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Biomedical subjects

S Kanoh

Publications and source records attributed to S Kanoh.

At least 109 records · Page 6Linked to original sources
PubMed1983

[A case of amyloidosis of the ureter].

This is a case report of a localized amyloidosis of the ureter presented with gross hematuria. Amyloidosis of the ureter is a rare entity and 21 cases have been collected from the Japanese and English literature. It is believed to be difficult to diagnose before surgery and almost all the cases were treated by nephrectomy. After malignancy was denied, autotransplantation combined with psoas hitch procedure was carried out in order to preserve the kidney. This is the second case of ureter amyloidosis treated by autotransplantation. Amyloidosis was confirmed with Congo red stain and electronmicroscopy of which characteristics is discussed in detail.

Amyloidosis↗
PubMed1983

Establishment of a cell line (TSUS-1) derived from a human squamous cell carcinoma of the penis.

We established a cell line ( TSUS -1) derived from a relatively well-differentiated squamous cell carcinoma of the penis. The cells had been subcultured 60 times during two years and five months. The average doubling time of this cell line was 38 hours. Chromosomal analysis indicated that the modal chromosome number was 75; seven marker chromosomes and a male karyotype were present. The cultured cells were easily transplantable into BALB/c nude mice and the histological picture of the inoculated tumor was similar to that of the original tumor.

Adult↗
PubMed1983

[Studies on the pharmacological bases of fetal toxicity of drugs. III. Fetal toxicity of potassium nitrate in 2 generations of rats].

The fetal toxicity of potassium nitrate (KNO3) used widely as a food additive was studied in Wistar rats. The pregnant rats were fed a diet containing 2.5, 0.5 or 0.1% of KNO3 from day 7 to 14 of pregnancy. Neither maternal nor fetal toxicity including external malformations were observed at term in any group. After spontaneous delivery, the offspring were reared until 13 weeks after birth. No harmful effects were detected in any group. The female offspring (F1) of all groups were mated with the male (F1) of the same group. Good reproductive performances were shown in all groups. The pregnant rats were fed the same diet, which their mothers (F0) had been fed, from day 7 to 14 of pregnancy. Various types of malformations such as exencephaly, cleft lip and palate, polydactyly and micro- or anophthalmia were observed in 6 of 133 fetuses and 7 of 63 newborns from dams treated with 2.5% KNO3, but no external malformations were observed in other groups. The male offspring (F2) of the treated groups showed slow growth until 13 weeks after birth. These results suggest that a dose of 2.5% KNO3 is toxic to the F2 generation, but not to the F1 generation.

Abnormalities, Drug-Induced↗
PubMed1983

Renal cell carcinoma in a solitary kidney treated by partial nephrectomy--case report and review of Japanese literature.

Renal cell carcinoma in a solitary kidney is rather rare. We present a case of this condition occurring in a 50-year-old man. He was treated by partial nephrectomy and temporary hemodialysis for postoperative acute renal failure. Perusal of the literature reveals that in situ partial nephrectomy, if possible, seems to be a reasonable treatment of choice for renal cell carcinoma in a solitary kidney. This is the fifth case ever reported in Japan.

Acute Kidney Injury↗
PubMed1983

A case of amelanotic malignant melanoma of the female urethra.

We report a case of amelanotic malignant melanoma of the female urethra. The clinical course was unusually long and complicated by asynchronous resectable metastases to the lung and the brain. The patient died of generalized metastasis in spite of successful resection of the metastatic lesions and post-operative chemotherapy, two years and five months after the first presentation. To the best of our knowledge this is the second reported case of amelanotic melanoma in the female urethra.

Female↗
PubMed1982

Renal autotransplantation for localized amyloidosis of the ureter.

Localized amyloidosis of the ureter is a relatively rare disease, causing at times ureteral stenosis with hydronephrosis and renal function impairment to various extent. Although it is not malignant nearly all reported cases have been treated by nephroureterectomy because it is clinically difficult to differentiate this entity from ureteral malignancy. We report a case in which the ipsilateral kidney was salvaged successfully by renal autotransplantation. To the best of our knowledge, this is the first case reported of renal autotransplantation for localized amyloidosis of the ureter in the English literature. We suggest that renal autotransplantation be considered in cases of localized ureteral amyloidosis.

Amyloidosis↗
PubMed1982

Xanthogranulomatous pyelonephritis in childhood: case report and review of English and Japanese literature.

Xanthogranulomatous pyelonephritis is an uncommon disease that is usually seen in middle-aged women and is much rarer in children. We report a case of diffuse xanthogranulomatous pyelonephritis in a 3-year-old boy who had a nonfunctioning hydronephrotic right kidney on an excretory urogram. A review of the English and Japanese literature on xanthogranulomatous pyelonephritis in childhood revealed 2 remarkable differences regarding the incidence of sex and radiological findings. The majority of patients were girls in the English literature, whereas the opposite sex was seen in the majority of cases in Japan. The involved kidney was functioning on an excretory urogram in the majority of cases reported in the English literature, however, in all cases from Japan the involved kidney was non functioning. These findings further support the newer concept that xanthogranulomatous pyelonephritis in childhood exists in focal as well as diffuse forms.

