Search PubMed⌕ Search

Biomedical subjects

S K Chatterjee

Publications and source records attributed to S K Chatterjee.

At least 91 records · Page 5Linked to original sources
PubMed1981

Studies on glucose-6-phosphatase, fructose-1,6-diphosphatase activity, glycogen distribution and endoplasmic reticulum changes during hexachlorocyclohexane induced hepatocarcinogenesis in pure inbred Swiss mice.

Inbred Swiss mice were fed hexachlorocyclohexane (BHC) at 500 ppm dose level in diet for 2, 4, 6 and 8 months. Later BHC was discontinued for 4 months and subsequently the animals were refed BHC for 1 month. Glucose-6-phosphatase (G6Pase) and fructose-1,6-diphosphatase (FDPase) activity was studied at different time intervals accompanied with changes in glycogen distribution and endoplasmic reticulum (ER) proliferation in hepatocytes. G6Pase and FDPase showed a decline in activities on BHC feeding. The activities of these enzymes showed recovery on BHC discontinuation. The changes were progressive with duration of exposure. After 6 months exposure the biochemical changes became more resistant to recovery. Maximal changes occurred in 8 month-exposure and the changes were irreversible. Glycogen accumulation and depletion followed a definite pattern. After two months of BHC feeding, increase in parenchymal glycogen storage zones was observed. In the later stage of hepatocarcinogenesis and specially in tumors, glycogen was depleted considerably. Smooth endoplasmic reticulum (SER) proliferation was recorded around the 3rd and 4th month. The correlation between glycogen accumulation, SER proliferation, G6Pase and FDPase activity is discussed.

Animals↗
PubMed1980

Determination of serum galactosyltransferase levels in ovarian cancer patients for the evaluation of the effectiveness of therapeutic programs.

The activity of galactosyltransferase using endogenous acceptor(s), (GT-En) in the sera of ovarian cancer patients was significantly higher than age and blood-group matched controls. GT-En, and galactosyltransferase activity using an exogenous acceptor (GT-Ex), were assayed in the sera of 30 patients undergoing treatment for ovarian epithelial cancer, at the start of chemotherapy, and after a suitable interval. The direction of the alterations in levels of both these enzymes correctly reflected the clinical response to chemotherapy in most of these patients. The assay of GT-En and GT-Ex in the serum may be useful for the evaluation of the effectiveness of therapeutic programs in these patients.

Female↗
PubMed1980

Double termination of the alimentary tract--a second look.

This report is based on a series of 21 patients with a relatively rare anorectal malformation. They either had two abnormal tracts leading off from the terminal bowel or otherwise normal bowel coexisting with one abnormal tract or even two abnormal tracts. The anatomy, embryology, and management of the different types are discussed.

Anal Canal↗
PubMed1980

Scar endometriosis: a clinicopathologic study of 17 cases.

Clinicopathologic finding are presented from 17 cases of scar endometriosis studied over a 5-year period. Multiparous women in the third decade of life were most frequently affected. Seventy-one percent of the cases followed abdominal hysterotomy, for a 1.08% incidence of scar endometriosis in the patients who underwent hysterotomy during this period. The most common symptom was painful swelling of the scar which waxed and waned with menses. The majority of patients presented from 1 to 2 years after the precipitating operation. Associated pelvic endometriosis was present in 24% of the patients. Therapy with oral progestogen was ineffective, and the treatment of choice was clearly surgical excision. The causal relationship between surgery and subsequent scar endometriosis is discussed. Methods of prevention are suggested.

Adult↗