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Biomedical subjects

S Kishimoto

Publications and source records attributed to S Kishimoto.

551 records · Page 31Linked to original sources
PubMedDate not supplied

Temporal bone findings in a patient with Möbius syndrome.

Temporal bone findings in a case of Möbius syndrome are presented. The most striking pathological feature of the case is that the facial nerves ended in the horizontal segment in the temporal bones on both sides. This finding gives direct evidence that the site of nerve lesion in Möbius syndrome is in the peripheral nerve. Despite the disappearance of facial nerve in the horizontal segment, a neural element reappeared in the vertical segment of the fallopian canal, and moreover, the chorda tympani was found to cross the tympanic cavity in the normal position. This finding suggests that fibers of the chorda tympani sometimes take an alternative pathway via Arnold's nerve.

Aged↗
PubMedDate not supplied

Successful pregnancy and delivery in a patient with neurogenic orthostatic hypotension and achalasia: a case report.

A successful pregnancy and delivery in a patient with neurogenic orthostatic hypotension and a past medical history of achalasia is described. Surprisingly, she was free from orthostatic hypotension during the last trimester, though the evaluation of adrenergic function by measurements of changes in plasma norepinephrine on standing and by the response of blood pressure to infused norepinephrine revealed no difference between function before pregnancy and that during the last trimester. Orthostatic hypotension started again just after delivery.

Adult↗
PubMedDate not supplied

Intraosseous hemangioma of the vomer: a case report.

We describe an unusual case of intraosseous hemangioma of the vomer. The lesion had a characteristic radiographic appearance, especially on the computed tomographic scan. The two most interesting points in this case were the rarity as a site for the occurrence of hemangioma and the successful extirpation of the tumor via the Le Fort 1 osteotomy approach without embolization of the feeding vessels. The benefits of this approach included the wide surgical field afforded deep in the midface region, which was important for controlling bleeding, as well as the complete extirpation of the tumor.

Blood Loss, Surgical↗
PubMedDate not supplied

Cutaneous infiltration by leukemic cells in acute promyelocytic leukemia of a child after treatment with all-trans retinoic acid.

We describe here the first case of childhood acute promyelocytic leukemia (APL) with cutaneous infiltration of leukemic cells following treatment with all-trans retinoic acid (ATRA) confirmed by immunostaining and polymerase chain reaction for PML/RAR alpha. An 11-year-old girl was diagnosed as having APL. Chromosomal analysis demonstrated the characteristic karyotype of t(15;17). ATRA therapy was begun at a dose of 45 mg/m2 daily. During ATRA therapy, leukocytosis and retinoic acid syndrome were observed but were resolved by dexamethasone. Two months after commencement of ATRA therapy, complete remission was achieved. During the course of consolidation chemotherapy, however, multiple cutaneous nodules developed in her trunk, the size and number of which increased despite intensive chemotherapy. Histological and immunological studies of the cutaneous nodules showed infiltration of leukemic cells. PML/RAR alpha mRNA was detected in both the cutaneous nodules and bone marrow by means of polymerase chain reaction. ATRA treatment for APL may be associated with an increased incidence of extramedullary disease such as cutaneous lesions. The best available therapy for APL may be a combination of ATRA and chemotherapy, especially when a marked leukocytosis occurs during ATRA therapy.

Antineoplastic Agents↗
PubMedDate not supplied

Changes of mutant-type p53 expression in squamous cell carcinoma of the head and neck during radiation therapy and its clinical significance: comparison of an immunohistochemical method and PCR-SSCP assay.