Child, Preschool↗
PubMed1982

Interactions between bacterial pyrogen and proteolipid extracted from the cerebrum. (III). Variation in affinity of proteolipid proteins derived from rabbit, rat and chicken cerebrums to bacterial pyrogen.

We undertook comparative studies on the binding of cerebral proteolipids to LPS using rabbits, rats and chickens in order to clarify the differences in inactivating effects of proteolipids from these three sources on the pyrogenicity of LPS. The Sephadex LH-20 column elution profiles of lipid phosphorus and cerebrosides were not significantly different for the three sources of proteolipid, but a larger amount of proteolipid-protein possessing LPS pyrogenicity inactivating potency was eluted with chloroform (C)/methanol(M) (4:1) in rats and chickens than in rabbits. A complex of proteolipid-protein with LPS was obtained in C effluent from incubation mixtures of rat and chicken proteolipids with LPS, corresponding to our previous observation with rabbit proteolipid. The increasing order of binding capacity of the proteolipids derived from the three species was as follows: chicken, rat and rabbit, which was in parallel with pyrogenic inactivating potency. From these data, we suggest that the difference in pyrogenic inactivating potency among the proteolipids of some species depends on the difference in binding capacity of the proteolipids to LPS or probably lipid A.

Animals↗
PubMed1982

Studies on chronic toxicity of the low levels of O, O-dimethyl O-(3-methyl-4-nitrophenyl) phosphorothionate (sumithion) in the rat.

To observe the chronic toxicity of Sumithion (o, o-dimethyl, o-(3-methyl-4-nitrophenyl) phosphorothionate), 8 groups of male and female rats were fed for one year with control food and food containing 1, 5 and 25 ppm of the compound. Acute toxicity was also done. We obtained the following results; 1. Oral an intraperitoneal LD50 of male rats were 250 and 500 mg/kg and those of female rats were 310 and 500 mg/kg respectively. All rats showed neurotropic symptoms according to dose. 2. There was no significant difference in body weights, food and water intakes for one year experiment at those dose levels. Some pneumonitis was observed by histological findings in experimental groups at the end of the experiment. 4. Acetylcholinesterase activity of brain, liver and red blood cells slightly decreased in the first month after feeding, but it recovered and kept normal level unit the end of experiment.

Acetylcholinesterase↗
PubMed1982

[Studies on the pharmacological bases of fetal toxicity of drugs. (I). Relation of fetal toxicity and tissue concentration of acetylsalicylic acid with pyrogen in pregnant rats].

The mechanism for the enhancing effect of pyrogen (lipopolysaccharide, LPS) on the fetal toxicity of acetylsalicylic acid (ASA) was studied in pregnant rats. The lethality of ASA was significantly enhanced by LPS in male rats. The fetal toxicity of ASA including fetal death, resorption, growth retardation, and skeletal anomalies (wavy rib and asymmetry of sternebra) was slightly observed in the dams that received a single dose of ASA (125 to 500 mg/kg, p.o.) on the 15th day of gestation, but it was markedly increased by LPS (20 micrograms/kg, i.v.). The enhancement of the toxicity of ASA by LPS was also observed in the maternal body weight gain until term. The plasma concentrations of ASA and salicylic acid (SA), the major metabolite of ASA, were increased by LPS. The tissue concentrations of SA were also increased in the following order: placenta, brain, fetus, uterus, liver and kidney. The ATP levels of placenta and fetus were not influenced by ASA alone, but markedly decreased by both LPS and ASA.

Abnormalities, Drug-Induced↗
PubMed1982

[Studies on the pharmacological bases of fetal toxicity of drugs. (II). Effect of trypan blue on the pregnant rats and their offspring].

We performed studies on the mechanisms for the teratogenicity of trypan blue (TB) that is known as a potent teratogenic dye in rodents. TB was administered to Wistar rats at various doses and at different stages of gestation. Teratogenicity and embryolethality were observed by a single (50 and 250 mg/kg) subcutaneous injection and three (25 and 50 mg/kg) subcutaneous injections of TB daily from day 7 of pregnancy. The incidences of malformations in groups given 50 and 250 mg/kg on day 7 were 12 and 59%, respectively. Most of the fetuses with external malformations were accompanied with skeletal and/or internal anomalies. The types of frequently occurring malformations were as follows: exencephaly, spina bifida, tail anomaly, vertebral deformity, hydrocephaly and heart anomaly. Fetal toxicity was decreased after treatment with the mixture of TB and normal rat serum. The serum level of TB in pregnant rats increased to 308 micrograms/ml at one hour after subcutaneous treatment with TB 50 mg/kg and decreased rapidly, but remained at 58 micrograms/ml 72 hours later. Lower serum levels of TB were observed in pregnant rats given TB with serum. No fetotoxic effects of serum from pregnant rats treated with TB were observed in recipient rats given the serum on day 7, 8 and 9 of pregnancy.

Abnormalities, Drug-Induced↗