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Biomedical subjects

S K Verma

Publications and source records attributed to S K Verma.

At least 19 recordsLinked to original sources
PubMed1999

Random amplified polymorphic DNA analysis of Indian scented basmati rice (Oryza sativa L.) germplasm for identification of variability and duplicate accessions, if any.

Genetic variation among the seventeen basmati rice accessions collected from the farmers' fields located at different places in India was analyzed using ten arbitrary tenmer oligonucleotide primers by the random amplified polymorphic DNA (RAPD) method. The number of polymorphic/monomorphic bands among the pairwise combinations of the accessions and the total number of bands were determined to categorize all the accessions in different groups of similarity and dissimilarity at the genetic level. The procedure described also allows the identification and discrimination of the individual genotypes of basmati rice including the identification of the duplicates in genetic resource collections.

DNA, Plant↗
PubMed1999

Accidental hanging with delayed death in a lift.

While hanging is a common method of committing suicide in India, accidental hanging is uncommon. However, it does occur when people are engaged in auto-erotic practices. An adult male who was helping passengers trapped in the lift of an outpatient department at a teaching hospital was accidentally hanged. He survived for 39 days. This case highlights a rare but serious hazard in the use of lifts.

Accidents, Occupational↗
PubMed1999

Primary progressive aphasia : a case report.

Primary progressive aphasia is due to focal left perisylvian degeneration and manifests with progressive decline in language function for two or more years. There is preservation of cognitive functions and activities of daily living continue to be normal. We report a case of progressive aphasia in a 65 year old lady.

Aged↗
PubMed1999

Immunological assessment of infertility by estimation of antisperm antibodies in infertile couples.

160 clinical samples were collected from 40 infertile couples with unexplained infertility. The samples collected included serum and seminal plasma of the male partners and serum and cervical mucus samples of the female partners. 25 fertile healthy couples were investigated as controls. All the samples collected were then tested for class-specific antisperm antibodies by an Enzyme linked immunosorbent assay (ELISA). Antisperm antibodies were detected in 30% of the infertile couples which included 25% female and 10% male partners. Amongst the cases positive for antisperm antibodies, antibodies were detected most frequently in female sera 58.4% followed by male sera 33% and 25% in cervical mucus. The isotyping of antisperm antibodies in various samples showed IgG to be the most frequent type specific antibody followed by IgM & IgA types of antibodies. ELISA has provided a relatively simple, reliable and highly reproducible method of detection of antisperm antibodies. Thus application of antisperm antibody testing especially in cervical mucus should become an integral part of the investigation of immunologic infertility.

Adult↗
PubMed1998

Sudden death in neurocysticercosis by trauma.

Neurocysticercosis (NCC) is the commonest parasitic infection affecting the central nervous system in the world. However, sudden death is rare in these cases. Increased intracranial pressure, hydrocephalus, acute encephalitis, meningitis and reaction to antilarval drugs are the common causes of death in NCC. The case reported here is a rare case of sudden death, in an apparently healthy asymptomatic young adult male, who met with a vehicular accident and died almost instantaneously due to ruptured cysts of cysticerci produced by trauma. Possible mode of death is also discussed.

Accidents, Traffic↗
PubMed1998

Effect of garlic (Allium sativum) on blood lipids, blood sugar, fibrinogen and fibrinolytic activity in patients with coronary artery disease.

Thirty patients with coronary artery disease (CAD) were administered garlic (study group) while another 30 patients received the placebo (control group). Various risk parameters were determined at 1.5 and 3 months of garlic administration. Garlic, administered in a daily dose of 2 x 2 capsules (each capsule containing ethyl acetate extract from 1 g peeled and crushed raw garlic), reduced significantly total serum cholesterol and triglycerides, and increased significantly HDL-cholesterol and fibrinolytic activity. There was no effect on the fibrinogen and glucose levels. In vitro effects of the garlic oil on platelet aggregation (PAg) and eicosanoid metabolism were examined; it inhibited PAg induced by several platelet agonists, and also platelet thromboxane formation. Two important paraffinic polysulphides - diallyl disulphide (DADS) and diallyl trisulphide (DATS) - derived from garlic and are usual constituents of garlic oil, showed antiplatelet activity, and also inhibited platelet thromboxane formation. In this respect DATS was more potent than DADS. The nature of inhibition of PAg by DATS was found to be reversible.

Allyl Compounds↗
PubMed1998

Quality of life in schizophrenia and dysthymia.

