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Biomedical subjects

S Kitamura

Publications and source records attributed to S Kitamura.

At least 1,225 records · Page 68Linked to original sources
PubMed1975

Heavy metals in normal Japanese tissues. Amounts of 15 heavy metals in 30 subjects.

To obtain the usual values of arsenic, beryllium, bismuth, cadmium, chromium, cobalt, copper, mercury, methyl mercury, manganese, molybdenum, nickel, lead, antimony, vanadium, and zinc in the normal human body, the amounts of 15 metals were determined in 15 male and 15 female Japanese cadavers (average weight, 55 kg [121 lb]). The content of metals found ranged as follows: Zn, 1,800 mg; Cu, 65 mg; Cd, 35 mg; Pb, 25 mg; Mn, 8 mg; Ni, 6 mg; Cr, 4 mg; Hg, 3 mg; Sb, 0.7 mg; MeHg, 0.4 mg. Cadmium and mercury were higher in Japanese blood than in blood of other people. Cadmium and mercury were absorbed by the metabolic tissues; Cr, Ni, and Pb showed higher concentration in tissue exposed to the environment. Concentrations of Cd, Pb, and Hg tended to be higher in females, and Cr Cu, MeHg, and Mn concentrations tended to be higher in males.

Adolescent↗
PubMed1975

Experimental rheumatoid arthritis-like features induced by prolonged sensitization with focal antigens.

Prolonged sensitization with emulsion of an autologous or isologous subcutaneous abscess of Arthus type induced by injection of hen egg-white was performed in 34 rabbits which were divided into (high responder and intermediate responder groups (H- and M-groups) according to individual difference of immune responses. The development of a rheumatoid factor-like substance (RFLS) was demonstrated after 30 experimental days and subsequently observed in 21 out of 33 rabbits. There was no significant difference in the incidence of RFLS between both groups. As to the relation between the development of RFLS and types of focal antigens, the group of the autologous W-substance showed a higher incidence of RFLS than the N-substance. Acute and/or chronic synovitis was demonstrated in 13 of 33 rabbits and inflammatory changes were more intensive and extensive in the later period of experiment. Presence of RFLS in the affected synovial tissues, chiefly in the cytoplasm of plasma cells and mononuclear cells, occasionally in a free state was revealed by immunofluorescent study, and depositions positive for IgG and beta 1C were observed in the wall of blood vessels and fibrinous thrombi in the affected synovial tissues.

Animals↗
PubMed1975

Transfemoral plug closure of patent ductus arteriosus. Experiences in 61 consecutive cases treated without thoracotomy.

We successfully closed the isolated patent ductus arteriosus in 58 of 61 consecutive patients using the transfemoral-catheter method originally introduced by Porstmann in 1968. To perform this technique more safely and reliably, some instrumental and technical improvements were made. The indications for this method have been expanded to include the cylindrical or window-type ductus as well as the conical-shaped ductus. Classification into three groups of the configuration of the ductus by angiography has been useful in selecting the shape of the closing plug. Whenever feasible, we consider the catheter technique to be the method of choice to close the ductus.

Adolescent↗
PubMed1975

The metabolism of phenyl o-(2-N-morpholinoethoxy)-phenyl ether hydrochloride in the rabbit and rat.

1. Urinary and faecal excretion of radioactivity in 120 h after oral administration of [U-14-C]phenyl o-(2-N-morpholinoethoxy)phenyl ether hydrochloride (200 mg/kg) were 92 and 3% dose in the rabbit, and 60 and 35% in the rat. 2. Urinary metabolites were produced by aromatic hydroxylation and aryl alkyl ether bond cleavage. Some evidence for formation of dioxomorpholino, oxohydroxymorpholino, and ethanolamino derivatives of the drug was obtained. 3. The aromatic hydroxylation product, p-hydroxyphenyl o-(2-N-morpholinoethoxy)phenyl ether hydrochloride had vasopressor activity comparable with the parent compound, but with shorter duration of action.

Animals↗
PubMed1975

Vasoactive intestinal polypoptide: inactivation in liver and potentiation in lung of anesthetized dogs (384699).

The role of the liver and the lung in the inactivation or potentiation of the biological activity of the vasoactive intestinal polypeptide (VIP) was examined in five anesthetized dogs. Infusions of the peptide were made into the right ventricle, the left ventricle, and the portal vein. Each animal received 4 doses, ranging from 0.29 to 2.23 mug/kg. Systemic arterial blood pressure, tidal volume, breathing frequency, and minute ventilation were continually monitored. The biological effects of the peptide were measured in terms of (a) the fall in arterial blood pressure; and (b) respiratory stimulation. Infusions of the peptide into the portal vein produced either no effect or significantly weaker effects (p smaller than 0.01) than infusions into the right ventricle. The latter infusions were moderately more potent (p smaller than 0.05) than infusions into the left ventricle VIP thus appears to be effectively inactivated during passage through the liver. The apparent increase in biological potency of the peptide during its passage through the lung may be attributable to the release of additional vasodilator substances, or to further activation of the peptide.

Animals↗
PubMed1975

Multiple coronary artery aneurysms resulting in myocardial infarction in a young man: treatment by double aorta-coronary saphenous vein bypass grafting.

A 26-year-old Japanese man was treated for a transmural myocardial infarct caused by multiple aneurysms of the left main (LMC), left anterior descending (LAD), and the right coronary arteries (RCA). He underwent successful double aorta-coronary saphenous vein bypass grafting. The etiology of the aneurysm remains uncertain but an inflammatory origin is most probable. Review of the literature has indicated that this is the seventh case of coronary artery aneurysms without arteriovenous fistulas to be managed by grafting techniques with the saphenous vein. This experience has suggested that young patients presenting with anginal pain or myocardial infarction whould be carefully examined for coronary artery aneurysms. Since most of the patients developed myocardial infarction probably from thrombotic occlusion or embolism of the distal vessel, this lesion should be considered for surgery whenever anatomically feasible. Coronary artery reconstruction by grafting techniques, with or without resection of the aneurysm, is the treatment of choice. Although surgical treatment has provided good clinical amelioration to our patient as well as the patients previoulsy reported, a careful long-term follow-up should be continued for patients with multiple coronary artery aneurysms of doubtful origin.

Adult↗