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Biomedical subjects

S Komatsu

Publications and source records attributed to S Komatsu.

At least 361 records · Page 20Linked to original sources
PubMed1984

A successful procedure for correction of the Taussig-Bing malformation.

We report upon a successful procedure for surgical correction of the Taussig-Bing malformation. This procedure consisted of resection of the aortic conal septum and direction of left ventricular blood flow through the ventricular septal defect to the aorta by use of a nonvalved conduit (14 mm in diameter) in the right ventricle. The patient survived the operation and postoperative hemodynamics were excellent 10 months postoperatively.

Aorta, Thoracic↗
PubMed1983

Effect of coenzyme Q10 on hypertrophied ischemic myocardium during aortic cross clamping for 2 hr, from the aspect of energy metabolism.

In order to perform intracardiac repair safely during aortic cross clamping, we designed this study to evaluate the protective effect of coenzyme Q10 (CoQ10) on hypertrophied ischemic myocardium from the aspect of energy metabolism. Six to nine months preceding the study, aortic bandings were carried out on 14 puppies to produce left ventricular hypertrophy (LVH). These dogs with LVH were then subjected to total cardiopulmonary bypass and were evenly divided into control and CoQ10-treated groups (10 mg/kg of intravenous administration plus 1 mg/kg per hr of intracoronary injection). Myocardial ischemia was induced by aortic cross clamping for 2 hr under moderate systemic hypothermia. The results indicated that the administration of CoQ10 had a protective effect on hypertrophied ischemic myocardium, since depletion of high-energy phosphate (HEP) was uniformly prevented, and accumulation of lactate was simultaneously decreased during the 2 hr of aortic cross clamping. On the other hand, there were marked exhaustion of HEP and rapid increase in lactate following the 2 hr of ischemia in the control group, these being much more predominant in the subendocardial layer.

Adenosine Triphosphate↗
PubMed1983

New embolization method using estrogen: effect of estrogen on microcirculation.

To ascertain the mechanism of action of estrogen administered by a new embolization method, developed by the authors as a treatment method for dural arteriovenous malformations, conjugated estrogens were injected into the mesenteric artery of rabbits, and microcirculatory changes in the dominant areas were studied biomicroscopically. Conjugated estrogen induced sludging and stasis in the microcirculation, approximately in proportion to the concentration and dose.

Animals↗
PubMed1983

Conduction disturbances and operative results after closure of ventricular septal defects by three different surgical approaches.

A total of 135 patients with ventricular septal defect (VSD) under 15 years of age, without associated cardiac lesions, underwent surgical repair by 3 different approaches of trans-pulmonary arteriotomy (PA), right atriotomy (RA) and right ventriculotomy (RA) between 1977 and 1981. Six hospital deaths (4.4%) occurred among the 135 patients. Of 41 children with PA, 53 with RA and 41 with RV, one child (2.4%), one child (1.9%) and 4 children (9.9%) died, respectively. In the trans-PA approach, 8 of 40 children (20.0%) developed complete right bundle branch block (CRBBB), but there was no occurrence of left axis deviation (LAD), transient complete heart block (CHB) and arrhythmias postoperatively. In the RA approach, 11 of 52 children (21.2%) developed CRBBB and 2 (3.8%) had a combination of LAD and CRBBB. Four of 52 children (7.7%) had a combination of LAD, CRBBB and CHB, but CHB has been treated successfully with medication. Three patients (5.8%) developed arrhythmias, such as junctional rhythm. In the trans-RV approach, 11 of 37 children (29.7%) developed CRBBB and 4 of the 37 (10.8%) had the combination of LAD and CRBBB. Two patients (5.4%) had arrhythmias which disappeared one month after surgery. All incidences of conduction disturbances and arrhythmias after closure of VSD were significantly less in the trans-PA than in the trans-RA or in the trans-RV (p less than 0.01). However, in the present study, the development of conduction disturbances and postoperative arrhythmias after closure of VSD was not significantly different between the trans-RA and the trans-RV approach.

Adolescent↗
PubMed1983

Valve replacement for Ebstein's anomaly of the tricuspid valve. Early and long-term results of eight cases.

The role of valve replacement in the treatment of Ebstein's anomaly of the tricuspid valve remains controversial. Since 1965, eight patients with Ebstein's anomaly ranging in age from seven to 22 years of age (mean 13 years) have undergone tricuspid valve replacement (TVR) in our institution. Seven were in functional class 3 or 4 (NYHA), while one was in class 2, but had an increase in cardiac size. All of these eight patients showed moderate to severe cardiomegaly (cardiothoracic ratio: 54-75 percent). The valve was placed on the tricuspid annulus in seven of the eight cases, the exception being one case in which it was placed above the coronary sinus. Seven artificial prostheses (two Starr-Edwards, one Harken, one Kay-Shilley and three Wada-Cutter) and one porcine valve (Hancock) were used. There was one operative death in an early case due to postoperative complete heart block. Follow-up (range three to 18 years) of the other seven survival patients showed three late deaths; the first a pulmonary embolus 2.6 years after TVR; the second with congestive heart failure two years following the operation; and the third with arrhythmias five years after TVR. The remaining four patients are now in functional class 1 (three cases) and class 2 (one case). Valve replacement for Ebstein's anomaly can produce good clinical improvement and provide excellent long-term results.

Adolescent↗