Quality of life (QOL) was assessed in three groups of patients, consisting of 30 schizophrenic patients with duration of illness <2 years, 30 schizophrenic patients with duration of illness > or = 2 years and 30 dysthymic patients. The diagnoses were made according to ICD-10. Two scales of quality of life were used, one of which was specific for schizophrenia, while the other was generic for all patients. On inter-group comparison the two schizophrenia groups did not show significant differences in quality of life, but on comparing schizophrenic and dysthymic patients, significant differences emerged. Dysthymic patients were significantly less satisfied than schizophrenic patients with duration of illness <2 years in the domain of physical health. In the domains of satisfaction with medication and leisure-time activities, both schizophrenic groups were significantly more satisfied than the dysthymic group. Comparison of the quality of life ratings of our patients with those of a well-known study from Sweden revealed some significant differences which relate to the domains of work, contacts, inner experience and leisure-time activities. Cultural factors are invoked to account for these differences. The need for refinement of assessment of quality of life in multi-racial and multi-ethnic contexts is stressed.

Activities of Daily Living↗
PubMed1998

Antioxidant property of Saffron in man.

50 mg of Saffron dissolved in 100 ml of milk was administered twice a day to 20 human subjects. Lipoprotein oxidation susceptibility (LOS) was estimated initially and after 3 and 6 weeks. There was a constant decrease in LOS during this period. From a mean of 66.4 +/- 3.18 it decreased to 38.3 +/- 2.8 in 10 healthy individuals and from 76.0 +/- 3.72 to 48.8 +/- 3.0 in 10 patients of CAD. The significant fall (P < 0.001) in LOS indicates the potential of Saffron as an antioxidant.

Antioxidants↗
PubMed1997

Effect of ginger (Zingiber officinale Rosc.) and fenugreek (Trigonella foenumgraecum L.) on blood lipids, blood sugar and platelet aggregation in patients with coronary artery disease.

In a placebo-controlled study the effect of ginger and fenugreek was examined on blood lipids, blood sugar, platelet aggregation, fibrinogen and fibrinolytic activity. The subjects included in this study were healthy individuals, patients with coronary artery disease (CAD), and patients with non-insulin-dependent diabetes mellitus (NIDDM) who either had CAD or were without CAD. In patients with CAD powdered ginger administered in a dose of 4 g daily for 3 months did not affect ADP- and epinephrine-induced platelet aggregation. Also, no change in the fibrinolytic activity and fibrinogen level was observed. However, a single dose of 10 g powdered ginger administered to CAD patients produced a significant reduction in platelet aggregation induced by the two agonists. Ginger did not affect the blood lipids and blood sugar. Fenugreek given in a dose of 2.5 g twice daily for 3 months to healthy individuals did not affect the blood lipids and blood sugar (fasting and post prandial). However, administered in the same daily dose for the same duration to CAD patients also with NIDDM, fenugreek decreased significantly the blood lipids (total cholesterol and triglycerides) without affecting the HDL-c. When administered in the same daily dose to NIDDM (non-CAD) patients (mild cases), fenugreek reduced significantly the blood sugar (fasting and post prandial). In severe NIDDM cases, blood sugar (both fasting and post prandial) was only slightly reduced. The changes were not significant. Fenugreek administration did not affect platelet aggregation, fibrinolytic activity and fibrinogen.

Arachidonic Acids↗
PubMed1997

Life events preceding relapse of schizophrenia.

In this study, retrospective assessment of life events over a period of one year was carried out in two groups of schizophrenic patients. Each group had 30 patients. One group comprised "relapsing" schizophrenics and the other consisted of "stable" patients. The group of "relapsing" schizophrenics had experienced a significantly greater number of life events and also had a significantly higher stress score than the "stable" group. However, analysis of the distribution of life events over the study period of one year showed no increase in the frequency of occurrence of life events in the three months prior to relapse. Similarly, no such significant increase in the stress score was seen in the same period of time in the group which had relapsed. Treatment compliance and stress scores accounted for nearly 40% of the variance of the data in the "relapsing" group. Implications of the findings are highlighted.

Humans↗
PubMed1996

Accidental strangulation in a rickshaw.

A 40-year-old female was accidentally strangulated by a 'Chunni' (piece of cloth worn around neck) while travelling in a cycle rickshaw. She was declared dead on arrival in the hospital. This case highlights the hazards of wearing cloth loosely around the neck while travelling in a rickshaw which is a common mode of transport for short distances in India and other South-East Asian countries.

Accidents↗
PubMed1996

Effect of garlic on platelet aggregation in humans: a study in healthy subjects and patients with coronary artery disease.

Garlic's value in preventing cardiovascular disease has been reported by several research groups. Garlic and its components are known to possess antiplatelet activity which has been demonstrated mostly in vitro. It was found that garlic oil administration to healthy subjects and patients with coronary artery disease (CAD) inhibited platelet aggregation ex vivo. Though garlic components leave the body quickly, a slow build-up of the active ingredients may take place. This was evident from the observation that though a 2-3 fold higher dose was not effective in inhibiting platelet aggregation when administered once, a lower dose became effective in long-term administration.

Adult↗