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Biomedical subjects

S Krishnamurthy

Publications and source records attributed to S Krishnamurthy.

172 records · Page 10Linked to original sources
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The Kveim test in leprosy.

The response to lepromin and Kveim antigens was compared and studied in 15 leprosy patients who were tuberculin negative. Of the 11 lepromin positive tuberculoid patients, 4 were Kveim positive, 1 was equivocal, and the rest were negative. Of the four lepromin negative lepromatous patients, one gave a positive Kveim test while the other three were negative. It has been shown that false-positive Kveim reactions are found in a higher percentage of South Indian leprosy patients than in those of other backgrounds, such as Japanese and Malaysian Chinese patients. It is also suggested that no definite relationship exists between the reaction of leprosy patients to lepromin and Kveim antigens. We further suggest that the anergy exhibited by lepromatous patients to the antigen of M. leprae is specific, as evidenced by the positive Kveim response in one lepromatous patient.

China↗
PubMedDate not supplied

Factors affecting in vitro lipid peroxidation of rat brain homogenate.

Peroxidation of the unsaturated lipid of tissue homogenates is an established method to assess the antioxidant or vitamin E status of animals. In the present study the spontaneous lipid peroxidation in air of rat brain homogenates is reported. The effects of various factors like pH, time, concentration of tissues, temperature, ferrocompounds and catalysis by added tissues like liver are described. Rat brain homogenates appear to be a suitable preparation for in vitro studies of lipid peroxidation.

Animals↗
PubMedDate not supplied

Potential years of life lost by major childhood cancer deaths in Bombay.

BACKGROUND: Over the last two decades mortality from childhood cancers has declined in the West, possibly due to advances in chemotherapy. Unfortunately, poor countries cannot afford these drugs as they are costly and scarce. We undertook this study in Bombay to help us make rational choices in this area. METHODS: We studied the mortality, incidence and years of potential life lost by premature death from specific cancers in children under 15 years of age. RESULTS: Leukaemia accounted for 30% to 50% of premature life lost by death from cancers regardless of gender or age, i.e. if such loss was avoided by timely diagnosis and therapy, up to 50% gain of person-life would occur. It constituted nearly one-third of the childhood cancers, with age-adjusted rates comparable with American blacks and whites in boys, but less in girls. Incidence and decline of mortality due to leukaemia from 1964 was lower in girls than in boys. CONCLUSIONS: A focus on leukaemia treatment would increase productive person-life by nearly 50%. A triaging system might be the best method for allocating treatment till data on cost of such therapy are available. There is a need to increase morphological diagnoses in girls. Concentrating on treating girls with leukaemia older than 5 might contribute most in terms of gain in human potential and would be a cost-effective use of scarce resources.

Adolescent↗
PubMedDate not supplied

Gastric carcinoids--a clinicopathologic study.

AIM: Our objective was to document the clinical and pathological findings in eight patients with gastric carcinoids seen in our institution over a 16-year period (1980-96). METHODS: All cases reported during this period as microcarcinoids, atypical carcinoids and mixed carcinoid-carcinoma of the stomach were retrieved from pathology records. Eight cases with typical histologic features of carcinoid were studied. RESULTS: Seven cases were men (median age 53 years, range 35-55). Four patients presented with upper abdominal pain. Serum gastrin level was elevated in two cases. The endoscopic appearances and the endoscopic biopsy histology were not diagnostic. Surgical treatment ranged from simple nodule excision to partial, subtotal or extended gastrectomy and Whipple's pancreatico-duodenectomy. Lymph node and liver metastasis were seen in four patients each. The median duration of follow-up was one year. CONCLUSION: Gastric carcinoids have varied etiopathogenesis. These may arise in a background of hypergastrinemic conditions or may be sporadic. Most appear to be slow growing but aggressive neoplasms are capable of distant metastasis.

Adult↗