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Biomedical subjects

S K Satpathy

Publications and source records attributed to S K Satpathy.

32 records · Page 2Linked to original sources
PubMed1990

Epidemiological study of measles in Singur, West Bengal.

A measles survey in 10 villages of Rural Health Unit and Training Centre, Singur revealed 581 cases of measles from January to June 1986. The overall attack rate was 40/1000. The highest attack rate (43.5 per cent) was observed in the age group of 1-2 years followed by 6-8 months age group. 11.5 per cent of the cases were below the age of 9 months and 10.4 per cent cases were above the age of 15 years. 42.3 per cent of cases developed one or the other complications. Diarrhoea and respiratory infections were the two common complications. Case fatality rate was only 0.17 per cent. Epidemiological aspects of these observations are discussed.

Adolescent↗
PubMed1989

Hepatic morphology in reactional states of leprosy.

Liver function tests and liver biopsies were studied in 23 leprosy patients in reaction and 10 without reaction. The liver biopsies in leprosy patients with reaction showed exudative lesions, epithelioid and tuberculoid granulomas, and foam-cell granulomas. Portal vasculitis was encountered in a few cases. Neutrophilic infiltration into the foam-cell granulomas was seen in a few cases of lepromatous (LL) leprosy with reaction. In six cases of borderline (BL, BB and BT) leprosy with reaction, a spectrum of lesions bearing footprints of exudative lesions were seen evolving into epithelioid-cell granulomas. Foam-cell granulomas and tuberculoid and epithelioid granulomas along with exudative lesions were encountered in two cases on individual biopsy strips. An altered albumin-to-globulin ratio was the chief functional derangement observed in these cases. The spectrum of changes observed in borderline leprosy with reaction could be discrete steps in the evolution of upgrading reaction.

Adolescent↗
PubMed1988

Hypoglycaemia in severe falciparum malaria.

The incidence of hypoglycaemia and the role of quinine in its causation was assessed in 46 patients with severe Plasmodium falciparum malaria. Plasma glucose and immunoreactive insulin were estimated before, during and after quinine therapy. In 5 patients the plasma glucose was in the hypoglycaemic range, the lowest value being 0.67 mmol/litre (12 mg/dl) in a pregnant patient. Most of the remaining patients showed a significant fall in plasma glucose (P less than 0.05), but not to the hypoglycaemic range, and an increase in plasma insulin after quinine (P less than 0.01). A good correlation was found between these changes (r = 0.79, P less than 0.01). Patients with severe P. falciparum malaria, particularly those on quinine therapy, should be watched carefully for developing hypoglycaemia.

Adolescent↗
PubMed1982

Prevalence of paralytic poliomyelitis in Pondicherry, South India.

A community health survey conducted in 16 villages of three blocks of Union Territory of Pondicherry detected lame children affected by poliomyelitis among other problems identified. The survey was conducted from July 1980 to September 1981. The survey method was house-to-house, covering 97% of the houses in the study area. Prevalence of lameness due to poliomyelitis among children aged from 6 to 15 years was 1.6 per thousand. These results were compared with those of the school health survey conducted by the School Health Education Bureau, Pondicherry, for the year 1980-1, which gave an estimate of 0.7 per thousand. The community health examination also confirmed that most of those affected were under 15 and that boys were more vulnerable than girls, as reported by other workers.

Adolescent↗
PubMedDate not supplied

Increased cerebrospinal fluid protein and lipid peroxidation products in patients with cerebral malaria.

Membrane lipid peroxidation by reactive oxygen species leading to increased capillary permeability is considered an important event in the pathogenesis of severe malaria. A significant decrease in plasma albumin and increases in cerebrospinal fluid (CSF) protein and malondialdehyde (MDA) were observed in 73 patients with cerebral malaria, compared to values in 23 control patients. The greatest effect was noticed in the most severely ill patients. The ratio of CSF protein to plasma albumin was increased in the patients compared to the controls, and in fatal cases of cerebral malaria compared to non-fatal cases. Brain necropsies showed oedema, fibrin deposits and mononuclear cell infiltration. It is proposed that cerebral oedema due to enhanced permeability of vascular endothelium induced by increased lipid peroxidation plays a crucial role in the causation of cerebral malaria.

Capillary Permeability↗
PubMedDate not supplied

Effectiveness of alpha,beta-arteether in acute falciparum malaria.

With the emergence of widespread chloroquine resistance and a world-wide scarcity of quinine, a search for newer antimalarial drugs has become imperative. Different derivatives of qinghaosu have been successfully tried. alpha,beta-Arteether, an ethyl derivative of qinghaosu, was administered to 51 patients with Plasmodium falciparum malaria, in a dose of 150 mg intramuscularly once a day on 3 consecutive days. Complete parasite clearance from the peripheral blood was observed in 80% of the patients at 48 h and in 98% at 72 h. The median parasite clearance time was 2 d (range 1-4 d). 65% of the patients became afebrile within 48 h and 81% by 72 h. The mean fever clearance time was 52.04 h (standard deviation 27.09). No side effect was seen. Patients were followed-up for 4 weeks; 7 were readmitted with P. falciparum infection but it could not be ascertained definitely whether these cases were reinfections or recrudescences. alpha-beta Arteether was a safe, effective and convenient drug for treating P. falciparum malaria. This is the first clinical study with arteether in falciparum malaria.

Adolescent↗
PubMedDate not supplied

alpha, beta-Arteether for the treatment of complicated falciparum malaria.

alpha, beta-Arteether is an ethyl ether derivative of artemisinin which is an efficient schizontocidal drug in mild falciparum malaria. The present study reports the efficacy of the drug in severe falciparum malaria. Fifty patients with severe falciparum malaria were given intramuscular arteether, 150 mg, once daily on 3 consecutive days. The median fever clearance time was 72 h (range 12-120 h) and the median parasite clearance time was 2 d (range 1-4 d). Rapid recovery from coma was observed in cerebral malaria patients (after a median of 18 h, range 6-72 h). The recovery from other complications was also faster and complete. Two patients died; both had cerebral malaria and haemolytic jaundice, one had respiratory distress needing ventilatory support and the other had severe anaemia. Recrudescence within 28 d was observed in 7 patients. Drug toxicity or significant side effects were not noticed in any patient.

Antimalarials↗
PubMedDate not supplied

Health economics--concepts and conceptual problems.

Awareness of the economic manifestation of health and diseases and the limited resources allocated to health care services has brought to the focus a new discipline - health economics. Cost accounting, cost benefit, cost effectiveness methods etc. are increasingly becoming an integral part of the health management and evaluation of health programmes. Various concepts and problems relating to health economics are discussed in the present paper. More efforts should be made to conduct health economic studies in hospitals and health centres by which the process of standardisation of the concepts, would be easier. Health economics should also find its due place in the medical curriculum.

Cost-Benefit Analysis↗
PubMedDate not supplied

Indian public health standards (IPHS) for community health centres.

The health care system in India has expanded considerably over the last few decades but the quality of the services is not up to the mark due to various reasons. Hence standards are being introduced in order to improve the quality of services. A task group under the chairmanship of Director General of Health Services, Government of India was constituted to recommend the standards to be called as Indian Public Health Standards. IPHS are a set of standards envisaged to improve the quality of health care delivery in the country under the National Rural Health Mission.

Community Health Centers↗