a set of novel genes which are predominantly expressed in the mouse embryonic CNS and down-regulated during development. One of these genes, drg, encodes a novel 41 kilodalton GTP-binding protein (DRG), which is highly expressed in the embryonic CNS and shows remarkable evolutionary conservation. To study the biological role of this protein during Xenopus embryonic development, we cloned the Xenopus drg cDNA (Xdrg). The predicted Xenopus DRG protein (XDRG) is more than 95% identical to the mouse DRG. Analysis of Xdrg expression by Northern blots, whole-mount in situ hybridization and RNA-PCR revealed the presence of varying levels of transcript for this gene in embryos and adult tissues. Among the three mRNA species detected by Northern hybridization, two smaller ones show temporally regulated expression patterns during embryonic development.

Amino Acid Sequence↗
PubMed1993

Monitoring the adverse profile of atenolol--a collaborative study.

Atenolol, a cardio selective beta-adrenergic blocker, frequently prescribed in various cardiac ailments, has not been thoroughly investigated for its adverse reaction profile in Indian patient. The present ADR monitoring study which was open, prospective and collaborative was therefore planned. A total of 440 patients with various heart disease were enrolled after a strict inclusion and exclusion criteria from Maulana Azad Medical College, New Delhi and J.N. Medical College, Aligarh. fifteen patients dropped out leaving 435 for final analysis. Cold extremities occurred in 1.18% headache and dizziness in 1.41% breathlessness in 0.94% oedema in 0.70% and bradycardia in 0.47%. Adverse drug reaction in our study were less than those reported from Western countries. Better patient selection, optimal dose could have reduced the frequency of ADR in the present study. Racial factor and season might be operating to bring down ADR to atenolol in Indian patients.

Atenolol↗
PubMed1993

Mycological aspects of dermatomycosis in Ludhiana.

159 clinically diagnosed cases of dermatomycosis were examined and subjected to mycological study. In the direct microscopic examination, 78 (49.05%) cases were positive and cultures were positive in 66 (41.5%) cases. The common clinical presentation was T. corporis in 60 (37.7%) cases. The commonest species encountered was T. rubrum (42.42%) followed by Epidermophyton floccusum (15.15%), Candida (13.63%), T. violaceum (12.12%), T. mentagrophyte (6.06%) & T. tonsurans (1.5%) in this study. The prevalence of infection was more in males.

Adolescent↗
PubMed1993

Plasma lipoproteins in cortical and lacunar infarction.

Plasma lipoproteins in 30 patients of cortical infarction and 20 patients of lacunar infarction were estimated to study the relation of plasma lipids to the risk for ischaemic stroke by comparing clinical and biochemical characteristics of survivors. No significant differences were observed in the concentrations of total cholesterol, triglycerides, low density lipoproteins, very low density lipoproteins in both the groups. However patients with lacunar infarction had higher concentrations of high density lipoproteins as compared to patients with cortical infarction. These data suggest that previously demonstrated differences in HDL concentration between patients with ischaemic stroke and control subjects without stroke may be true for patients with cortical infarction but not for patients of lacunar infarction.

Adult↗
PubMed1993

In-vivo and in-vitro sensitivity of Plasmodium falciparum to chloroquine at Indian Oil Corporation, Mathura (U.P.).

In vivo and in vitro susceptibility of Plasmodium falciparum to chloroquine were conducted at Indian Oil Corporation (IOC), Mathura, India. 18 out of 31 cases showed resistance [minimum inhibitory concentration (MIC) 8 pmol] in in vitro study. EC50 and EC90 values estimated from log-probit analysis for resistant isolates were 0.66 and 1.44 microM/litre, and for sensitive isolates 0.28 and 0.96 microM/litre blood respectively. In vivo tests identified 13 cases (40.62%) as resistant and 19 cases (59.73%) as sensitive out of 32 cases. All the cases belonged to IOC, Mathura complex, or its vicinity.

Animals↗
PubMed1993

Comparison of caudal morphine and buprenorphine for post-operative analgesia in children.

Sixty five children aged from 1-10 years who underwent herniotomy, cystolithotomy or orchidopexy received either buprenorphine 4 micrograms kg-1 (n = 33) or morphine 50 micrograms kg-1 (n = 32) by the caudal epidural route; each thus received 0.5 ml kg-1 body weight. General anaesthesia was given for surgery. Post-operative pain and behaviour were assessed by an independent observer at 1, 4, 8, 16 and 24 h post-operatively. Caudal morphine and buprenorphine were equally effective for post-operative analgesia in children, but buprenorphine was better because of its longer duration of action and lower incidence of side effects.

Anesthesia, Caudal↗
PubMed1993

Immunocytochemical detection of prolactin binding sites in fine needle aspiration smears of breast lesions.

Specific prolactin (PRL) binding sites were demonstrated in the fine needle aspiration cytology (FNAC) specimens from 68 patients with benign and malignant diseases of the breast using highly sensitive technique of DNP hapten sandwich staining procedure and antibody against human PRL. In 16 patients, immunocytochemical staining was also carried out on paraffin embedded sections of corresponding lesions. FNAC specimens included 52 neoplasms and 16 non-proliferative and proliferative benign breast disease. The reaction varied in different lesions, being maximum (72%) in malignant tumours and 60 per cent in benign tumours. However, benign breast disease showed a reaction that varied with the lesion. The technique was found to be simple, sensitive and economical for demonstrating specific PRL binding sites in cytology specimens of breast lesions.

Binding Sites↗