Biomedical subjects
Publications and source records attributed to S Kaji.
A young man had hereditary sensory radicular neuropathy with relapsing ulcer of the foot and, in addition to previously known clinical features, osteoarthropathy with hallux valgus, metatarsus primus varus, exostosis, and pes planus.
A mass screening for prostatic cancer was conducted in Hisayama town, Fukuoka Prefecture, Japan from 1988 to 1989. As the primary screening questionnaire survey about urination and measurement of serum prostate specific antigen (PSA) were performed in 789 of the 1025 male residents over 50 years old (77.0%). For the second screening with digital rectal examination and transrectal ultrasonography, 184 subjects (23.3%) were picked up. Prostatic cancer was suspected in 33 (4.2%) of the 134 subjects who actually underwent the second screening examination. Prostatic biopsy and other examinations such as measurement of prostatic acid phosphatase and gamma-seminoprotein, urinalysis and radiographic examination were performed in 26 as the third screening, and prostatic cancer was detected in 5 (0.63%); 3 in stage B and 2 in stage C. Four of the 5 subjects with prostatic cancer had complained no urinary symptoms on questionnaire. Serum PSA was useful for detecting early stage prostatic cancer.
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In an open trial the antiepileptic effects of flunarizine were studied in 64 patients with intractable epilepsy, and the following results were obtained: 1. Seizures disappeared completely in 2 cases, with a 50% decrease in 6 cases. 2. Of the 25 patients who had accompanying psychiatric symptoms 8.0% showed an improvement in these symptoms. 3. While no marked side-effects were observed, some cases showed an increase in frequency of seizures and the trial was stopped for 8 cases. 4. "Global evaluation" showed an overall improvement rate of 9.4%. In 47 cases, in which changes in frequency of seizure were confirmed and dosage of flunarizine was subsequently changed, improvement rate was 12.8%. 5. The above results suggest that the effectiveness of flunarizine in this open trial was very low.
Single neurons were recorded in the inferotemporal cortex (IT) of a monkey trained to discriminate three selected human faces from a large number of different faces. Neurons which were not responsive to non-face visual stimuli used in the task but were responsive to certain sets of faces were found in the gyrus of the IT. The correlation analysis between the quantified facial features and the responses has revealed that face neurons detect the combination of the distances between facial parts such as eyes, mouth, eyebrows, hair, and so on. One of the face neurons detected the combination of the degree that the forehead above the left eye covered with hair and the distance between the eyes and the mouth. The results of this analysis have given appropriate reason for naming the neurons as the face neurons.
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A case of leiomyosarcoma of the scrotum in a 47-year-old man is presented. A review of the English literature revealed this to be the 7th reported case of leiomyosarcoma of the scrotum, and sufficiently wide surgical excision is required as the initial treatment.
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An examination was made of the responses of complex cells in cat's striate cortex to a textured (nonoriented) stimulus moving in the preferred direction, superimposed upon either a textured or a grating stimulus (oriented) that was moved in different directions. The cell discharges elicited by the textured stimulus moving in the preferred direction were reduced by the textured stimulus moving in nonpreferred directions, and increased when moved in the preferred direction. A grating moving in nonpreferred directions showed similar inhibitory effects on the responses to a textured stimulus moving in the preferred direction. Neural processing for directional movement is, therefore, affected by other neural processing for directional movement, and still more by that for orientation.
The responses of the cat's visual cortical cells to an optimally oriented (O-) and an inclined (theta-) slit have been studied. Cell's responses to the simultaneous presentation, in simple cells, are similar to those to theta-slit alone, but in complex cells, are remarkably decreased at orientation difference of about 45 degrees. In the sequential presentation, the effects of preceding theta-slit on the responses to the following O-slit decrease as the orientation difference increases. This suggests that neural interactions of simultaneous and sequential presentation of two slits are caused by different mechanisms.
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