Biomedical subjects

S Kiliaridis

Publications and source records attributed to S Kiliaridis.

At least 19 recordsLinked to original sources

PubMed2006

[Bone anchorage in orthodontics. A review].

The achievement of absolute anchorage in orthodontics overcoming the reaction forces and moments has been problematic for a long time. This was caused on the one hand by the limitations of the devices available and on the other hand by the dependence on patient cooperation. The introduction of bone anchorage systems changed the traditional way of thinking on orthodontic anchorage. Whereas the application of anchor systems, such as palatal implants and onplants, has specific indications, bone screws with or without plates seem to have the potential of being used on a routine basis. However, appropriate data for more complete understanding of the biological and biomechanical background of this concept of orthodontic anchorage are still lacking. Furthermore, studies on the effectiveness of these systems when compared to the traditional orthodontic anchorage and based on large groups of patients are not available. Well-designed prospective clinical trials substantiating the evidence-based use of these devices are needed.

Bone Screws↗

PubMed2005

Light curing time reduction: in vitro evaluation of new intensive light-emitting diode curing units.

The aim of the present in vitro study was to establish the minimum necessary curing time to bond stainless steel brackets (Mini Diamond Twin) using new, intensive, light-emitting diode (LED) curing units. Seventy-five bovine primary incisors were divided into five equal groups. A standard light curing adhesive (Transbond XT) was used to bond the stainless steel brackets using different lamps and curing times. Two groups were bonded using an intensive LED curing lamp (Ortholux LED) for 5 and 10 seconds. Two more groups were bonded using another intensive LED curing device (Ultra-Lume LED 5) also for 5 and 10 seconds. Finally, a high-output halogen lamp (Optilux 501) was used for 40 seconds to bond the final group, which served as a positive control. All teeth were fixed in hard acrylic and stored for 24 hours in water at 37 degrees C. Shear bond strength (SBS) was measured using an Instron testing machine. Weibull distribution and analysis of variance were used to test for significant differences. The SBS values obtained were significantly different between groups (P < 0.001). When used for 10 seconds, the intensive LED curing units achieved sufficient SBS, comparable with the control. In contrast, 5 seconds resulted in significantly lower SBS. The adhesive remnant index (ARI) was not significantly affected.A curing time of 10 seconds was found to be sufficient to bond metallic brackets to incisors using intensive LED curing units. These new, comparatively inexpensive, curing lamps seem to be an advantageous alternative to conventional halogen lamps for bonding orthodontic brackets.

Animals↗

PubMed2005

Tooth movement.

Explore the source record for details and available documents.

Age Factors↗

PubMed2004

The association between the masseter muscle, the mandibular alveolar bone mass and thickness in dentate women.

OBJECTIVE: Since muscle strength has been demonstrated to affect the bone in the long bones and spine, the possibility exists that the bone mass and dimension of the alveolar processes could be influenced by the function of the masticatory muscles. Therefore, the purpose of this study was to investigate whether two local factors (ultrasonographic masseter thickness, and occluding teeth) plus the skeletal bone mineral density (BMD) affect the mandibular alveolar bone mass (MABM) and the bucco-lingual alveolar thickness of the alveolar process. DESIGN: The thickness of the masseter muscle was evaluated by ultrasound imaging in 62 dentate women (40-75 years) with no periodontal disease and no dental infection in the premolar region consecutively selected from the patients in a public dental clinic. MABM was evaluated using periapical radiographs. The bucco-lingual thickness of the alveolar process was measured on dental casts with a dial calliper. BMD of the forearm was determined with dual energy X-ray absorptiometry. RESULTS: Multiple regression analyses demonstrated that masseter thickness and the number of occluding mandibular teeth in the lateral segment were significant determinants of MABM and of the interdental thickness, but BMD was not. The number of years after menopause and struma/gastro-intestinal disease influenced MABM but not the alveolar thickness. CONCLUSION: The local factors played an important role in the posterior mandibular segment and their effect might partly explain the low correlation between MABM and skeletal BMD.

Adult↗

PubMed2004

Effect of different masticatory functional and mechanical demands on the structural adaptation of the mandibular alveolar bone in young growing rats.

