Search PubMed⌕ Search

Biomedical subjects

S Kennedy

Publications and source records attributed to S Kennedy.

At least 325 records · Page 18Linked to original sources
PubMed1983

Respiratory mucosal permeability in asthma.

The permeability of respiratory mucosa to technetium-labeled diethylenetriamine pentacetic acid (99mTc-DTPA) was measured in 10 clinically stable chronic asthmatics and the results were compared with those in 9 nonasthmatic control subjects. Nonspecific bronchial reactivity was measured using methacholine, and the PC20 was calculated. The intrapulmonary distribution and dose of the inhaled 99mTc-DTPA was determined by a gamma camera and the half-life of the aerosolized label in the lung was calculated. The accumulation of radioactivity in the blood was monitored and a permeability index was calculated at 10, 25, and 60 min after aerosolization. Despite marked differences in airway reactivity, no differences in either parameter of permeability could be detected between the asthmatics and the control group. It is concluded that clinically stable asthmatics do not demonstrate increase mucosal permeability to small solutes when compared with normal subjects.

Adult↗
PubMed1983

Life events precipitating mania.

A study of 20 manic patients, with patient and matched control comparisons, showed a two fold increase in life events during the 4 month period before admission to hospital. Life events, independent of affective illness and having significant objective negative impact (i.e. traumatic) were significantly more common. These findings are considered in relation to social relationships, family history of affective illness and the use of psychotropic medication.

Adult↗
PubMed1983

Depression in chronic schizophrenia.

Eighteen depressed chronic schizophrenic out-patients were matched with non-depressed schizophrenic out-patients. The depressed schizophrenics had had significantly more psychiatric admissions, past depression, past treatment for depression, significantly more had attempted suicide, lived alone, had low self-esteem, had early parental loss and had had more life events in the six months before the onset of depression. Depressive disorder in schizophrenic out-patients well controlled by neuroleptics may occur in those who are at risk for depression and experience an excess of life events.

Adult↗
PubMed1983

Human neurophysins in carcinoma of the lung: relation to histology, disease stage, response rate, survival, and syndrome of inappropriate antidiuretic hormone secretion.

At diagnosis, 65% of 103 patients with small cell carcinoma of the lung were found to have elevated plasma concentrations of vasopressin-associated human neurophysin (VP-HNP), oxytocin-associated human neurophysin (OT-HNP), or both, which were thought to be related to tumor secretion of these proteins. The remainder of patients were designated as nonsecretors (24%) or possible secretors (11%), depending upon plasma concentration of the neurophysins prior to therapy. There was a significantly higher percentage of secretors among patients with extensive disease (82%) than among those with limited disease (40%) (P = 0.001). However, within each stage group, there was no correlation between secretory status and response to therapy, survival, or histologic subtype. In addition, patients who initially were nonsecretors or possible secretors maintained this status throughout the course of disease remission and subsequent relapse. These findings suggest the possibility of biochemical differences between tumors which present as limited disease and those which present as extensive disease. The syndrome of inappropriate antidiuretic hormone secretion (SIADH) was infrequent in limited disease but was present in 33% of patients with extensive disease. SIADH was not seen without VP-HNP elevation; however, with extensive disease, 49% of patients with elevated VP-HNP had SIADH. In contrast, elevated plasma concentrations of the neurophysins were seen in only 19.6% of 56 patients with non-small cell carcinoma of the lung. The levels were in general lower than those in patients with small cell carcinoma and were seen at approximately equal frequencies in each major cellular subtype.

Adenocarcinoma↗
PubMed1982

Uncinariasis in kennelled foxhounds.

Uncinariasis was diagnosed as the cause of unthriftiness in kennelled foxhound pups. Post mortem examination of two pups revealed large numbers of Uncinaria stenocephala embedded in the mucosa of the distal small intestine. The worms were associated with blunting and thickening of villi in this region. The stereoscopic appearance of U stenocephala as seen by scanning electron microscopy is described.

Ancylostomatoidea↗
PubMed1980

Simultaneous stereoscopic fundus camera incorporating a single optical axis.

The method of stereoscopic fundus photography, where both photographs are taken simultaneously, yields the most consistent and reproducible record of depths in the fundus. However, all systems devised to date have had undesirable photographic aberrations. For the most part, this has resulted because the optical axis of each image is not the same as that of the objective lens. A single-axis system has now been devised to minimize distortions in the stereoscopic photographs, which therefore makes stereophotogrammetry relatively simple. This design also has other advantages such as simplified alignment procedures, the use of Barlow lenses for multiple magnifications, and various paired apertures for obtaining photographs especially adapted to unusual situations.

Fundus Oculi↗
PubMed1978

Laparoscopy in zoological medicine.

