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Biomedical subjects

S Kulkarni

Publications and source records attributed to S Kulkarni.

178 records · Page 10Linked to original sources
PubMedDate not supplied

A comparison of EMG and SCL in normal and depressed subjects.

Skin conductance level (SCL) and electromyograms (EMGs) recorded from three muscle sites were compared for 15 female hospitalized psychiatric patients meeting diagnostic criteria for primary affective disorder and 15 age-and race-matched controls. The depressed subjects had significantly lower SCL and significantly higher resting EMG levels recorded from one muscle site. Electromyogram and SCL were not found to be significantly correlated with each other or with measures of anxiety or depression for the patients with primary affective disorder. Normal controls, however, showed significant correlations between a measure of depression and both EMG and SCL. These results are discussed with suggestions for future research.

Adult↗
PubMedDate not supplied

Reaction of trimethylsilylimidazole with 5,10 beta-epoxy-3-ketosteroids: enolization and aromatization of the A-ring.

The reaction of trimethylsilylimidazole (TSIM) and 3-keto-5,10-epoxy-nor-19-methylandrostanone 3 and its 17-acetate analog 4 was examined at two different temperatures. In both compounds, reaction at 90 degrees C gave predominantly a delta 3-silyl-enol ether plus a minor product as a result of the epoxide ring opening. Under reflux conditions, besides the aforementioned products, aromatization of the A-ring was observed as a major process. The results suggest the potential use of silylation reactions with epoxyketones towards the synthesis of aromatic compounds.

Androstanes↗
PubMedDate not supplied

Irreducible lateral dislocation of the elbow.

A rare case of an irreducible post-traumatic lateral dislocation of elbow is presented. The mechanism of injury was fall on a flexed elbow with trauma on its medial aspect resulting in pronation of the forearm. At open reduction, the brachialis muscle was in the form of a tight band which prevented reduction. The ulnar nerve was entrapped in the joint.

Accidental Falls↗
PubMedDate not supplied

Patients' recollection of day case knee arthroscopy procedure.

A prospective study of 103 consecutive patients who underwent day case knee arthroscopy was performed. The purpose was to evaluate the information delivery system, patient comprehension, and issues of informed consent pertaining to day case arthroscopy procedures. There were 34 females and 69 males in the study group and their mean age was 38.6 years (range: 14.4 to 74.9 years). The diagnosis, procedure, and aftercare were explained to the patients in the outpatients clinic by a trained nurse and by the operating surgeon just prior to the operation. The nurse before the operation gave the patients an information booklet. Postoperatively the patients were informed about the findings and diagnosis prior to their discharge from the day care facility. Patients were requested to complete a questionnaire. Three weeks later they were given the same questionnaire, prior to consultation, in the outpatient clinic. These two forms were compared with the operative findings and diagnosis documented in the copy, of the questionnaire completed by the surgeon as well as the case notes. Most patients (38.8%; 40 patients) had no recollection; 3.9% (4 patients) had partial recollection at their consultation three weeks later; 19.4% (20 patients) found that the arthroscopic photograph was not helpful in making them understand the procedure; and 9.7% (10 patients) found the information booklet to be unhelpful. Further, 23.3% (24 patients) said that it would not help if the booklet were sent to them prior to the operation. The recollection rate was also correlated to their position on the operating list, to ascertain the effect of the anesthetic. There was a 65.9% (58 patients) recollection rate in those patients who were on the first half of the list and there was only a 33.33% recollection rate in those patients who were last or second to the last [p = 0.0225]. We recommend regular evaluation and improvement in the communication and information delivery system provided to patients.

Adolescent↗
PubMedDate not supplied

Reproductive motivation: a comparison of wives and husbands in Maharashtra, India.

This study compares family size preferences, ideal sex compositions, and the motivation underlying these preferences between currently married women and their husbands in a transitional rural society in India. Reasons for having children, though similar, differ in some important respects: women's family size preferences are shaped largely by their dependence on sons for old age and other support; their husbands are affected by this motive as well, but they are also influenced by a desire to continue the family line and perform ritual obligations. However, it is primarily the women who feel the constraints imposed on their time, resources, and other opportunities by large numbers of children, which affect their family size preferences negatively. Finally, both spouses are similarly concerned about the health risks to the mother imposed by frequent childbearing. The net effect of the wives' two opposing motivations results in their having family size desires almost the same as their husbands' desires. As female status improves, the old age security motive is likely to diminish, and concern with utilization of time and resources is likely to become more important, leading ultimately to a reduction in desired family size among women.

Adolescent↗
PubMedDate not supplied

Disposition of salmeterol xinafoate in laboratory animals and humans.

The disposition of [14C]salmeterol xinafoate, a new inhaled beta 2-adrenoceptor agonist with both bronchodilator and antiinflammatory activity, has been studied in laboratory animals and humans following intravenous and oral administration. [14C]Salmeterol was rapidly absorbed in animal species and humans with Cmax observed within 2 hr. Cmax was similar for normalized oral dose level in mice, rats, and rabbits. In dogs, Cmax was higher and reflected the greater oral bioavailability in this species. The plasma t1/2, after intravenous administration, was 5 hr in rats and 2 hr in dogs. The volume of distribution of salmeterol was significantly greater than total body water in both rats (40 liters/kg) and dogs (6 liters/kg) and indicated high tissue uptake of the compound. Plasma clearance was high in rats (95 ml/min/kg) and dogs (30 ml/min/kg). Radioactive drug-related material was widely distributed throughout body tissues in rats. The highest concentrations were present in kidney, liver, gastrointestinal tract, pituitary, lung, heart, and bone marrow. Transfer of radioactive drug-related material across the placental barrier or into milk, studied in rats, was low. In all species the majority of an oral or intravenous dose (55-75%) was excreted in feces. Biliary excretion in rats and dogs accounted for 53% (0-27 hr) and 40% (0-8 hr) of an oral dose, respectively, indicating good absorption across the gastrointestinal tract. Enterohepatic circulation was significant in rats. Salmeterol was cleared predominantly by metabolism in animals and humans.(ABSTRACT TRUNCATED AT 250 WORDS)

Absorption↗