The influence of masticatory functional and mechanical demands on the structural adaptation of the alveolar bone has not been investigated in both animals and humans. The effect of two experimental factors, the insertion of a bite-opening appliance and the alteration of food consistency, was investigated in young growing rats, with a particular emphasis on three-dimensional (3D) bone microstructure. Thirty-six male albino rats were divided into two equal groups, fed with either the standard hard diet or soft diet, at the age of 4 weeks. After 2 weeks, half of the animals in both groups had their upper molars fitted with an upper posterior bite block, an appliance similar to those used in clinical orthodontics. The remaining animals served as a control. After another 4 weeks, the animals were sacrificed, and their left hemimandibles were excised. Bone mineral density (BMD) and bone microstructure parameters of the alveolar process were subsequently measured, using dual-energy X-ray absorptiometry (DXA) and micro-computed tomography (micro-CT). The alveolar process width was also measured. Both experimental factors led to significant shape and structure modification of the mandibular alveolar bone in the growing rat. The bite block applied a continuous light force, which was associated with an inhibition of alveolar process vertical growth and a significant increase of cortical thickness. Soft diet and the consequent reduction of the intermittent forces applied to the alveolar bone during mastication resulted in a reduction of bone mineral density, accompanied by decreased trabecular bone volume and thickness. This rat model could prove to be a useful tool for the in vivo investigation of the role of muscular forces on the shape and structure adaptation of bone.

Absorptiometry, Photon↗

PubMed2004

Long-term vertical changes of the anterior maxillary teeth adjacent to single implants in young and mature adults. A retrospective study.

AIM: To evaluate the effects of the tooth eruption process on the position of teeth adjacent to implant-borne restorations in adult patients compared to patients in their late adolescence. SUBJECT AND METHODS: The sample included 28 patients divided into two groups. A "young adult" group consisting of 14 patients, aged from 15.5 to 21 years, and a "mature adult" group consisting of 14 patients, aged from 40 to 55 years. All patients presented missing anterior teeth, requiring insertion of 40 implant fixtures (16 central incisors, 12 lateral incisors, 12 canines). The implants were of the Straumann Dental Implant System, clinically and radiologically re-evaluated 1 year or more after the surgical procedure (mean interval=4.2 years). Assessment of the eruption of the adjacent teeth was performed using the implant as a stable point of reference: measurements of the different reference points were compared after implant placement and at follow-up examination. RESULTS: In the "young adult" group, all patients showed infra-occlusion of the implant-supported crowns: the vertical step measured on radiographs varied between 0.1 and 1.65 mm. In the "mature adult" group, all patients showed a vertical difference between the teeth adjacent to the implant-supported crown and the implant: the measured step ranged from 0.12 to 1.86 mm. No difference was found in the amount of vertical eruption between male and female patients, nor according to localization of the implant. CONCLUSION: Mature adults can exhibit major vertical steps after anterior restorations with osseointegrated fixtures to the same extent as adolescents or "young adult" individuals with residuous growth potential.

Adolescent↗

PubMed2002

Macroscopic and roentgenographic anatomy of the skull of the ferret (Mustela putorius furo).

Normal macroscopic and roentgenographic features of the skull of the ferret (Mustela putorius furo) were examined and described. Data were based on a sample of 100 (50 male and 50 female) adult ferrets of known body weight and age. The skull was described macroscopically according to six standard views, i.e. dorsal, lateral, ventral, caudal, cranial and midsagittal. The mandible was described separately. The roentgenographic characteristics of the ferret skull were demonstrated only in lateral and dorsoventral projections. Furthermore, the skull length and width as well as the minimum frontal width were measured, and skull indices were derived from relevant measurements. Sexual dimorphism was examined both morphologically and craniometrically. Besides the common features of a carnivore skull, the ferret skull is relatively elongated and flat with a short facial region. The skulls of adult male ferrets are about 17% longer and 22% wider than those of the females. Significant sexual dimorphism also exists regarding certain skull indices. The general features and some dimensional parameters of the adult ferret skull support the contention that the ferret would be an interesting and workable alternative animal model in craniofacial research.

Animals↗

PubMed2001

Estimation of skeletal bone mineral density by means of the trabecular pattern of the alveolar bone, its interdental thickness, and the bone mass of the mandible.

