A series of automated instruments that use state-of-the-art chemical methods has been developed for high-sensitivity protein sequencing, DNA synthesis and peptide synthesis. These instruments have been integrated into a centralized microchemical facility in order to promote their use for the study of a variety of biologically interesting problems. This facility has as one of its major functions the development of new chemistries and instrumentation for the structural analysis and synthesis of genes and proteins.

Amino Acid Sequence↗

PubMedDate not supplied

No Limits. Politics: corporate minefield.

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Coal Mining↗

PubMedDate not supplied

Interpretations of differences in population hemoglobin means: a critical review of the literature.

Numerous large-scale studies have conclusively established that North American blacks have a lower population mean of serum hemoglobin concentrations than North American whites. An increasing number of researchers interpret the reduced hemoglobin levels as a genetic racial trait and recommend lowering the normal range for blacks. However, other hematological parameters among blacks indicate an alternative view. The same medical surveys also document higher ESR (erythrocyte sedimentation rate) and higher serum ferritin means in the black population. These, in association with low hemoglobin levels, are the definition of the anemia of chronic disease. A range of disorders, from infectious and inflammatory diseases to neoplasia, lead to the anemia of chronic disease. The prevalence of this hematological profile in North American blacks may indicate that the population has a higher morbidity than whites. A literature review suggests that these particular hematological means differ from whites, regardless of socioeconomic class, because of increased frequency and virulence of disease among blacks. The increase appears to be the consequence of social, rather than racial, causes.

Anemia↗