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Biomedical subjects

S Kruse-Andersen

Publications and source records attributed to S Kruse-Andersen.

29 records · Page 2Linked to original sources
PubMed1987

Effect of cisapride on the gastro-oesophageal function in normal human subjects.

The aim of this study was to investigate oesophageal peristalsis and gastro-oesophageal function in normal subjects after 4 days of cisapride 10 mg p.o. 3 times/day and 10 mg 1.5 h before the investigation. The study was carried out in a double-blind cross-over design with coded cisapride or placebo tablets. Basal sphincter pressure increased after cisapride (p less than 0.002). The peristaltic pressure amplitude in the oesophageal body as well as the duration and velocity of the peristaltic pressure wave were measured after wet swallows. No changes were found. Intragastric pH was unchanged after cisapride. No effect was found on the result of a standard acid clearing test. Plasma concentration of cisapride did not correlate with any of the other variables. Oral cisapride increases fasting gastro-oesophageal sphincter pressure, but does not influence oesophageal peristalsis, acid clearing or intragastric pH in normal subjects.

Adult↗
PubMed1986

Acid gastro-oesophageal reflux episodes as related to the quality of preceding peristalsis. A study in normal subjects.

It has earlier been demonstrated after long-term monitoring of pH and peristalsis in the oesophagus that episodes of acid gastro-oesophageal reflux occur in normal volunteers. To determine whether there is a connection between gastro-oesophageal reflux and prior peristalsis, pH and peristalsis were monitored for 12 h in 26 asymptomatic subjects. The recorded peristalsis was divided into brief bursts of peristaltic contractions (less than or equal to 60 sec) and more prolonged continuous activity. Peristaltic periods were limited to prior and subsequent peristalsis by a non-peristaltic course of greater than 30 sec. Continuous peristalsis was defined as a sequence of peristaltic contractions with a mutual distance between individual peristaltic waves of greater than or equal to 30 sec. A total of 81 episodes of reflux were recorded, of which 67 were preceded by peristaltic activity. Brief bursts of peristalsis, unrelated to reflux episodes, were frequently terminated by bolus-transporting peristaltic waves (p less than 0.001). When the last contraction before reflux was considered, an increased frequency of non-propagating peristalsis was found (p less than 0.01). In addition, a closer time relationship was observed between peristalsis and reflux if the last contraction was of the upper segmentary type, as compared with propagating activity (p less than 0.001). In conclusion, reflectory sphincter relaxation producing reflux may possibly be triggered by contractions in the upper part of the oseophagus, not followed by a bolus-transporting peristaltic wave.

Adult↗
PubMed1984

Diagnosis and repair of traumatic tracheal and tracheobronchial disruptions.

During the period from January 1968 to December 1982, 8 patients received emergency operations for traumatic tracheobronchial rupture in the Department of Thoracic Surgery, Odense University Hospital. Half of the lesions were the result of blunt trauma; the other half were penetrating injuries or iatrogenic lesions. All of them were treated within 24 hours by direct suture of the lesion. In our experience soft, rapidly absorbable sutures should be used in the cartilaginous and membraneous parts of the larynx and trachea, and tracheotomy should be avoided where at all possible. Using these principles we have been able to avoid completely any cases of re-stenosis with its attendant complications. After operation , most patients could respire normally, and they recovered well after a few hours or days of using an uncuffed nasotracheal tube.

Adult↗
PubMed1983

Regression of infundibular hypertrophy after pulmonary valvulotomy without myocardial resection.

In the period 1965-1979, 26 patients underwent valvulotomy for congenital pulmonary valve stenosis without ventricular septal defect. Infundibular stenosis was additionally present in 14 of the patients, 12 children and 2 adults, but myocardial resection in the infundibular area was not performed. During the first postoperative year the right ventricular outflow tract underwent normalization in the 12 children and the right ventricular systolic pressure normalized in all 14 patients. No relationship could be demonstrated between the R wave in the precordial lead V1 and the systolic pressure in the right ventricle, the gradient to the pulmonary artery or the extent of subvalvular hypertrophy.

Adult↗
PubMed1983

Arterial injuries of the upper extremities.

Twenty-five consecutive treated patients with traumatic lesions of upper extremity arteries are presented. All were males, and most were young and able-bodied. Simultaneous fracture and/or dislocation of bone was present in 17 of the 25 patients, nerve lesions in 14 and venous trauma in 7 patients. Serious injuries to other organs had occurred in 8 patients, 3 of whom had multi-trauma. Three patients died, 2 of them from injuries to other organs. Seven others underwent amputation of the limb. No amputation was necessitated by the arterial lesion only. The major causes of injury were traffic accidents (mostly involving motor-cycles) and industrial accidents. The rate of limb salvage in this patient series was 60%. All patients with traumatic arterial lesions should be seen as soon as possible by a vascular surgeon, even if there are serious injuries to other organs, so as to avoid unnecessary diagnostic procedures and optimize the prospects for arterial reconstruction.

Accidents, Traffic↗
PubMed1982

Intussusception of the mid-jejunum after small intestinal bypass operation for obesity: case report.

Invagination of the defunctionalized small intestine after jejunoileal bypass operation for morbid obesity is a serious but rare complication since the introduction of Wills' technique. The possibility, however, still exists of mechanical obstruction of other parts of the defunctionalized small intestine. This occurred in a 25-yr-old man on several occasions during an interval of 1 to 3 yr after the primary operation.

Adult↗