Methadone maintenance programs.
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Biomedical subjects
Publications and source records attributed to S Jonas.
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Left thalamic lesions can produce motor speech disturbances: disorders of articulation and of phonation. Left thalamic lesions can also produce aphasic disorders: word-emission difficulties; difficulties with comprehension, reading, writing, and arithmetic; and sometimes suppression of conversational propositional speech with preservation of nonpropositional repetitional or automatic speech. The relative preservation of nonpropositional speech justifies the assignment of such cases of thalamic aphasia to the category of transcortical aphasia (TA). Also included in TA are aphasias from dominant hemisphere supplementary motor region (SMR) lesions. In this context the suggestion by Penfield and Roberts that the thalamus and the SMR interact via the pedunculus thalami superior is noted.
This study follows patients with severe sinus bradycardia (40 beats per minute for 6 seconds or greater) in order to evaluate mortality and the effectiveness of permanent pacemaker insertion. Severe sinus bradycardia was noted on a 24-hour Holter in 95 patients. There were 64 males and 31 females with a mean age of 69 +/- 10 years. All were available for follow-up at 26 +/- 13 months. Twenty-eight required a permanent pacemaker at an average of 2 +/- 3 months after the Holter. Of this group 12 had the Holter for arrhythmia, 11 for cerebral symptoms, 4 for palpitations and 1 for chest pain. Only 1 was taking digitalis and no patients were taking Inderal. Six (21%) died at a mean interval of 21 +/- 15 months following pacemaker insertion. Sixty-seven did not require pacemaker insertion. The indications for Holter monitoring were arrhythmia in 16, palpitations in 19, cerebral symptoms in 20 and chest pain in 12. Four of these patients were on digitalis, 8 on Inderal, and 4 on both. Eleven (16%) died at a mean interval of 12 +/- 7 months after the initial Holter recording. Dizziness and/or syncope reoccurred in 22. Five had these symptoms even after pacemaker insertion. We conclude that severe sinus bradycardia is associated with a significant mortality. Insertion of a permanent pacemaker may decrease recurrent symptoms and slightly increase time of survival, but does not appear to influence the overall survival rate.
A 56-year-old man had coronary artery spasm. The initial manifestation of the disease was syncope that occurred at night. Coronary artery spasm was documented by Holter recording and cardiac catheterization. The patient was effectively treated with nitrates and calcium-blocking agents.
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Speech disorders occur with left supplementary motor region (SMR) lesions. Right SMR lesions probably produce speech disorders only when the right cerebral hemisphere is speech-dominant. Paroxysmal SMR dysfunction produces both uncontrollable vocalization and speech arrest. Slowly evolving SMR lesions produce reduced and labored speech output with word-finding difficulties. Suddenly acquired SMR lesions produce marked speech suppression and aphonia; during recovery nonpropositional "automatic" speech may be initiated easily, even involuntarily, while initiation of propositional speech is still difficult or impossible. From the data one can infer that the SMR plays a role in "language" aspects of speech (in word finding, in a mechanism facilitating the emission of propositional over "automatic" speech), and also in the "motor" aspects of speech emission (including rhythm control and the control of phonation and articulation).
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A total of 99 consecutive 24-hour Holter recordings with ventricular tachycardia were reviewed. Ventricular premature beats which occurred alone, and ventricular premature beats which initiated ventricular tachycardia were examined to determine which characteristics correlated with occurrence of ventricular tachycardia and which predicted rate and duration of ventricular tachycardia. The preceding R-R interval, the coupling interval, and a ratio of the two were examined. We found that ventricular tachycardia rate and duration increase with a shorter coupling interval, and the coupling interval/preceding R-R ratio was significantly different in single beats not initiating ventricular tachycardia. The ratio for the beat initiating ventricular tachycardia was smaller, indicating more prematurity.
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The American hospital system has made outstanding contributions to the care of the stick. It now faces the challenge of promoting the concept of "wellness".
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