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Biomedical subjects

S Kubicki

Publications and source records attributed to S Kubicki.

At least 55 records · Page 3Linked to original sources
PubMed1980

[Post-traumatic alpha-and mu-wave-foci (author's transl)].

28 patients with an activated focus (8-12 c/s focus) in the central region were examined for mu-wave-activity utilizing visual and calculation of the coherence function. Over 60% (18 patients) of these foci were mu-wave-foci. This type of mu-waves was decidedly less sensitive to change in vigilance than physiological mu-waves. Seven foci were alpha-foci and three foci could be classified as neither alpha- nor mu-wave-foci since they did not react to sensory and sensomotoric stimuli. Furthermore, it was demonstrated that the pathological mu-waves and the pathological alpha-waves were very similar in their characteristics.

Adolescent↗
PubMed1979

Development of a classification rule for four clinical therapeutic psychotropic drug classes with EEG power-spectrum variables of human volunteers.

An objective rule for the classification of psychotropic substances has been developed. Classification is based on data from five basic studies simultaneously designed and performed and involving 75 healthy volunteers who ingested 20 different psychotropic drugs and 5 placebos in single oral dosages. Each volunteer took one psychostimulant, one antidepressant, one neuroleptic, one minor tranquilizer and one placebo in a double-blind Latin square cross-over design. The variables were 6 frequency bands, based on power spectrum estimates and determined by factor analysis, plus total power in the 1.5-30.0 Hz range. An objective classification rule was established by multi-group (5 groups) linear discriminant analysis. Reclassification of the substances by the new rule yielded correct results for 17 out of 20 psychotropic drugs and 4 out of 5 placebos. Of placebos from various studies not used for the establishment of the classification rule, 7/9 were classified correctly. The validity of the rule for other classes of substances will have to be verified in independent studies.

Adult↗
PubMed1979

Reflections on the topics: EEG frequency bands and regulation of vigilance.

A critical analysis of quantitative pharmaco-electroencephalography begins with parametrization into variables. The determination of frequency bands according to clinical criteria should be reconsidered. Alternatives may be the determination of factor scores or the definition of frequency bands based on factor analysis. If the latter procedure is used, the clinical alpha-band is subdivided into a lower (alpha 1F = 8,5-10.5 HZ) and an upper (alpha 2F = 10.5-12.5 HZ) part. Furthermore parts of the clinical theta-band (and the delta-band are combined into the delta F-band (1.5-6.0 HZ), for awake healthy volunteers with an occipital alpha-rhythm. Existing concepts of vigilance for the awake stages are not contradictory to the following observations: the factor structure of EEG relative power spectrum variables shows a negative correlation of slow alpha-frequencies with those in the delta F- and beta 3F-band. There is also a negative correlation between slow and fast alpha-wave relative power values.

Arousal↗
PubMed1979

[Electroencephalographic assessment of dosage and sleep-profile in a hypnotic Triazolothienodiazepine (author's transl)].

We 941, a Triazolodiazepine, has satisfying hypnotic properties. The optimum dosage lies nearly at 0.3 mg. In this dosage the sleep-begin is shortened, the number of nightly wakeness is decreased and the total sleep-time is extended, while the sleep-profile remains unchanged. A normal cycling can be taken as a sign of qualitative good sleep. The REM-percentage is diminished insignificantly and increases again under the continuated therapy. The percentage of deep sleep increases by 0.3 mg. The subjective presentations confirm the melioration of sleep. In higher dosages troubles occur as decrease of deep-sleep stage and deteriorations of feeling. Remarkable is the withdrawal effect after 1.0 mg with an initial and a dissociated REM. However, such strong disturbances couldn't be observed in the carried on therapy with 0.3 mg.

Adult↗
PubMed1979

Electroencephalographic study of pentazocine and buprenorphine.

Both pentazocine and buprenorphine are hypnoanalgetics of the agonistic-antagonist group. They suppress the inhibitory effect of fentanyl upon the central nervous system. They show also secondary their own inhibitory properties (fig. 8). The agonistic-antagonists can be further divided in excitants (like pentazocine) and non-excitants (buprenorphine).

Animals↗
PubMed1978

Abuse of pentazocine.

Explore the source record for details and available documents.

Drug and Narcotic Control↗
PubMed1978

[The mathematical rationale for the clinical EEG-frequency-bands. 1. Factor analysis with EEG-power estimations for determining frequency bands].

