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Biomedical subjects

S Koda

Publications and source records attributed to S Koda.

68 records · Page 4Linked to original sources
PubMed1986

Serum lactate dehydrogenase and its isozymes in lupus nephritis.

The relationship between the renal pathologic activity of systemic lupus erythematosus (SLE) and serum lactate dehydrogenase (LDH) was examined in 28 patients with active SLE involving only the kidney. Serum levels of total LDH, LDH1, and LDH2 were significantly higher in the patients with diffuse proliferative lupus nephritis (World Health Organization class IV) than in those with milder renal disease (classes I through III and V). Total LDH levels showed good correlations with the activity index and the total pathologic score of the renal pathologic scoring system, and with the glomerular hypercellularity and overall deposits. The elevated level of LDH was mainly due to elevated levels of its isozymes LDH1 and LDH2. These results suggest that the elevation of serum LDH levels in patients with SLE reflects the renal pathologic changes due to lupus nephritis.

Adolescent↗
PubMed1985

Studies on the interaction between alkali metal cations and polyion by sound velocity.

The sound velocities in polyelectrolyte solutions were measured at various concentrations of added salts. When aqueous solutions of tetra (n-butyl)ammonium polyacrylate were titrated with concentrated solutions of LiCl, NaCl, KCl or CsCl, the sound velocity, i.e., the adiabatic compressibility of the solution, did not change linearly with added salt concentration, but showed a breaking point. The degrees of counterion binding on polyacrylate ion estimated from the breaking points were 0.25-0.30, independent of cation species. In polystyrenesulfonate, moreover, no Na+ binding was detected from such sound velocity measurements.

Journal Article↗
PubMed1983

Raman spectroscopic studies on the interaction between divalent counterion and polyion.

The nature of the interaction between polyacrylate ion and several divalent cations, such as Cu2+, Mn2+, Zn2+, Ba2+ and Mg2+, was investigated using Raman spectroscopy. A specific Raman band characteristic of a carboxyl group is shifted upon addition of Cu2+, Zn2+ and Mn2+ to partially neutralized poly(acrylic acid). On the other hand, no frequency shift of the specific Raman band is observed on addition of Mg2+ and Ba2+, though the intensity of the specific Raman band decreases with concentration of MgCl2. It is concluded from these Raman data that the interaction between polyacrylate ion and Cu2+, Zn2+ or Mn2+ includes a specific interaction with bond formation, whereas in the case of Mg2+ and Ba2+, the electrostatic interaction is dominant.

Acrylic Resins↗
PubMed1983

[Postoperative chemotherapy of perforating appendicitis in children; with special reference to latamoxef therapy].

We employed latamoxef (LMOX) as antibiotic therapy subsequent to the performance of appendectomies in children. Fifteen patients, consisting of 8 cases of catarrhal appendicitis and 7 cases of gangrenous appendicitis, were administered LMOX at 50 mg/kg/day, while 13 patients with peritonitis due to a perforated appendix were treated with a dosage of 90 mg/kg/day. Both of these dosages were administered in 3 equally-divided doses, as one shot intravenous injections. All of the cases of catarrhal and gangrenous appendicitis showed good, steady recovery after the surgery, and there were no instances of complications. With regard to the 13 cases of perforating appendicitis, a clinical efficacy of at least "good" was obtained in 12 patients, for an efficacy rate of 92.3%. In addition, bacteriologically, 35 out of 36 strains that were isolated initially could no longer be detected after the LMOX therapy, indicating an eradication rate of 97.2%. Complications consisted of 1 case of dehiscence of the wound, and 1 case of adhesive ileus. Comparison of the values of the laboratory tests before and after the LMOX therapy revealed no development of abnormalities. Moreover, with regard to side effects, with the exception of 1 case of transient diarrhea, there were no side effects which presented clinical problems. It was found that the causative microbes involved in these cases of appendicitis--especially in the perforative appendicitis cases--were Gram-negative bacilli such as E. coli, and an anaerobic bacterium, B. fragilis.(ABSTRACT TRUNCATED AT 250 WORDS)

Anti-Bacterial Agents↗
PubMed1982

Raman spectroscopic studies on the interaction between counterion and polyion.

The interaction between alkali metal ions and the polyacrylate ion was investigated by means of Raman spectroscopy. in comparison with the Raman spectra of propionate salts. The Raman bands due to the metal-oxygen bond were not apparent and no significant difference was observed among the Raman spectra of several univalent salts of polyacrylate. except in the case of the lithium salt. The apparent degree of dissociation of lithium polyacrylate, as determined from the relative intensity of a specific band characteristic of the carboxylate ion, was lower than those of the other alkali metal salts. It is concluded from the Raman data that the electrostatic interaction between counterions and a polyion is not specifically modified by forces of a nonionic nature. Moreover, it is pointed out that the local conformation of polyacrylate changes gradually with the degree of neutralization, but that the change is not like a conformational transition between globular and random coil forms.

Journal Article↗
PubMedDate not supplied

Passive sampling and head space analysis for quantitative determination of nitrous oxide exposure.

A new technique has been developed for determining the time-weighted average personal exposure to nitrous oxide gas. Nitrous oxide gas is passively collected on a molecular sieve contained in a glass tube and partially desorbed in a vial until solid-gas equilibrium at 100 degrees C. Next, nitrous oxide concentration in the head space air in the vial is measured with a gas chromatograph equipped with an electron capture detector. This study shows that nitrous oxide concentration in the head space is proportional to both the nitrous oxide concentration in the test atmosphere and the sampling time up to 1600 ppm/hr. The coefficient of variance is less than 10%. The performance of the sampler is not affected by water vapor or carbon dioxide in the atmosphere nor by air currents. The sampler can be stored for 2 weeks at either 4 or 25 degrees C. Because the passive sampler is small and light, it can be used to determine exposure to nitrous oxide during surgical operations.

Air Pollution, Indoor↗