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Biomedical subjects

S Kawaguchi

Publications and source records attributed to S Kawaguchi.

At least 325 records · Page 18Linked to original sources
PubMed1977

The further investigation on the gastric acid secretion in the primary hyperparathyroidism.

The gastric acid output was studied in the 11 patients of hyperparathyroidism before and after parathyroidectomy. The gastric acid output before operation was almost equal to the normal control in our hospital. After the correction of serum calcium by parathyroidectomy, the gastric acid output and serum gastrin were decreased. The decreased gastric acid output was recovered as the days passed since operation and approached to the preoperative level. The acid output in hyperparathyroidism was less in the case whose activity of alkaline phosphatase was more, which suggested that the calcium deposition on gastric mucosa might damage the parietal cell as the result of long lasting hypercalcemia.

Adolescent↗
PubMed1977

[Ventriculography with non-ionic water-soluble contrast medium, Amipaque (metrizamide)-experimental and clinical study (author's transl)].

The excellently low toxicity of a non-ionic watersoluble contrast medium Amipaque (Metrizamide), which is used for ventriculography, was confirmed by animal experiment and clinical application. In the animal experiment, 20 adult mongrel dogs were used and in each of them 1.5-5.0 ml of Amipaque was injected intraventriculary or intracisternally. As a result, we obtained a finding that the Amipaque is cleary safe compared with other watersoluble contrast media, espcially on epileptogenicity, while having an effect on the definition of picture and the nature of cerebrospinal fluid similar to other watersoluble contrast media. Thereafter, 14 ventriculographies were performed for 11 neurosurgical patients by using 4-10 ml of amipaque. Though one patient complained of a light headache after the examination, in no cases could convulsive complication be observed. The experience of this new medium gave us an impression that ventriculography with watersoluble contrast media will take the place of pneumoventriculography.

Adolescent↗
PubMed1976

Electrophysiological studies on the cerebellocerebral projections in monkeys.

1. Responses evoked by stimulation of the cerebellar and thalamic nuclei were recorded by microelectrodes introduced at various depths in the cerebral cortex of monkeys (Macaca mulatta) under light Nembutal anaesthesia. 2. Stimulation of the medial (fastigial) cerebellar nucleus produced, at a latency of 4-5 msec, deep thalamo-cortical (T-C) responses (surface positive-deep negative potentials) mainly in the medial part of the precentral gyrus (area 4, "motor area for hindlimb") and in the superior parietal gyrus (area 5) on both contralateral and ipsilateral sides to the nucleus stimulated. 3. Stimulation of the lateral (dentate) cerebellar nucleus elicited, at a latency of about 3 msec, superficial T-C responses (surface negative-deep positive potentials) predominately in the lateral part of the precentral gyrus (area 4, "motor area for forelimb and face") and in the rostromedial part of the gyrus (area 6, premotor area) on the contralateral side. 4. Stimulation of the interpositus cerebellar nucleus set up superficial T-C responses chiefly in the motor area between those influenced by the medial and the lateral cerebellar nucleus stimulation and also in the premotor area on the contralateral side. 5. The respective areas responsive to the medial, interpositus and lateral nucleus stimulation overlapped considerably each other in the motor cortex. 6. Comparison of the responses in the cortex induced by stimulation of the cerebellar and thalamic nuclei indicated different relay portions in and around the VA-VL region of the thalamus for the superficial and the deep T-C responses respectively. 7. Functional implications of the results were discussed in referring to the cerebellocerebral projections in cats.

Animals↗
PubMed1976

Ventriculography with methylglucamine iocarmate (Dimer-X). Experimental and clinical study.

In an attempt to study the use and value in ventriculography of meglumine iocarmate (Dimer-X), previously accepted as a water soluble contrast medium safe for myelography, we have conducted animal experiments to compare Dimer-X with megulumine iothalamate (Conray 60) and meglumine diatrizoate (Angiografin). We also made clinical studies of Dimer-X. In the animal experiments, 1.5 ml and 2.0 ml of Dimer-X were injected into the ventricles of 7 dogs. We noted the apparent superiority of Dimer-X over Conray 60 and Angiografin as far as side effects were concerned, but there were no particular differences in the intensities of the ventriculograms obtained. Morphological studies of the ventricles and histological examinations of the ventricular walls 1 month after intraventricular injections of Dimer-X showed no abnormalities. In the clinical studies, ventriculography with 1-5 ml Dimer-X, performed on 17 cases, aged 8 months to 62 years, with diseases of the central nervous system, produced ventriculograms of good diagnostic value with no side effects, such as convulsions, apart from mild headache or vomiting in 4 instances.

Animals↗
PubMed1976

Transition in the character of immunological memory in mice after immunization. I. Memory for IgM and IgG antibody responses.

The immunological memory in antibody response of mice to bovine serum albumin was investigated at the level of IgM and IgG antibody-forming cells, The antigen at a dose much lower than required for eliciting a detectable level of the primary antibody response could latently activate the immune machinery to an extent adquate for specific recall, whereas higher doses of antigen were effective in evoking strong anamnestic response. The potentiality to develop the anamnestic response was found even in the latent phase of the primary antibody response and was maintained for more than 2 months. The immunological memory acquired in an early phase after the primary immunization mainly involved IgM antibody response and late memory concerned IgG response.

Animals↗