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S King

Publications and source records attributed to S King.

At least 145 records · Page 8Linked to original sources
PubMed1994

Psychiatrists' ratings of expressed emotion.

The purpose of this study was to determine the extent to which psychiatrists are familiar with the concept of expressed emotion and to determine the extent of its use in their day-to-day practices. We also wished to test the ability of psychiatrists to estimate the expressed emotion status of the relatives of their patients. Following the assessment of expressed emotion in 96 relatives using the Camberwell Family Interview, the psychiatrists treating the schizophrenic patients were surveyed about their knowledge of expressed emotion and were asked to estimate the expressed emotion of their relatives. Thirty-five percent of the respondents use the expressed emotion concept daily in their practice. When the Camberwell Family Interview ratings of expressed emotion were compared with those from the psychiatrists, the agreement rate was no better than chance (45.7%). Without formal training in the use of the Camberwell Family Interview, practitioners are cautioned against ascribing an expressed emotion status to the relatives of their patients.

Adult↗
PubMed1994

Self-reported depressive symptoms in inner-city adolescents seeking routine health care.

This study examines the self-reported depressive symptoms of inner-city adolescents coming to a health center for routine care. Data were obtained from a confidential screening questionnaire. Of the 966 adolescents responding to questions about depression, 371 (38%) indicated never being down or depressed. Five hundred and seventy three indicated the frequency of their being down or depressed as follows: 446 (78%) infrequent (once a month or less) and 127 (22%) frequent (weekly or more often). Relationships between frequently feeling down or depressed and eight somatic and twelve psychosocial concerns were explored. A relative risk for frequently feeling down or depressed greater than threefold was found for six of these concerns, all psychosocial in nature. These data suggest that one-fifth of the teens coming for routine health care also reported frequent feelings of being down or depressed when specifically asked about such feelings. Identification of such teens may be facilitated by inquiries into specific somatic and psychosocial concerns. Follow-up care is also reviewed. Since adolescents do not routinely seek help for mental health concerns, health providers seeing adolescents for general health care should actively solicit information relating to such concerns.

Adolescent↗
PubMed1993

Heparin-steroid conjugates: new angiogenesis inhibitors with antitumor activity in mice.

Inhibitors of angiogenesis hold potential in the treatment of cancer and other diseases where the disease is caused or maintained by the inappropriate growth of blood vessels. In the present study, a novel inhibitor of angiogenesis was synthesized by covalently linking a nonanticoagulating derivative of heparin, heparin adipic hydrazide (HAH), by an acid-labile bond to the antiangiogenic steroid, cortisol. The rationale was that the heparin derivative, which binds to sulfated polyanion receptors on endothelial cells, should concentrate the steroid on the surface of vascular endothelial cells. Endocytosis of the conjugate and decomposition of the acid-labile linkage inside lysosomes and other acidic intracellular compartments should then lead to release of the cortisol and expression of its antiproliferative activity. Analysis of the stability of HAH-cortisol showed that it was stable at pH 7.4 and broke down rapidly (t1/2 15 min) at pH 4.8 at 37 degrees C. Treatment of murine pulmonary capillary endothelial cells with HAH-cortisol at 10(-5) M (with respect to cortisol) suppressed their DNA synthesis by 50% and inhibited their migration into wounded areas of confluent monolayers. HAH-cortisol at 10(-4) M (with respect to cortisol) did not suppress the DNA synthesis of Lewis lung carcinoma cells. Daily i.p. injections of HAH-cortisol into mice bearing s.c. sponge implants retarded vascularization of the sponge, and injections directly into the sponge abolished vascularization for as long as the injections were continued. Daily i.v. injections of HAH-cortisol at doses causing no apparent toxicity retarded the growth of solid s.c. Lewis lung carcinomas in mice by up to 65%. In all of these assays, equivalent treatments with a mixture of the HAH plus cortisol was significantly less effective. The antiproliferative effect of HAH-cortisol on endothelial cells appeared independent of the glucocorticoid activity of the steroid since HAH conjugated to 5 beta-pregnane-3 alpha,17 alpha,21-triol-20-one, a steroid lacking glucocorticoid or mineralocorticoid activity, was even more effective at inhibiting DNA synthesis by murine pulmonary capillary endothelial cells than was HAH-cortisol. In conclusion, HAH-cortisol represents the prototype of a new class of angiogenesis inhibitors for the treatment of cancer and other angiogenic diseases.

