Search PubMed⌕ Search

Biomedical subjects

S K Gupta

Publications and source records attributed to S K Gupta.

At least 757 records · Page 42Linked to original sources
PubMed1984

System for widespread application of microcomputers to vascular surgery.

The application of microcomputers to vascular surgery has been limited because of the lack of software that allows collection and effective evaluation of a large amount of patient-related data. We have developed a microcomputer-based data handling system for evaluating vascular patients that is inexpensive ($6000 to $8000), easy to use, and flexible. Its simplicity for nonprogrammers is achieved through a natural interface with menu-driven operations and descriptive English language messages. With this system eight data entry forms were designed, and data on more than 1000 patients treated for peripheral vascular disease over the last 7 years were entered into the computer by clerical personnel with minimal training. A query language report generator allowed us to obtain reports of results in simple English on any set of selection criteria with all relevant statistical functions, including cumulative life-table patency rates. This system has the following advantages: rapid evaluation of data from several retrospective and prospective studies, such as comparison of graft material, effect of local and systemic risk factors, cost of limb-salvage surgery, and correlation of noninvasive laboratory tests with other parameters; more accurate patient follow-up, with elimination of many of the pitfalls involved in observing large groups of patients frequently; and quantitation of individual surgeon or service results for quality control and self-review, which guide the vascular surgeon to modify treatment protocols, patient selection, and/or surgical techniques. Wider use of this system for data collection and evaluation will help to standardize data reporting and thus allow accurate comparison of data from different centers.

Computers↗
PubMed1984

Mitogenic action of estrogen on thyroid gland of male domestic duckling.

Intramuscular administration of estradiol dipropionate (OVOCYCLIN: CIBA, India) with a daily dosage of 1 mg per bird for 10 days, to male domestic ducklings, induced mitosis in the thyroid gland. Concomitantly, it decreased follicular epithelial height and increased colloidal material in the follicles. It is suggested that estradiol appears to have a dual action on the thyroid gland of the male duckling, since it accelerates mitosis but inhibits thyro-follicular activity of these birds.

Animals↗
PubMed1984

Staging of arterial complications of cervical rib: guidelines for surgical management.

Subclavian artery compression by a cervical rib is an uncommon but potentially disabling condition. A series of 12 patients with 15 arterial lesions is reviewed and a staging system proposed to provide guidelines for managing patients with this condition. Stage I lesions have only arterial stenosis and minor poststenotic dilatation and are managed by thoracic outlet decompression, usually consisting of cervical rib resection. Stage II lesions have intrinsic arterial damage usually with subclavian aneurysm formation and require rib resection, aneurysmectomy, and arterial reconstruction. Stage III lesions present with distal thromboembolic complications and require thrombectomy or embolectomy in addition to thoracic outlet decompression and arterial reconstruction. The anatomic and pathophysiologic bases of the syndrome are reviewed and clinical and angiographic examples of each stage are presented.

Adult↗
PubMed1983

Limb-threatening vascular disease in patients with coincidental malignancy. An approach to management.

The association of severe peripheral arteriosclerotic occlusive disease and cancer is unusual. Review of 14 patients with both conditions treated by arterial reconstruction demonstrated excellent limb salvage without prejudice of survival or patency. Accordingly, we believe that limb salvage operations should be considered in patients with limb-threatening peripheral vascular disease and an associated cancer.

Adult↗
PubMed1983

Macrophage specific antigen is expressed by resting microglia in the CNS but not by Langerhans cells in the skin.

Controversy exists as to whether Langerhans cells in the epidermis and resting microglia in the brain should be included among cells of the mononuclear phagocyte series (MPS). A monoclonal anti-guinea-pig macrophage antibody has been prepared that is specific for a macrophage membrane antigen and does not react with Fc receptors or Ia antigens. This antibody fails to react with Langerhans cells despite reacting with peritoneal exudate macrophages, alveolar macrophages, Kupffer cells and macrophages in infectious granulomas. It does, however, react with resting microglia in the brain. This could suggest that Langerhans cells, despite a similar bone marrow origin, are not typical cells of the MPS, whereas resting microglia share features with this cell system.

Animals↗
PubMed1983

Influence of prolactin on mitotic activity of the bursa of Fabricius of the chick.

The effect of ovine prolactin (NIH-LTH) in different does (1.5, 5.0, 10.0 IU) on the mitotic activity of the bursa of Fabricius of the chick was studied. Prolactin at all doses increased the mitotic activity, but the lowest dosage (1.5 IU) was most effective). Also, prolactin, at all doses, inhibited histologically bursal secretory activity. Thus, dual action of prolactin on bursal activity in chicks is indicated.

Animals↗