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Biomedical subjects

S Joseph

Publications and source records attributed to S Joseph.

At least 199 records · Page 11Linked to original sources
PubMed1977

Reaginic immune response to tree pollen antigen in LBN rats.

The immunogenicity and cross-antigenicity of ten common tree pollen allergens were studied in LBN rats. The rats produced IgE antibodies to each of the allergens used (maple, willow, poplar, ash, oak, sycamore, hickory, walnut, birch, and elm), yet the allergens had extremely limited cross-reactivity. The possible explanation for the limited cross-antigenicity is discussed.

Animals↗
PubMed1976

Congenital aortic valve disease with rupture of mitral chordae tendineae.

A new clinical entity is described in which free aortic regurgitation from congenital aortic valve disease caused rupture of the chordae to the anterior leaflet of the mitral valve in 7 men aged 45 to 63 years (mean 52 years); 2 of the patients also had rupture of chordae to the posterior leaflet. Comparing these patients with those with ruptured mitral chordae in association with rheumatic heart disease and patients with spontaneous chordal rupture, differences were evident. No patient had a history of rheumatic fever and none had active infection. The typical clinical presentation was of acute mitral regurgitation into a small left atrium, with severe pulmonary oedema which was often resistant to medical treatment. The cause of chordal rupture in these patients was in part the result of progressive left ventricular dilatation, of direct trauma to the anterior cusp of the mitral valve, and possibly of a genetic factor. The anatomical features of both aortic and mitral valves are described, and in 3 histology of the mitral valve was available; 2 had myxomatous degeneration similar to that seen in patients with spontaneous chordal rupture, and in 1 there was degeneration of collagen tissue. All patients were treated surgically but the mortality was high (5 out of 7,70%). Early operation with replacement of the aortic and mitral valves is recommended if this high mortality is to be reduced.

Aortic Valve↗
PubMed1975

Biosynthesis of thyrotropin-releasing hormone in organ cultures of the guinea pig median eminence.

Guinea pig median eminence tissue was put into organ culture for periods up to 13 days. The cultured tissue was examined in 3 ways at various ages: a) morphologically, by transmission electron microscopy and light microscopic autoradiography; b) biochemically, by determination of the ability of the cultures to accumulate [3H]L-proline and to incorporate this isotope into [3H]TRH; and c) by bioassay, in which the content of TRH in tissue and culture medium was determined by the ability of extracts of both to release radioimmunoassayable TSH from rat hemi-pituitaries incubated in vitro. It was found that the cultures exhibited a high degree of preservation of ependymal cell morphology and a sustained ability to accumulate [3H]L-proline over the entire 13-day time course. Neuronal elements showed a progressive degeneration with time in culture, and the ability of the culture to produce [3H]TRH was lost concomitantly with the loss in neuronal integrity.

Animals↗