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Biomedical subjects

S K BOSE

Publications and source records attributed to S K BOSE.

At least 19 recordsLinked to original sources
PubMed1964

BIOSYNTHESIS OF MYCOBACILLIN, A NEW ANTIFUNGAL PEPTIDE. I. ROLE OF NUCLEIC ACID.

Banerjee, Arun B. (University of Calcutta, Calcutta, India), and S. K. Bose. Biosynthesis of mycobacillin, a new antifungal peptide. I. Role of nucleic acid. J. Bacteriol. 87:1397-1401. 1964.-The biosynthesis of mycobacillin, a cyclic polypeptide antifungal antibiotic, was studied in relation to the effect of chloramphenicol, 6-azathymine, and 5-bromouracil on the process. It was found that chloramphenicol inhibits both mycobacillin synthesis and growth, whereas nucleic acid base analogues inhibit only growth and nucleic acid synthesis but not mycobacillin formation. A change in the concentration of labeled aspartic acid in the general metabolic pool led to a corresponding change in the specific activity of aspartic acid isolated from different peptide fragments of the mycobacillin molecule, suggesting that mycobacillin synthesis occurs by way of linear addition of amino acid to the peptide chain.

Amino Acids↗
PubMed1964

BIOSYNTHESIS OF MYCOBACILLIN, A NEW ANTIFUNGAL PEPTIDE. II. RELATION BETWEEN STREPTOMYCIN DEPENDENCE AND BIOSYNTHESIS.

Banerjee, Arun B. (University of Calcutta, Calcutta, India), and S. K. Bose. Biosynthesis of mycobacillin, a new antifungal peptide. II. Relation between streptomycin dependence and biosynthesis. J. Bacteriol. 87:1402-1405. 1964.-A streptomycin-dependent variant was isolated by a single-step mutation process from a strain of Bacillus subtilis capable of producing mycobacillin, a cyclic polypeptide antifungal antibiotic. Streptomycin inhibited the growth of this variant in concentrations exceeding the optimal level. Studies on the biosynthesis of mycobacillin and protein in this variant indicate that the two processes are different and that the deprivation of streptomycin has no effect on mycobacillin synthesis.

Anti-Bacterial Agents↗
PubMed1963

MODE OF ACTION OF MYCOBACILLIN, A NEW ANTIFUNGAL ANTIBIOTIC.

Banerjee, N. (Calcutta University, Calcutta, India) and S. K. Bose. Mode of action of mycobacillin, a new antifungal antibiotic. J. Bacteriol. 86:387-391. 1963.-Mycobacillin agglutinates cells of Candida albicans. The agglutination reaction was found to be dependent on temperature, pH level, etc. Experiments have also been planned to assess whether agglutination and antifungal action are causally related. It appears that agglutination may be a secondary late effect of the action of the drug, not causally related to but simply associated with the primary cause responsible for antifungal action.

Anti-Bacterial Agents↗