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Biomedical subjects

S Krugman

Publications and source records attributed to S Krugman.

At least 55 records · Page 3Linked to original sources
PubMed1981

Disappearance of hepatitis B surface antigen during an unusual case of fulminant hepatitis B.

A 30-year-old surgical resident was admitted to the hospital with symptoms of acute hepatitis; two days later he became comatose. Hepatitis B surface antigen had been detected in his serum two days prior to admission, but it was not detected at any time thereafter. Hepatitis B e antigen, antibody to hepatitis B core antigen, and antibody to hepatitis B surface antigen were detected using sensitive radioimmunoassays at admission. Titers of antibody to hepatitis B core antigen increased over the next five weeks. Clearance of hepatitis B e antigen and subsequent appearance of antibody to hepatitis B e antigen accompanied clinical improvement and recovery. This unusual case documents that hepatitis B surface antigen can become undetectable during the course of fulminant hepatitis B and indicates the importance of tests for other serologic markers of hepatitis B virus in the evaluation of hepatitis B surface antigen-negative fulminant hepatitis.

Adult↗
PubMed1981

Evidence of prior hepatitis B and hepatitis A virus infections in an ambulatory geriatric population.

Ninety-five randomly selected patients attending an ambulatory geriatric medical clinic were tested for the presence in their sera of hepatitis B surface antigen and of antibody to hepatitis B and A viruses. Such evidence of past hepatitis infection was correlated with current liver function and history of having received blood transfusions. The results showed that 94% of patients had antibody to hepatitis A virus, and 32% had antibody to hepatitis B virus. Patients with abnormal liver function tests, or those with a history of blood transfusions were no more likely to have hepatitis B antibody than patients with normal liver function tests or those with no history of transfusion.

Aged↗
PubMed1980

Measles again.

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Adolescent↗
PubMed1979

Viral hepatitis, type B. Studies on natural history and prevention re-examined.

Frozen serial serum specimens obtained from past studies on the natural history and prevention of Type B hepatitis in children were retested by radioimmunoassay for the following markers of hepatitis B infection: hepatitis B surface antigen (HBsAg) and antibody (anti-HBs), hepatitis B e antigen (HBeAg) and antibody (anti-HBe), and antibody to hepatitis B core antigen (anti-HBc). The interval between exposure and evidence of viremia (HBsAg) was as short as six days. HBsAg and HBeAg persisted for two to five months and occasionally for more than one year after recovery. After the disappearance of their respective antigens, anti-HBc and anti-HBs persisted for more than seven years and anti-HBe for one to two years. Treatment with hepatitis B immune globulin after exposure induced complete or partial protection or prolongation of the incubation period. Administration of heat-inactivated hepatitis B virus, MS-2 strain, to 29 children induced an inapparent infection in three, characterized by a transient appearance of HBsAg and HBeAg, and the persistence of anti-HBc, anti-HBe and anti-HBs for more than two years.

Aspartate Aminotransferases↗
PubMed1979

Sensitive neutralization test for rubella antibody.

A modified rubella virus plaque neutralization test for measuring rubella antibody was developed based on the potentiation of the virus-antibody complex by heterologous anti-immunoglobulin. The test is highly sensitive, yielding titers on the average 50 to 100 times higher than the haemagglutination inhibition test or the conventional plaque neutralization test. The sensitivity of this enhanced neutralization test is somewhat limited by the existence of a prozone phenomenon which precludes testing of low-titered sera below a dilution of 1:16. No prozone effect was observed with cerebrospinal fluids. The specificity of the enhanced neutralization test was determined by seroconversion of individuals receiving rubella vaccine. Although the rubella hemagglutination inhibition test remains the test of choice in routine diagnostic and surveillance work, the enhanced rubella neutralization test is particularly useful in monitoring low-level antibody in the cerebrospinal fluid in patients with neurological disorders and in certain instances of vaccine failure.

Adolescent↗
PubMed1979

Measles and mumps immunization: benefit versus risk factors.

Measles and mumps are universal diseases that affect more than 90% of the population of most countries of the world. During the prevaccine era about 98% of young adults had serologic evidence of past measles infection. Although mumps infection was less prevalent, about 90% of persons were infected before they reached their 20th birthday. Before vaccines were available, measles and mumps were inevitable infections of childhood. Therefore, an assessment of the benefits and risks of immunization to prevent these diseases must also consider the consequences of naturally acquired measles and mumps infections.

Adolescent↗
PubMed1978

Viral hepatitis.

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Animals↗