In order to determine whether the clinically used frequency bands of the EEG can also be obtained by a mathematical system we did a factor analysis with 480 EEG recordings, 5 minutes each, in 60 healthy male volunteers. A power spectrum analysis was done and 57 frequency bands between 1.5 and 30.0 Hz in a half Hz steps were calculated. The factor structure obtained made the following frequency bands (Hz) reasonable: deltaF = 1.5 - 6.0, thetaF = 6.0 - 8.5, alpha1F = 8.5 - 10.5, alpha2F = 10.5 - 12.5, beta1F = 12.5 - 18.5, beta2F = 18.2 - 21.0, beta3F = 21.0 - 30.0. Except for alpha1F all other 6 frequency bands were represented by one general factor with the complexity 1. The variance of the alpha1F band is explained by several of the 6 factors. The clinically known and the by factor analysis obtained frequency bands in the beta-range are similar. The clinically alpha-band is subdivided into two frequency bands alpha1F and alpha2F by the factor analysis. The clinically known border line between delta- and theta-band of 3.5 Hz cannot be found by factor analysis.

Adult↗
PubMed1977

[Pentazocine--an addiction problem? (author's transl)].

Pentazocine dependencies are rare. In a period of 5 years, 60 were notified. The majority of these were not dependent. Of 46 utilizable notifications, 38 were false, 5 had taken pentazocine only temporarily or not at all. 19 received it for chronic or recurrent pains, 13 were polytoxicomaniacs, and 1 patient could not be classified. Only 8 cases could be referred to as pentazocine-dependent. The dose for addicts and polytoxicomaniacs was 11 ampoules daily on the average, almost three times as high as that for patients with painful diseases. Pentazocine dependencies are considerably less of a problem than those of opiates used up to now: withdrawal symptoms are slight, neglect and social dangers need scarely be considered. "Users" generally only turn to pentazocine when a painful disease supervenes. Dependency practically never occurs with oral administration.

Adolescent↗
PubMed1977

[An electroencephalographic comparison of fentanyl and sulfentanil (author's transl)].

Equipotent analgesic doses of sulfentanil and fentanyl showed similar effects in 281 cases of clinical neuroleptanalgesia. In rabbits equimolecular doses of sulfentanil induced a deeper narcotic effect (burst suppression) than fentanyl. This supports the thesis of a coincidental increase of analgesic potency and narcotic effect in agonistic opioids. In equipotent doses the conventional EEG and the amplitude-frequency-spectra are equal. Quantificated analyses and statistical calculations show essentially similar changes in animal: - Fentanyl as well as sulfentanil changes only the dominant frequency in the theta-bands. - The percentage value increases only in the sigma-band, doesn't change in the alpha- and beta1-band and decreases in the theta-band, beta2--and beta3-band. - The power of sigma rises by a potency of ten in both substances; the change in the other frequencies shows similar sizes. Fentanyl and sulfentanil do not coure differences in the EEG.

Adult↗
PubMed1976

[Electroencephalographic findings and occurence of seizures after surgery of the Gasserian ganglion].

The results of EEG investigations after Spiller-Frazier's operation for trigeminal neuralgia in 112 patients are reported. Follow-up EEGs were recorded within 1-8 years after surgery; two to three follow-up tracings were available in 53 patients. Two distinct phases of EEG alterations were noted: 1) The immediate postoperative phase characterized by bilateral delta waves of maximal distribution in the frontal-precentral area and in the temporal area on the side of surgery. Such alterations are supposedly due to postoperative edema or associated metabolic disturbances. 2) Several months after surgery focal abnormalities of the temporal lobe develop, which consist of high amplitude alpha-, beta- or theta-waves, sharp waves, spikes and occasional stypical spike-and-wave complexes. These abnormalities are reflected on the contralateral side in approximately one third of the case. Repeated EEGs confirmed the consistency of degree and location of these findings with the exception of a less constant incidence of spikes and sharp waves. Severity of EEG abnormalities and incidence of potentially epileptogenic discharges increases with age. In spite of the precarious location of such focal abnormalities in the temporal lobe only 3 of 112 patients (2.7%) reported seizures with temporal lobe features. The age of the three patients was below the average age of 59.1 years. Seizures occurred sporadically beginning approximately 2 years after surgery. The low incidence of seizures may in our opinion be due to the advanced age of most patients.

Adult↗