OBJECTIVE: We sought to evaluate the use of the alveolar trabecular pattern, the mandibular alveolar bone mass (MABM) measured by photodensitometry, and the interdental alveolar thickness for prediction of the skeletal bone mineral density (BMD). STUDY DESIGN: MABM and the coarseness of trabeculation were assessed by using periapical radiographs in 80 dentate women. The interdental alveolar thickness was measured on casts, and BMD of the forearm with dual X-ray absorptiometry. RESULTS: Significant correlations were found between skeletal BMD and MABM (r = 0.46, P <.001) as well as the coarseness of the trabeculation (r = 0.62, P <.001). The interdental alveolar thickness improved the correlation between skeletal BMD and MABM (R2 = 0.44, P <.001). Age, but not interdental thickness, improved the correlation between the coarseness of trabeculation and skeletal BMD (R2 = 0.52, P <.001). CONCLUSION: Evaluation of the coarseness of trabeculation of the alveolar bone as seen on intraoral radiographs is a helpful clinical indicator of skeletal BMD and better than densitometric measurements of the alveolar bone. Dense trabeculation is a strong indicator of high BMD, whereas sparse trabeculation may be used to predict low BMD.

Absorptiometry, Photon↗

PubMed2001

Dentists' perception of risks for molars without antagonists. A questionnaire study of dentists in Sweden.

The aim of this questionnaire study was to investigate dentists' assessment of and the decision making process in a clinical situation with unopposed molar teeth. The questionnaire comprised, besides questions about the dentist's background, a presentation of a clinical situation with a 42-year old male patient who just had lost the left mandibular molars (teeth 36 and 37). A series of questions was provided with multiple choice answers regarding what most probably would occur with the unopposed maxillary molars within a 10-year period, what treatment to propose in such a situation, and indications for the proposed treatment. The questionnaire was sent to a randomly selected group of active members of the Göteborg Dental Society. Two hundred completed questionnaires were returned (response rate 72.5%). The great majority (85%) suggested that marked overeruption of the unopposed molars would occur, whereas 13% believed in minor changes. Almost half of the respondents (47%) proposed to wait and see before any treatment was started, whereas the remaining dentists wanted to perform some therapy as soon as possible or within a specified period of time. The most commonly suggested indications for treatment were risk for overeruption (79%), risk for impaired masticatory function (54%), and risk for development of TMD (50%). Differences in answers were found between female and male dentists, between specialists and general practitioners, and with respect to year of graduation. Most dentists believed that overeruption would occur in spite of the limited knowledge of what will happen to unopposed teeth.

Adult↗

PubMed2000

Pain in orthodontics. A review and discussion of the literature.

This literature review focuses on previous studies of pain and pain perception in dentistry with special emphasis on orthodontic treatment. The prevalence of pain and background factors such as age, gender and culture/society, in addition to pain physiology and the influence of concomitant emotional and cognitive factors, is examined. Pain during orthodontic tooth movement is reported from the point of view of its physiology and character and different assessment methods. These aspects are described both generally and specifically in relation to the type of orthodontic forces and to the experience of discomfort other than pain. Since the orthodontic treatment may cause some degree of suffering for the patients, it is important for orthodontists to handle this situation in the best possible way. Some ideas about the possibilities of avoiding, reducing or alleviating pain in orthodontics are discussed.

Humans↗

PubMed2000

Adaptation of normal and hypofunctional masseter muscle after bite-raising in growing rats.

The aim of this study was to analyze the effects of prolonged muscular elongation induced by bite-raising on the length of the muscle belly, sarcomeres and aponeurosis of the anterior deep masseter in the growing rat. Another aim was to determine the role of different functional conditions of this muscle in the adaptation process. Ninety-six young male rats were split into two groups: one was fed a hard diet and the other a soft diet to develop different functional capacities in the masticatory muscles. After 2 wk, half of the rats in both groups were fitted with an appliance that raised the bite by 2 mm. The measurements on the muscles were performed in situ. The insertion of the appliance stretched the anterior masseter muscle. After 4 wk, the vertical dentoskeletal dimension, the muscle belly, and the sarcomeres showed no difference in length among the groups. However, the aponeurosis was longer in the rats wearing the appliance compared to the controls, and among the bite block groups it was longer in the rats fed a hard diet. Length adaptation occurred in the aponeurosis. Clinically this may imply a need for reactivation of functional appliances to increase their efficiency, at a rate possibly depending on masseter muscles functional condition.

Acrylic Resins↗

PubMed2000

Changes in masticatory mandibular movements in growing individuals: a six-year follow-up.

