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Biomedical subjects

S K Wilson

Publications and source records attributed to S K Wilson.

66 records · Page 4Linked to original sources
PubMed1971

Immunofluorescent evidence for cellular control of synthesis of variable regions of light and heavy chains of immunoglobulins G and M by the same gene.

Two distinct paraproteins (IgG(2)-K and IgM-K) from one patient shared identical light chains and significant portions of the variable regions of the heavy chains. Idiotypic determinants on the IgG and IgM molecules were shared. Earlier studies, using class-specific antisera, showed that these paraproteins were produced by two different populations of cells. The present study, using rhodamine and fluorescein conjugates of the anti-idiotype antisera, demonstrates that all plasma cells that contain immunoglobulin, whether IgG or IgM, stained with anti-idiotype antisera; this occurred irrespective of whether the antisera were made originally against the patient's IgG or IgM. This, plus previous data, indicates that both populations of cells share genetic information for the constant and variable regions of light chains and significant portions of the heavy-chain genes. These, and other cited data, strongly suggest the occurrence of a switch-over from IgM to IgG synthesis in the same cell during the course of the normal immune response.

Animals↗
PubMedDate not supplied

Human tissue research in the genomic era of medicine: balancing individual and societal interests.

Advances in DNA sequencing technology and in our understanding of the human genome are ushering in a new era of genomic medicine, one with dramatic potential to not only benefit society through research involving human tissue, but also to cause economic or psychosocial harms to tissue donors and their families. This delicate situation requires that the needs of tissue donors be carefully considered and balanced with those of the medical research community, especially on issues concerning confidentiality, consent, and compensation. We analyzed the tensions between tissue donors and researchers over the research use of human tissue. We also reviewed several approaches, including the establishment of tissue-trustee infrastructures at academic medical centers, aimed at achieving a more equitable balance between individual donor protection and societal benefits derived from tissue-based research. Arch Intern Med. 2000;160:3377-3384.

Academic Medical Centers↗
PubMedDate not supplied

Multi-institutional outcome study on the efficacy of closed-suction drainage of the scrotum in three-piece inflatable penile prosthesis surgery.

Infection is a devastating complication of penile prosthesis surgery that occurs in approximately 2-5% of all primary inflatable penile primary implants in most series. Prevention of hematoma and swelling with closed-suction drains has been shown not to increase infection rate and yield an earlier recovery time. Despite the intuitive advantages of short-term closed-suction drainage in reducing the incidence of postoperative scrotal swelling and associated adverse effects, many urologists are reluctant to drain the scrotum because of a theoretical risk of introducing an infection. In conclusion, this study was undertaken to evaluate the incidence of infection in three-piece penile prosthesis surgery with scrotal closed-suction drainage. A retrospective review of 425 consecutive primary three-piece penile prosthesis implantations was performed at three institutions in New Jersey, Ohio, and Arkansas from 1998 to 2002. Following the prosthesis insertion, 10 French Round Blake (Johnson & Johnson) or, in a few cases, 10 French Jackson Pratt, closed-suction drains were placed in each patient for less than 24 h. All subjects received standard perioperative antibiotic coverage. Average age at implant was 62 y (range 24-92 y). Operative time (incision to skin closure) was less than 60 min in the vast majority of cases. There were a total of 14 (3.3%) infections and three hematomas (0.7%) during an average 18-month follow-up period. In conclusion, this investigation revealed that closed-suction drainage of the scrotum for approximately 12-24 h following three-piece inflatable penile prosthesis surgery does not result in increased infection rate and is associated with a very low incidence of postoperative hematoma formation, swelling, and ecchymosis.

Adult↗