Animals↗
PubMed1993

Lymphangiography as a staging tool for cervix cancer: limited value after hip arthroplasty.

Lymphangiography (LAG) is often used in the work-up of cervical carcinoma. A patient with a history of bilateral hip arthroplasty, who presented with Stage IIIB squamous cell carcinoma of the cervix, was sent for lymphangiography. The LAG was deemed suboptimal, most likely because of altered lymphatic drainage engendered by the previous orthopaedic procedures. As the American population ages and hip arthroplasty becomes more common, the value of LAG in such patients will need to be reconsidered.

Aged↗
PubMed1993

Mood disorders in children with oppositional defiant disorder: a pilot study.

The nature and prevalence of comorbid mood disorders were explored in a group of 28 latency-age children diagnosed with oppositional defiant disorder. Findings are preliminary in nature but suggest that children with oppositional defiant disorder are at significant risk for low-grade depressive illness and that this may commonly be overlooked in the presence of their primary disorder's more overt symptoms.

Child↗
PubMed1993

An economic evaluation of varicella vaccine for pediatric liver and kidney transplant recipients.

To evaluate the potential benefit of varicella vaccine for pediatric liver and kidney transplant patients, we determined the consequences of varicella susceptibility for a cohort of susceptible children (n = 44) who received transplants between July 1986 and June 1990 at the Hospital for Sick Children, Toronto. Costs of these consequences were compared with costs with a hypothetical varicella vaccination program in place. The median follow-up was 11.4 months (range, 2-50 months). Total costs in Canadian dollars to the health service without a program were for varicella-related hospital stay ($135,675) and varicella-zoster immune globulin ($4,322). Costs to parents were for lost time ($13,590) and transport ($414). Assuming a vaccine cost of $30/dose and a 90% vaccine efficacy, a pretransplantation vaccination program would have cost $16,205 and saved $3,132/child ($304 for families and $2,828 for the health service) during the study period. Varicella vaccination prior to solid organ transplantation should reduce morbidity in pediatric recipients and provide considerable savings for families and the health system.

Adolescent↗
PubMed1993

Cerumen-impaction management for clients of all ages.

A cerumen plug in the external auditory canal can cause dizziness, pain, itching, ringing or decreased hearing. These symptoms are particularly distressing to elderly clients who may already have compromised hearing or be experiencing changes in functional ability. A cerumen plug that causes hearing impairments can retard children's educational and psychosocial development. This article focuses on the physiology of cerumen, the risk factors of cerumen plugs and the best way to remove cerumen in clients of all ages. The contraindications and complications of aural lavaging and instrument removal of cerumen are discussed. An ear-irrigation flow sheet is also included for ambulatory clinical use.

Cerumen↗
PubMed1992

The caregiver reaction assessment (CRA) for caregivers to persons with chronic physical and mental impairments.

The development and testing of a multidimensional instrument to assess the reactions of family members caring for elderly persons with physical impairments, Alzheimer's disease, and cancer is reported. Forty items were administered to a sample of 377 caregivers of persons with physical impairments and Alzheimer's disease. Five dimensions of caregivers' reactions were identified through exploratory factor analysis. Using confirmatory factor analysis on an independent sample (N = 377), these dimensions were tested for factorial invariance across spouse and nonspouse caregivers and between caregivers of persons with cancer and those caring for persons with Alzheimer's disease. The subscales also had a high level of factorial invariance across a three-wave panel study (N = 185). The subscales appeared consistent with first order tests of construct validity.

Aged↗
PubMed1992

Sonographic diagnosis of portal venous gas in two pediatric liver transplant patients with benign pneumatosis intestinalis. Case reports and literature review.

Pneumatosis Intestinalis (gas in the bowel wall) is uncommon in children and is associated with a number of clinical conditions most notably necrotizing enterocolitis in sick neonates. We observed portal venous gas on sonography and benign pneumatosis intestinalis on abdominal radiography in two children who had recently undergone liver transplantation. Asymptomatic portal venous gas and pneumatosis intestinalis has not been described previously in pediatric liver transplant patients. It is important to recognize the sonographic appearance of portal venous gas since sonography is the imaging modality most frequently utilized for monitoring the allograft post liver transplantation.

Child↗