The pattern of mandibular movement during chewing is influenced by several central and peripheral factors. The aim of the present study was to determine whether changes in masticatory function, characterized by mandibular velocity and displacement, occurred during individuals' normal growth. Forty-seven children, 9-15 years of age, were followed over a 6-year period. All had an Angle Class I occlusion with no obvious orthodontic problems. Oral motor function with respect to mandibular displacement, duration, and velocity was monitored 3-dimensionally with an opto-electronic method. The chewing cycle was divided into an opening, closing, and occlusal phase. Total body height was measured. During the follow-up period, all masticatory variables except the 3-dimensional opening distance showed significant changes. The total chewing cycle duration, the opening and occlusal time of the chewing cycle, and the 3-dimensional closing distance increased during the growth period, while the closing time of the chewing cycle, the 2-dimensional lateral and vertical distances and both the opening and closing velocity decreased. The children who grew proportionally most in height during the 6-year period, i.e. the youngest children in the group studied, showed a significantly larger decrease in the opening velocity. From this study it becomes evident that the variables of the chewing cycle undergo a continuous process of change during growth. This is possibly a reflection of anatomical changes, maturation of the central nervous system, and altered functional demands.

Adolescent↗

PubMed1999

Effect of low masticatory function on condylar growth: a morphometric study in the rat.

The aim of this study was to estimate the influence of functional alterations on the size of the mandibular condyle and to elucidate in detail, by means of histomorphometric analysis, the effect of changing the consistency of the diet on different portions of the condylar cartilage in growing rats. Forty growing rats were randomly divided into 2 groups. One group received the normal hard diet for rats; the other group received a standardized soft diet. The experimental period was 28 days. Ten animals from each group were used for gross morphometric analysis; the other 10 animals were used for histologic analysis of the condyle. The morphometric analysis of the condylar cartilage was based on the 25th, 50th, and 75th percentiles of the mediolateral sections of the condyles. The sections were divided into 3 parts: the anterior, intermediate, and posterior part; 4 measurements were performed in each. Significant differences were found in the condylar length and width between the groups, the soft diet group having a smaller condyle. The histomorphometric analysis of cartilage thickness showed significant differences between the 2 groups, being thinner in the anterior part and thicker in the posterior part of the condyle in the soft diet group. These routine histologic findings cannot explain the gross morphologic differences in the condylar size between the groups; this means that increased condylar cartilage thickness is not necessarily evidence of increased condylar growth. The results from this study indicate that a low masticatory function leads to decreased growth of the condyle and changes in the thickness of the cartilage. This may be the effect of an alteration in the stress distribution in the temporomandibular joint area, because of the absence of large masticatory forces.

Animals↗

PubMed1999

Effect of masticatory function on the internal bone structure in the mandible of the growing rat.

The influence of changes in the masticatory function on bone mass, bone density and cortical thickness was analyzed in different functional units of the mandible of the growing rat. Young male albino rats were fed either a hard diet or a soft diet for 4 wk. Undecalcified coronal sections were selected from five mandibular regions and microradiographic images of the specimens alongside an aluminium stepwedge were obtained. Bone mass and density were measured at selected sites with a computer-aided image analysis system. Cortical thickness was measured on diagrams. The reduced masticatory function in the soft diet group produced different adaptive responses in the tested regions of the mandible. Some regions showed reduced cortical thickness (underneath the incisor and lateral to the first molar and some locations of the ramus), a few showed reduced bone density (medial to the first molar and in the ramus), and only one showed both (in the ramus). Reduced bone mass was associated mostly with thinner cortical bone rather than lower cortical bone density. Changes in cortical thickness and changes in bone density may be two different mechanisms for adjusting local mechanical properties in the mandible of the rat. Masticatory muscle function is a determinant for the amount and density of cortical and trabecular bone and may possibly influence results of orthodontic tooth movement and its possible relapse.

Absorptiometry, Photon↗

PubMed1999

Cervical thickness of the mandibular alveolar process and skeletal bone mineral density.

