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Biomedical subjects

S Kelly

Publications and source records attributed to S Kelly.

295 records · Page 17Linked to original sources
PubMedDate not supplied

Fish-oil-containing diet and platelet aggregation.

Current research suggests that a diet high in fish oil may be useful for immunomodulation in hospitalized patients. However, one of the side effects of fish oil is a prolongation of the bleeding time, specifically by reducing platelet aggregability. Although this effect might be beneficial for patients with cardiovascular disease, it would be a potential concern in certain critically ill patients. To address this concern, we conducted a prospective study of platelet aggregation in 16 surgical patients who were randomly assigned to receive either a diet containing 16.5 g of fish oil in 1500 ml (Impact) or usual care (standard enteral formulas devoid of fish oil). Feeding was successfully accomplished in the patient group receiving a diet that provided approximately 14.2 g of fish oil/day for 1 wk without significantly affecting platelet aggregability. Thus, it appears that, over the short term, this dose of fish oil does not alter platelet function in hospitalized surgical patients.

Adult↗
PubMedDate not supplied

Investigation of cyclic depsipeptides by fast atom bombardment-mass spectrometry.

In recent years, the synthetic analogue elcatonin has been used successfully in the treatment of osteoporosis. During an investigation of synthetic strategies for the production of elcatonin, a number of peptide products were generated. These could be purified by liquid chromatography and were shown to have identical amino acid compositions. Investigation by fast atom bombardment-mass spectrometry revealed three of the peptides to have a common pseudomolecular ion but notably dissimilar fragmentation patterns. Further studies involving chemical modification, mass spectrometry and chromatographic separation showed these products to be novel depsipeptides, cyclized with an ester bond between either the serine or the threonine residue and the side chain of aminosuberic acid.

Amino Acid Sequence↗
PubMedDate not supplied

Geographic concentration of violence between intimate partners.

OBJECTIVES: To explore geographic patterns of violence between intimate partners in a metropolitan area with one of the highest injury mortality rates in the nation-Duval County, Florida, which includes the city of Jacksonville. METHODS: Using police reports of all serious violent incidents in Duval County in 1992 excluding robberies, the authors analyzed patterns in the location of the incidents. Only cases for which the relationship between the offender and victim was recorded were used. RESULTS: Thematic maps reveal that census tracts with rates above the 75th percentile of assaultive violence between intimates are clustered in certain parts of the city. Concentrated poverty tracts had median rates of violence between intimate nine times higher than other tracts. CONCLUSIONS: The finding that violence between intimate partners is concentrated in central city poverty neighborhoods opens up avenues for prevention.

Adult↗
PubMedDate not supplied

Use of seat belts in a Dublin area.

This study examines public compliance with seat belt regulations. Two busy suburbs in north Dublin were studied. Of the 2,139 vehicles surveyed 1,160 (54.2%) drivers wore a seat belt. Young female drivers were most likely to comply with the regulations (70.1%). Only 344 (46.1%) front seat passengers wore their seat belt. 188 children who appeared to be under 10 years of age were observed in the front seat of vehicles and of those just 9 babies were appropriately restrained. Of the back seat passengers 108 (19.2%) wore seat belts; 99 (21.8%) children and 9 (9.8%) adults. Despite on-going publicity and progression in the regulations our use of seat belts is grossly disappointing. Road traffic accidents exert an unacceptably high toll on health in Ireland. Seat belts are known to be effective in preventing serious injury. A much greater emphasis on enforcement of legislation is now urgently needed to encourage responsible behaviour among vehicle users and to reduce the needless suffering due to road traffic accidents.

Adolescent↗