P53 has been reported to be one of tumor suppressor genes that play a major role in signal transduction following many kinds of stresses, including ionizing radiation. Changes in p53 expression during radiation therapy in tumor tissues have not yet been reported. We determined whether radiotherapy changes p53 expression in human squamous cell carcinomas of the head and neck, and established the possible correlations between p53 expression and the therapeutic effects of radiation therapy. 30 patients with tumors of the oral cavity, oropharynx, and maxillary sinus were examined, and all the tumors were confirmed as squamous cell carcinomas. Biopsies were performed on the cancer tissues before treatment and at doses of 4, 10, and 20 Gy of radiotherapy, and the specimens were preserved in liquid nitrogen for further examination. Samples were immunohistochemically stained using streptoavidin-biotin peroxidase method and a monoclonal antibody against p53 (Ab-3, mutant type). For all the samples p53 PCR-SSCP (polymerase chain reaction-single strand conformation polymorphism) assays were performed. 14 of the 30 patients with squamous cell carcinomas showed expression of p53 in their tumor cells before and/or at 4 Gy or 10 Gy of radiotherapy. Eleven of the 14 tumors showed high radiosensitivity. Results of the p53 PCR-SSCP assays revealed mutations of p53 in 13 of 30 patients examined, and percentages of mutated p53 DNA varied at radiation doses of 4 Gy and 10 Gy. Ten of 12 patients with mutated p53 in their tumors showed decreased percentages of mutated p53 DNA during radiotherapy. The relationship between the immunohistochemical findings and the antitumor effect of a radiation dose of 20 Gy was examined on the correspondent hematoxylin-eosin sections. In patients whose p53 expressions in tumor cells were grades + or ++ or before radiotherapy and/or at 4 Gy of radiotherapy, the tumors responded significantly well to radiation therapy but the patients responded with significantly unfavorable clinical courses. The high radiosensitivity of squamous cell carcinomas in our samples could be explained by an overexpression of mutant type p53 in the tumor cells, and these mutant type p53-positive tumor cells possibly showed radioresponsiveness.

Adult↗
PubMedDate not supplied

Regulatory role of arachidonic acid-derived metabolites for proliferation of transformed murine Leydig cell in serum-free culture condition.

The growth-regulatory ability of eicosanoids from arachidonic acid is poorly understood. To investigate their role in cell growth, we cultured transformed murine Leydig cells (B-1 or B-1 F) in serum-free medium supplemented with various compounds modulating arachidonic acid metabolism. The addition of 5-lipoxygenase inhibitors (AA 861, NDGA and quercetin) showed a growth-stimulative effect. On the other hand, their growth was remarkably inhibited by arachidonic acid added into the culture medium. This growth-inhibiting ability of arachidonic acid was almost completely reversed by a simultaneous exposure of B-1 cells to lipoxygenase inhibitor. Exogenously added 5-HETE inhibited cell proliferation in a dose-dependent manner. These results suggest that 5-lipoxygenase-catalyzed products from arachidonic acid have the ability to suppress the proliferation of some transformed cells.

Acetophenones↗
PubMedDate not supplied

Effects of estrogen and tamoxifen on secretory glycoprotein synthesis in mouse Leydig cell tumor in vivo.

Effects of estrogen and tamoxifen on the synthesis of secretory proteins were examined using estrogen-responsive mouse Leydig tumor. Estrogenization of host mice bearing the tumor (T 124958-R) resulted in the appearance of the secretory glycoprotein with a molecular weight of 34,000 which was detected by incubation of dispersed cells or minced tissues with [35S]methionine. The discontinuation of in vivo estrogenization decreased the growth rate of the tumor with the simultaneous disappearance of this secretory protein. Transplantation of tumor grown in non-estrogenized mice showed reacquisition of estrogen dependency in terms of tumor growth as well as secretory glycoprotein synthesis. Furthermore, tamoxifen administration to mice enhanced the tumor growth with simultaneous induction of this secretory protein. These results suggest that this secretory glycoprotein can be used as a marker for estrogen- or tamoxifen-dependent growth in vivo.

Animals↗
PubMedDate not supplied

Phase I study with cell wall skeleton of Nocardia rubra.

Toxicity of the cell wall skeleton of Nocardia rubra (N-CWS) was evaluated in 60 patients with lung cancer, leukemia, and malignant melanoma who were given the agent intratumorally, intrapleurally, and intradermally in doses of 100-2000 micrograms. Fever was the most common toxic effect and was more frequent after intratumoral and intrapleural doses than after intradermal doses. The other predominant reaction was skin lesions such as erythema, induration, and abscess at the injection sites.

Abscess↗