Much effort has been devoted to finding methods for detecting individuals with low bone mass and risk of osteoporotic fractures. The aim of the present study was to investigate whether there is a relationship between the thickness of the alveolar process and the bone mineral density (BMD) of the distal forearm. In 24 women (38-65 years), the BMD of the distal forearm, obtained by dual X-ray absorptiometry, was correlated to the difference between two measures of the thickness of the mandibular alveolar process in the region of the first premolar. A highly significant correlation (r = 0.95, P< 0.001) was found. The method was cross-validated by using the equation obtained from the linear regression analysis above to predict BMD in two other groups. In both groups, the correlation between the measured BMD of the forearm and the predicted BMD was highly significant (r = 0.91, P< 0.001). The interdental thickness between the canine and the second incisor was also correlated to BMD, but with lower predictive value (r = 0.67, P<0.001). Measurements of the mandibular alveolar process can be used as one of several parameters to predict skeletal bone density.

Absorptiometry, Photon↗

PubMed1998

The effects of myotonic dystrophy and Duchenne muscular dystrophy on the orofacial muscles and dentofacial morphology.

This article takes a closer view of two of the less rare myopathies, myotonic dystrophy (MyD) and Duchenne muscular dystrophy (DMD). A high prevalence of malocclusions was found among the patients affected by these diseases. The development of the malocclusions in MyD patients seems to be strongly related to the vertical aberration of their craniofacial growth due to the involvement of the masticator, muscles in association with the possibly less affected suprahyoid musculature. Thus, a new situation is established around the teeth transversely. The lowered tongue is not in a position to counterbalance the forces developed during the lowering of the mandible by the stretched facial musculature. This may affect the teeth transversely, decreasing the width of the palate and causing posterior crossbite. The lowered position of the mandible, in combination with the decreased biting forces, may permit an overeruption of the posterior teeth, with increased palatal vault height and development of anterior open bite. The development of the malocclusions in DMD patients also seems to be strongly related to the involvement of the orofacial muscles by the disease. However, the posterior crossbite is not developed owing to the narrow maxillary arch, as is the case in MyD patients. On the contrary, the posterior crossbite in DMD is due to the transversal expansion of the mandibular arch, possibly because of the decreased tonus of the masseter muscle near the molars, in combination with the enlarged hypotonic tongue and the predominance of the less affected orbicularis oris muscle.

Biomechanical Phenomena↗

PubMed1996

Masseter muscle thickness in growing individuals and its relation to facial morphology.

It is widely accepted that an interaction exists between masticatory muscle function and craniofacial growth. In adults, correlations have been found between facial dimensions and jaw-muscle cross-sectional area, and between facial dimensions and masseter muscle thickness. Little is known about growth of the human masticatory muscles and its relation with facial dimensions at different ages. In 329 Greek individuals, aged 7-22 yr, masseter muscle thickness was measured by ultrasonography. Muscle thickness was related to age, stature and weight, and to facial dimensions, measured by means of anthropological calipers. Muscle thickness was statistically assessed by univariate analysis of variance, after the males and females had been divided into three age groups. Facial dimensions were assessed by multivariate analysis of variance, age being considered as a covariate. The relation between muscle thickness and facial dimensions was subjected to stepwise multiple regression analysis. Masseter muscle thickness increased with age in both sexes. No differences were found between the left- and right-hand side. For each age group (and corrected for stature and weight), males had significantly thicker masseters than females (p < 0.01). Variation in muscle size and facial dimensions mainly coincided with variation in age, stature and weight. Apart from these, muscle thickness showed a significantly negative relation with anterior facial height and mandibular length, and a significantly positive relation with intergonial width and bizygomatic facial width.

Adolescent↗

PubMed1996

Masticatory muscle activity in myotonic dystrophy patients.

The aim of the study was to compare the masticatory pattern and the activity of the masticatory muscles of a group of myotonic dystrophy patients with those of a group of healthy individuals. The electromyographic (EMG) activity of the temporal and the masseter muscles was measured in the resting position, during maximal clenching, and while the patient was chewing five peanuts until swallowing. It was found that the patients had approximately 3 times less EMG activity in the masticatory muscles during maximal clenching. During chewing the patients had approximately half the activity in the anterior temporal and the masseter muscles, while the activity of the posterior temporal muscle did not differ significantly from that in healthy individuals. No differences were found in the muscle activity in the resting position or in the speed of chewing between the groups. The patients needed more time and more chewing cycles to bring the five peanuts to the swallowing threshold, but possibly this was an effect of the lower number of antagonizing teeth. Myotonic dystrophy thus influences the masticatory muscles, reducing their activity both at a maximal and a functional level.

Adult↗