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Biomedical subjects

S Kern

Publications and source records attributed to S Kern.

61 records · Page 4Linked to original sources
PubMedDate not supplied

[Ceramic head fracture--a rare complication in hip endoprosthesis. Case report and literature survey].

Since introduction of the prosthetic joint replacement numerous design modifications have taken place. Some were successful other were given up after short time. During almost twenty years now in joint arthroplasty of the hip components made of A12 03-ceramics--ball and/or socket--are used. Many papers have reported about the results of these implants. One of the possible complications described in the literature is the breakage of the ceramic component(s). Since April 1981 we have implanted over 500 cementless prosthesis of the hip in combination with a ceramic ball. In one patients we observed a breakage of the head two years after implantation. We will describe the story of this case and discuss possible reasons for this complication in reference to the literature.

Ceramics↗
PubMedDate not supplied

[The Balgrist hip cup--a 4-to-10-year survival analysis of cement-free hip cups].

The results of 715 cement-free acetabular sockets used in primary total hip arthroplasties are shown according to a survivorship analysis after Kaplan-Meier. The survival probability of the examined cement-free polyethylene sockets after 5 years lies between 88.1% and 93.6% (Endler screw socket of polyethylene: 93.6%; Balgrist socket of polyethylene: 88.1%; Balgrist socket of polyethylene with titanium coating: 90.6%). The survival probability of the Endler socket after ten years is only 44.2%. No statistically significant difference in the survival curves of the polyethylene socket models could be found (p logrank 0.797). The Balgrist sockets with the outer split ring made of titanium show a far better survival rate (98.8% after 4 years) than those made of polyethylene. This result justified the further development of a Modular Revision socket made of titanium so that the original idea could be extended to revision interventions where large acetabular defects have to be coped with.

Acetabulum↗
PubMedDate not supplied

[Lunate malacia and the Swanson endoprosthesis].

The etiology and the treatment of the aseptic necrosis of the lunate bone (M. Kienböck) is still today debated. In the literature we find more than twenty different procedures of treatment. Our follow-up of seven patients with Swanson Lunatum prosthesis showed subjectiv and functional good results whereas the radiological findings weren't satisfactory.

Adult↗
PubMedDate not supplied

The genotoxicity of unsubstituted and nitrated polycyclic aromatic hydrocarbons.

To determine the DNA damaging properties of unsubstituted and substituted polycyclic hydrocarbons, 61 aromatic and heterocyclic compounds were examined for the induction of the SOS system in E. coli PQ37. PAH such as benzo[ghi]fluoranthene, benzo[j]fluoranthene, benzo[c]phenanthrene, benzo[a]pyrene, chrysene, dibenzo[a,1]pyrene, fluoranthene and triphenylene showed relatively high genotoxicity. With respect to the nitroarenes, the highest genotoxic potencies were exhibited by the dinitropyrenes. The SOS-inducing potency of nitroarenes increased from the bicyclic to the tetracyclic ring system. Additionally, it was seen that any increase in the extent of nitration is paralleled by an increase of genotoxicity. Whereas PAH required metabolic activation by hepatic cytochrome P-450 enzymes, nPAH were direct-acting genotoxicants.

Animals↗