The technique of laparoscopy was adapted and utilized in zoological medicine for various mammals, birds, and reptiles for reproductive and diagnostic studies as well as clinically related research. It was concluded that since anesthesia was routinely required for most manipulative procedures in zoo animals, and since laparoscopy adds little additional risk, the use of this technique provides an additional diagnostic aid when indicated. Laparoscopy was found to be effective for evaluating reproductive status, particularly ovarian anatomy and function, direct visual biopsy of internal organs, sex determination in selected birds, and as a surgical means of fertility control.

Animals↗
PubMed1978

Ventriculostomy for removal of foreign bodies from sarus cranes.

Of 7 captive sarus cranes (Grus antigone) that ingested foreign metallic objects, 3 became ill, and 1 of the 3 died. Clinical signs included difficulty in standing, sitting on hocks, and diarrhea. A surgical approach was developed, using pigeons as models, to open the gizzard for removal of the foreign bodies. The surgery was performed successfully 3 times on 2 of the cranes that had signs of illness.

Animals↗
PubMed1978

Suppurative arthritis in an infant orangutan.

A 12-day-old male orangutan (Pongo pygmaeus) was removed from its mother because of oral ulcers and reluctance to suckle. Close examination revealed ulcerations extended to the mandibular bone. Staphylococcus aureus was cultured from the oral lesions. Despite intensive antibiotic therapy, the infection progressed to septicemia, with suppurative arthritis of the left coxofemoral and right radiohumeral joints. Treatment included removal of synovial exudate by aspiration, indwelling drains, and arthrotomy. Antibiotics were administered systemically and by joint irrigation. The infant responded well to the treatment, which lasted for approximately 2 months.

Ampicillin↗
PubMed1978

Ganglioside and morphological changes in mouse embryo cells with time.

Ganglioside and morphological changes were observed in C3H/10T1/2CL8 cells during a 4-year period of maintenance in the laboratory. The cellular morphology at confluency, as determined by scanning electron microscopy, changed from being polygonal and flattened to a fusiform shape with some piling up of cells. The saturation density increased about three-fold and the level of the simplest ganglioside GM3 (N-acetylneuraminylgalactosylglucosylceramide) increased about two-fold. While the reasons for the alterations are unknown, the data suggest a relationship among ganglioside composition, cellular morphology and regulation of cell growth. The possible implications of such biochemical and biological changes on studies comparing normal and transformed cells are discussed.

Cells, Cultured↗
PubMed1977

Lead poisoning in sandhill cranes.

Seven Florida sandhill cranes (Grus canadensis pratensis) and 6 greater sandhill cranes (Grus canadensis tabida) were exposed to lead-base paint containing 27% lead. One bird of each subspecies died enroute to the hospital, with a clinical history of anorexia, weakness, and open-mouth breathing of 36 hours' duration. There were no gross lesions, and microscopic lesions were limited to focal hepatic necrosis and hemosiderosis. Two of each subspecies of cranes developed clinical signs of lead poisoning, which included anorexia, weakness, green diarrhea, regurgitation, and open-mouth breathing. Diagnosis of lead poisoning was confirmed on the basis of blood lead concentrations ranging from 146 microgram/100 ml to 378 microgram/100 ml. These 4 cranes were treated successfully with calcium disodium edetate intramuscularly. Seven of the birds remained clinically normal despite high blood lead levels, especially in the greater sandhill cranes.

Animals↗
PubMed1977

Hematologic effects of xylazine when used for restraint of Bactrian camels.

Xylazine was found to be a safe and reliable drug for chemical restraint of Bactrian camels (Camelus bactrianus). Dosages of 0.27 to 0.51 mg/kg of body weight provided adequate sedation for the performance of various procedures (e.g., tuberculin testing, lymph node biopsy, and electroejaculation). Hematologic and serum biochemical values for camels restrained manually were compared with those for camels restrained with xylazine. Xylazine-treated camels had significantly lower values for RBC, hemoglobin, and packed cell volume, and significantly higher blood glucose concentrations. Venous blood gas analyses did not reveal any major acid-base disturbances resulting from the use of xylazine. Rapid arousal from the sedative effects of xylazine occurred after the intravenous administration of doxapram hydrochloride in dosages of 0.05 to 0.13 mg/kg of body weight.

Animals↗
PubMed1977

Left ventricular endomyocardial biopsy. III: ultrastructural characteristics of cardiomyopathy and cardiac hypertrophy with good or poor ventricular function.

Left ventricular endomyocardial biopsies have been obtained from patients with cardiomyopathy and hypertrophy due to aortic valve disease. These biopsies have been examined by electron microscopy and the ultrastructural abnormalities compared. In congestive cardiomyopathy no specific abnormalities were found although myofibrillary degeneration and membrane-bound vacuoles were more commonly present. Crossing of whole groups of sarcomeres was found only in asymmetric septal hypertrophy, but was not present in all cases. Amyloid deposits were demonstrated easily by electron microscopy in patients with restrictive cardiomyopathy. In the patients with hypertrophy due to aortic valve disease, no specific features were found and ultrastructural abnormalities did not differentiate between normal and impaired left ventricular functions.

Aortic Stenosis, Subvalvular↗