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Biomedical subjects

S Kawada

Publications and source records attributed to S Kawada.

At least 145 records · Page 8Linked to original sources
PubMed1990

[Fontan-type operation in a 14-month-old patient with tricuspid atresia who had [I, D, D], pulmonary atresia and right pulmonary artery stenosis].

A 14-month-old male with tricuspid atresia who had [I, D, D], pulmonary atresia, right pulmonary stenosis and a Blalock-Taussig shunt successfully underwent a Fontan-type operation accomplished by making a direct right atrial-pulmonary arterial connection with a Gore-Tex roof patch. The patient had an uneventful postoperative course without development of the heart failure.

Heart Atria↗
PubMed1989

[Pathological findings of the aortic wall at the site of ligation against the rigid rings of an intraluminal graft for acute DeBakey type I aortic dissection].

A ringed intraluminal graft has been utilized in the surgical treatment for dissecting aneurysm since 1978. Histological findings of the aortic wall long after surgery, however, have not been described in detail, and concern remains about possible pressure necrosis at the point of encirclement. The following report is for a case of acute type I aortic dissection which required the use of an intraluminal surgical graft in a patient who died eight months postoperatively of a disease unrelated to previous surgical management. The pathological findings at autopsy were as follows. At the site of circumferential ligations around the aorta, 1) discontinuity of the elastic fibers in the media was found only at the outer surface, 2) there was no compression necrosis in the outer half of the media, although a dark shade of elastic fibers was recognized, 3) there were no pathological changes in the inner half of the media. In addition, complete repair of the intimal tear as well as closure of the false lumen replaced by collagen fibers was confirmed histologically in the whole length of aorta where the intraluminal graft had been placed. We conclude that concerns about the fragility of the aortic wall at the site of circumferential ligation, the migration of prosthesis, and the formation of thrombi is alleviated by these pathological observation.

Acute Disease↗
PubMed1989

[A case of mediastinal cystic lymphangioma--case reports and review of the literature in Japan].

A 15-year-old woman was admitted to our hospital with complaints of left anterior chest pain and an abnormal shadow on her chest X-ray film. At the left thoracotomy, a large cyst (20.5 x 15 x 3 cm) was located in the left anterior mediastinum and contained translucent yellow fluid. Histological diagnosis was cystic lymphangioma. Mediastinal cystic lymphangioma is very rare among mediastinal tumors. Altogether 32 cases of mediastinal cystic lymphangioma including our case were collected from the Japanese literature and reviewed.

Adolescent↗
PubMed1989

[Influences of irradiation on the anastomotic sites of artificial grafts].

To examine the acute influences of irradiation on the anastomotic sites of EPTFE vascular grafts, an experimental study was performed using dogs. After replacement of superior vena cava and bilateral femoral arteries with EPTFE grafts, a total of 20 to 100 Gy doses were given at the anastomotic sites of superior vena cava and right femoral artery. There was no degradation of grafts themselves or rupture in the anastomoses at cumulative radiation doses of 20 to 100 Gy. However, in many dogs, receiving over 50 Gy doses at the anastomotic sites of superior vena cava, stenoses and/or overgrowth of granulation tissues were observed, although at those of right femoral artery, no remarkable differences were observed between dogs which received and those which did not receive irradiation.

Anastomosis, Surgical↗
PubMed1988

Interactions between UFT and anticoagulants in lung cancer patients.

In order to study the interactions between UFT and anticoagulants, the plasma and tissue concentrations of 5-FU, uracil and FT-207 were examined in patients with lung cancer. Higher plasma concentrations of 5-FU and uracil were observed in the patients who were given warfarin and ticlopidine beforehand, whereas the concentrations of FT-207 were almost the same in the patients who were given anticoagulants as in those who were not. This may be interpreted as an inhibition of dihydrouracil dehydrogenase, the common metabolizing enzyme of 5-FU and uracil, by anticoagulants. With regard to the tissue concentrations, higher levels of 5-FU and uracil in the tumor and lymph nodes were obtained after anticoagulants were given beforehand. Concentrations of FT-207 in these tissues, however, were almost the same in the patients who were given anticoagulants as in those who were not. We thus concluded that an increase of 5-FU in tumor cells and lymph nodes can be achieved after elevating the plasma concentrations of ordinary oral doses of UFT by using anticoagulation therapy beforehand.

