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Biomedical subjects

S Kijima

Publications and source records attributed to S Kijima.

At least 37 records · Page 2Linked to original sources
PubMed1987

CA 125 antigen is an effective diagnostic for external endometriosis.

We measured serum levels of CA 125 in 26 patients with external endometriosis, using CA 125 RIA Kits. The normal range was instituted below 39 U/ml. The mean CA 125 level (+/- SD) was 55.1 +/- 24.9 U/ml in patients with external endometriosis, the positive rate being 71.4%. Considering the clinical stage of external endometriosis, the mean CA 125 level and positive rate increased to 64.5 +/- 23.2 U/ml and 93.3%, respectively. The CA 125 levels in these patients gradually decreased after surgery and/or Danazol treatment and the levels were below 39 U/ml within four weeks. Thus, progressive external endometriosis can be accurately diagnosed by determining the serum levels of CA 125, and appropriate clinical treatment designed.

Adult↗
PubMed1986

Clinical usefulness and false-positive results of CA 125 as a tumor marker of ovarian cancer--a study on 674 patients.

To study the clinical usefulness and false-positive results of CA 125 as a tumor marker of ovarian cancer, we measured serum CA 125 levels in 197 patients with gynecological diseases, 274 normal, pregnant and postpartum women, 14 patients with abnormal pregnancy, 82 healthy women with a normal ovulatory menstrual cycle and 107 healthy non-pregnant subjects, using RIA kits. A level below 34 U/ml was considered the normal CA 125 range. The positive ratio of serum CA 125 in patients with malignant ovarian tumor was 81.3 per cent, and in those with serous cystadenocarcinoma the rate was 100 per cent. On the other hand, only one patient with benign ovarian tumor had a positive CA 125 value. Therefore, we suggest that CA 125 is useful for differentiation between benign ovarian tumor and ovarian cancer. However, because the positive ratio of CA 125 level is high in patients with recurrences of uterine cervical adenocarcinoma, those with tubal cancer, endometriosis, early pregnancy, abnormal pregnancy plus intrauterine fetal death and menstruating women, such situations must be given due attention when CA 125 is used as a tumor marker of ovarian cancer.

Antigens, Neoplasm↗
PubMed1986

[Study on the maintenance of the accuracy of cytological diagnosis in the mass screening of uterine cervical cancer].

We studied the effect of the centralized cervical cytological screening program in Shimane prefecture and obtained the following results. After the centralized screening system was introduced, the rate detection of dysplasia almost doubled. The detection rates for carcinoma in situ and invasive carcinoma of the uterine cervix increased from 0.042% to 0.047% and from 0.042% to 0.065%, respectively. The cases with Pap. class III, IV, and V decreased to a third on the centralized cytologic screening system. The false negative rates for carcinoma in situ and invasive carcinoma decreased from 20.0% to 17.9% and from 16.0% to 7.4%, respectively. We concluded that the accuracy of the cytological diagnosis was improved by the establishment of the centralized system.

Female↗
PubMed1985

[Differential diagnosis between leiomyomata uteri and adenomyosis using CA 125 as a new tumor marker of ovarian carcinoma].

To differentiate pre-operatively between leiomyomata uteri and adenomyosis, we measured serum levels of an antigen (CA 125) common to most nonmucinous epithelial ovarian carcinoma in patients with benign uterine tumor (11 of leiomyomata uteri, 7 of adenomyosis and 1 of adenomyosis with leiomyomata uteri). CA 125 in serum samples pre and postoperatively were measured using an RIA Kit. The normal range of CA 125 levels was below 35U/ml. The mean CA 125 level (+/- S.D.) was 18.3 +/- 6.1U/ml in patients with leiomyomata uteri and 93.3 +/- 49.4U/ml in those with adenomyosis. Student's t-test showed a significant correlation (0.001 less than p less than 0.01). The mean CA 125 level in patients with adenomyosis was statistically higher than that in disease-free women. Among 7 patients with surgically demonstrable adenomyosis, the CA 125 values were over 35U/ml (87.5%). In all 11 patients with surgically demonstrable leiomyomata uteri, the CA 125 level was below 35U/ml. The CA 125 level in patients with adenomyosis gradually decreased postoperatively and in all was below 35U/ml up to one month postoperatively. Using this approach, leiomyomata uteri and adenomyosis can be differentiated, pre-operatively.

Antigens, Neoplasm↗
PubMed1983

'Steady/equilibrium approximation' in relaxation and fluctuation. II. Mathematical theory of approximations in first-order reaction.

A mathematical theory of the steady/equilibrium approximation for first-order reactions is presented. This gives the theoretical basis for the methods of simplifying the complex first-order reactions described in the preceding work The steady/equilibrium relation holds on every fast component after a proper inducation period T degrees T degrees is either of O(1) or less, or nearly of O(1/epsilon) depending on the reaction scheme and on the initial condition but is always less than O(1/epsilon) (as in the preceding paper [1], we use the symbol O(1) to denote a positive number of the order of unity). In the open group, the determinant of the submatrix M(p), representing the interconversion between the fast components in the group and their dissipation, is of O(1). The concentration of the fast components in the open group can thus be expressed as a linear combination of those components neighboring the group after the establishment of a steady/equilibrium relation, and can be eliminated from the reaction scheme leaving the pathway through them. On the other hand, in the closed group the determinant of Mp is of O(epsilon) or less and the components in the group are in quasi equilibrium with each other after T degrees . They are eliminated from the reaction scheme leaving the sum of the components in the closed group as a slow component.

Journal Article↗
PubMed1982

'Steady/equilibrium approximation' in relaxation and fluctuation. I. Procedure to simplify first-order reaction.

A general procedure to simplify a complex first-order reaction by two approximations, the principle of fast equilibration and the steady-state approximation, is presented. Rate constants are classified into two groups: those of the order of unity and those of the order of epsilon (much less than 1) or less, and are represented in the schemes by thick and thin arrows, respectively. The fast and the slow components are defined: from the fast component at least one thick arrow originates and from the slow component no thick arrow originates. Fast components are divided into several groups. In a group, the fast components are connected by thick arrows in both directions in each reaction step. When at least one thick arrow originates from the components in a group G and terminates on a component not belonging to group G (group G is open), then the steady-state approximation or principle of fast equilibration holds on each component in group G after an induction period To. When no thick arrow originating from group G is directed to components not belonging to group G (group G is closed), the principle of fast equilibration holds on the fast components in group G after To. The induction period To is less than the order of 1/epsilon.

Kinetics↗