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Biomedical subjects

S Komatsu

Publications and source records attributed to S Komatsu.

At least 289 records · Page 16Linked to original sources
PubMed1987

[A case of aneurysmal dilatation of a saphenous vein graft for subclavian aneurysm in a patient with Behçet disease].

The autogenous saphenous vein is the preferred conduit for repair of occluded arteries in the limb and coronary arteries. The aneurysmal dilatation of the vein graft is a unusual complication in the long-term period. A case of aneurysmal formation of the vein graft for the subclavian aneurysm 5 years after grafting with classic Behçet disease was reported. The etiology of this rare complication and the special surgical problem were also discussed.

Adult↗
PubMed1986

Cooperative inhibitory effect of follicular fluid and cAMP on hamster oocyte maturation.

Porcine or human follicular fluid inhibited the spontaneous maturation of isolated hamster oocytes in vitro during the first 1.5 h of culture. Moreover, the presence of 50% follicular fluid combined with 100 microM dbcAMP cooperatively reduced the incidence of germinal vesicle breakdown. The addition of FSH also inhibited the resumption of meiosis, and the presence of LH did not overcome the inhibitory effects of follicular fluid and tended to impede isolated hamster oocyte maturation in vitro.

Animals↗
PubMed1986

Surgical repair of a submitral annular aneurysm in a child.

A 5-year-old Japanese boy was admitted to the hospital with a submitral annular aneurysm of unknown etiology. Aneurysmectomy and repair of this defect with a Gore-Tex patch were performed. A review of English-language literature indicates that this is the first reported case of a submitral annular aneurysm in an Oriental child.

Child, Preschool↗
PubMed1986

Successful repair of double-outlet right ventricle by a modified Fontan operation.

Patients having a double-outlet right ventricle with an unfavorable anatomy for reparative conduit procedure present a formidable surgical challenge. Three such patients, aged 10, 13, and 14 years, with double-outlet right ventricle associated with atrioventricular discordance in 2 and atrioventricular concordance in 1, levotransposition of the great vessels and dextrocardia. A large-diameter direct anastomosis of the right atrium to the pulmonary artery was performed after the closure of the atrioventricular and pulmonary valves. All patients were operated on successfully with good clinical and hemodynamic results. Postoperatively, all 3 were acyanotic and had an improved physical activity compared with their preoperative status. Mean cardiac index at rest was 3.23 L/min/m2 and was increased to 5.04 L/min/m2 during exercise. These results indicate that this procedure can be of value for patients with double-outlet right ventricle in whom reparative surgery is technically difficult or infeasible.

Adolescent↗
PubMed1986

Long-term management of patients with cardiac valve prostheses.

Marked improvements have been achieved in the results of valve replacement due to recent developments in cardiac valve prostheses, surgical procedures, myocardial protection methods, and supportive techniques. Since 1974, the aortic valve has been replaced with mechanical valves and the mitral valve with biological valves at our institution. During a cumulative follow-up of 1024 patient-years after 306 valve replacements (126 AVR, 148 MVR and 32 AVR + MVR), the 10-year survival rates were 88% for AVR, 72.6% for MVR and 77.5% for AVR + MVR. The cardiac function of 90% of the survivors was evaluated as Class I or II according to NYHA Functional Classification. As for valve-related postoperative complications, thromboembolism was observed in 2.3%/pt-yr, hemorrhage in 0.5%/pt-yr, prosthetic valve endocarditis in 1.3%/pt-yr, perivalvular regurgitation in 1.3%/pt-yr and valve malfunction in 1.1%/pt-yr. Of the causes of late deaths, 62.5% were related to valve complications. Re-replacement of the prosthesis was necessary in 17 patients due to valve-related complications, and early death occurred in 1 (5.9%) of these 17. While cardiac valve replacement contributes to improvements in the quality of the patients' long-term postoperative life, currently employed artificial valves are still not ideal with regard to their materials and design, and re-replacement may become necessary in the late postoperative period. Therefore, in addition to selection of the appropriate valve prosthesis for different disorders and optimal prevention of valve-related complications, early diagnosis by non-invasive techniques and early treatment of these complications if they have occurred are of particular importance for the long-term management of patients following cardiac valve replacement.

Activities of Daily Living↗
PubMed1986

Functional recovery of locomotive behavior in the adult spinal dog.

Complete transection of the midthoracic spinal cord was performed on adult female dogs. Development of reflexes and locomotive movements in the hindlimbs after spinal transection was investigated over several months. In the earlier stages after the surgery, dogs showed flaccid paralysis of the hindlimbs. Within several weeks, muscle tone of the hindlimbs was gradually increased accompanied by development of flexion reflex with after-discharge in addition to monosynaptic reflexes. Alternating stepping movement also began to develop. Afterward, extensor thrust and crossed extension reflex were observed. Standing behavior of the hindlimbs was found after enough development of the extensor thrust and correct placement of the pads of the toes. Steady development of stepping and standing caused forward locomotion using fore- and hindlimbs. This walking behavior of the hindlimbs was never inhibited by additional spinal cord transection. These findings indicate that the isolated spinal cord caudal to the transected site is responsible for the locomotive behavior of the hindlimbs in adult spinal dogs. Spinal automatism and development of responses induced by afferent inflow from outside the cord may help to explain such functional recovery of the paralyzed hindlimbs.

Animals↗
PubMed1986

In vitro fertilization and development of ova obtained from female mice treated with aminopterin and mitomycin C.

We examined the effects of mitomycin C and aminopterin on ovulation in vivo and, fertilization, subsequent cleavage and implantation in slc-ICR female mice using methods of fertilization and culture in vitro. Chemicals were injected into mice at the MI (meiosis I) stage or 3 hours before the MI stage in order to examine their toxicity. Mitomycin C did not affect ovulation, but decreased the rate of fertilization. A high dose of mitomycin C (4 mg/kg) inhibited fertilization and the development of ova to the 2-cell stage. Aminopterin affected neither ovulation nor fertilization. At either the MII (meiosis II) stage or 3 hours before the MII stage, high doses (4 and 2 mg/kg) of mitomycin C arrested cleavage and implantation. The cleavage was blocked frequently between the 3-4 cell stage and the 5-8 cell stage. Aminopterin affected neither cleavage nor implantation.

Aminopterin↗