Aged↗
PubMed1988

[Diffuse B-cell lymphoma of anterior mediastinum cured by short-term administration of CDDP-containing regimen].

The following report is of a case of diffuse B-cell lymphoma of the anterior mediastinum that was originally treated by resection and radiation in a patient who had pleural and subcutaneous metastases four months after operation. A total dose of 120 mg of CDDP, 60 mg of BLM, and 15 mg of VBL was administered in five weeks. The metastases completely disappeared by this dose alone, and the patient is alive and well seven and a half years after the chemotherapy.

Adolescent↗
PubMed1988

[Experimental and clinical study of interactions between fluorinated pyrimidine derivatives and anticoagulants].

Interactions between fluorinated Pyrimidine derivatives and anticoagulants were studied experimentally and clinically, using transplanted tumor tissues of Donryu rats and tissues from lung cancer patients. In rats, which were given 5-FU, uracil, tegafur and UFT respectively, the higher tumor concentrations of 5-FU and uracil were observed when given warfarin and ticlopidine beforehand, on the other hand, the concentrations of tegafur were almost the same between rats with and without anticoagulants. In patients with lung cancer, who were given UFT and anticoagulants, the higher concentrations of 5-FU and uracil in plasma, tumor and lymph nodes were observed than those who were given UFT alone. The 5-FU concentrations in normal lung tissues were about a half of those in tumor. These results suggest a existence of the synergistic effects between fluorinated pyrimidine derivatives and anticoagulants in plasma and tissue concentrations of 5-FU.

Animals↗
PubMed1988

[Clinical results of UFT plus anticoagulants as a postoperative adjuvant in lung cancer patients].

Warfarin, Ticlopidine and UFT as postoperative adjuvant have been administered patients with stage III and IV lung cancer who underwent surgical resection. In a controlled trial, 55 patients were divided into two groups, one with anticoagulants and UFT (27 cases), the other with UFT alone (28 cases). The prognoses of the two groups were followed for 6 years. The anticoagulant group demonstrated a statistically greater interval from operation to recurrence the control group, although the recurrence rates and the interval from recurrence to death were almost the same between the two groups. Survival rates of anticoagulant group were always superior to those of control group after 12 months postoperatively, and the median survival was about twice that of the control group. Although survival rates between the two groups revealed no statistical difference, in patients with adenocarcinoma, the difference between the two groups was statistically significant.

Anticoagulants↗
PubMed1988

[Early detection of central nervous system dysfunction during cardiopulmonary bypass using EEG monitoring].

The EEG was monitored in fifty-four patients during and after various surgeries requiring cardiopulmonary bypass (CPB) to assist in the early detection of central nervous system dysfunction (CNSD). Bilateral frontopolar EEG signals were processed with a 2-channel, real-time Fast-Fourier-Transformer (FFT) analyser and Compressed Spectral Arrays (CSA) were obtained. The fifty-four patients were divided into 3 groups based upon clinical outcome; Group 1: patients without CNSD (83%); Group 2: patients with delayed recovery from anesthesia but without CNSD (4%); and Group 3: patients with apparent postoperative CNSD (13%). There was no difference in the CSA among these groups prior to rewarming, but after the rewarming phase, two distinct sets emerged. Groups 1 and 2 showed a shift of the CSA predominant peak from a low frequency to a higher frequency. On the other hand, Group 3 patients demonstrated either stable predominant peaks in the lower frequencies or gradual flattening of the CSA. We conclude that the intra-operative EEG monitoring is a useful tool for the early detection of CNSD during and after CPB.

Adult↗
PubMed1987

Relation of ABH blood group antigen expression to prognosis in lung carcinoma.

The ABH blood group antigens were studied in resected specimens from patients with lung cancer employing monoclonal antibodies against A, B and H antigens by the immunoperoxidase technique. There were no differences between paraffin-processed and fresh-frozen materials in detectability of ABH antigens. Comparing specimens at operation with those at autopsy from the same patient, the loss of A and B antigens in the latter was demonstrated more frequently than H antigen. Concerning the relation between the prognoses and the expression of ABH antigens, the group with good prognosis preserved more ABH antigens than that with poor prognosis. In contrast, the group with poor prognosis showed less ABH antigens. There were also statistical differences in antigen detectability and prognosis, particularly in stage 1 patients, adenocarcinomas and well-differentiated lung cancers.

ABO Blood-Group System↗