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Biomedical subjects

S Kohno

Publications and source records attributed to S Kohno.

At least 793 records · Page 44Linked to original sources
PubMed1976

Reversible inhibition of interferon-induced antiviral state by deoxyadenosine.

Deoxyadenosine reversibly inhibited the development of antiviral state (AVS) in chick embryo fibroblasts stimulated by interferon. Studies on cellular macromolecular syntheses in deoxyadenosine-treated cells suggested that the inhibition was related to nucleolar RNA synthesis. Reference experiments with actinomycin D and cordycepin (3'deoxyadenosine) also implied causal- or interrelation between AVS development and nucleolar RNA synthesis.

Adenine↗
PubMed1975

Binding of polyriboinosinic-polyribocytidylic acid with cultured cells.

Homogenates prepared from polyriboinosinic-polyribocytidylic acid copolymer [poly(rI) - poly(rC)]-treated cells exhibited antiviral activity in chick embryo, L and rabbit kidney cells. The antiviral activity in the homogenate co-sedimented with cellular membrane material and was shown to be poly(rI) - poly(rC) by a hybridization competition test with immobilized polyribocytidylic acid. The results indicate that poly(rI) - poly(rC) binds firmly to cellular membrane. These studies, however, could not differentiate between specific binding leading to the interferon induction and non-specific binding possibly unrelated to the induction of interferon.

Animals↗
PubMedDate not supplied

Bilio-enteric anastomosis as a risk factor for postembolic hepatic abscesses.

In 2 patients who had undergone pancreatoduodenectomy with choledochojejunostomy, a subsequently detected metastatic tumor of the liver was treated with transcatheter arterial embolization. Weeks later intrahepatic abscesses developed. Pathophysiologic processes that may lead to this complication of hepatic embolization are discussed.

Adult↗
PubMedDate not supplied

Osseous metastases from hepatocellular carcinoma: embolization for pain control.

Transcatheter arterial embolization for osseous metastasis of hepatocellular carcinoma (HCC) was performed in 7 patients. The embolization therapy was used in patients in whom the feeding artery could be catheterized. All tumors were accompanied by abundant neovascularity and tumor stain. Embolization was successfully performed in 5 patients, all of whom became symptom free within a week. The only complication was local pain which was controlled by nonnarcotic pain medication. Embolization may be a useful treatment method for osseous metastasis of HCC.

Aged↗
PubMedDate not supplied

CT manifestations of a ruptured hepatic tumor after transcatheter arterial embolization.

There are few reports of the radiologic diagnosis of ruptured hepatic tumors. In a patient with right upper abdominal pain and impending shock, angiography demonstrated a hypervascular hepatic tumor, and CT imaged an extrahepatic mass suggestive of a hematoma. Following transcatheter arterial embolization with Lipiodol Ultrafluide and gelatin-sponge, multiple contiguous CT sections revealed numerous lipiodol droplets adjacent to a lipiodol-containing hepatic tumor, clearly outside the liver. These findings were indicative of a ruptured hepatic tumor. After embolization, the patient's condition improved and he was discharged.

Carcinoma, Hepatocellular↗