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Biomedical subjects

S Jonas

Publications and source records attributed to S Jonas.

At least 235 records · Page 13Linked to original sources
PubMedDate not supplied

[Pigeon breeder's disease in childhood].

Pigeon breeder's disease is a common form of hypersensitivity pneumonitis, which is rarely diagnosed in children. We report a seven year old boy, who developed cough, easy fatigue, anorexia and weight loss over a period of two months after having contact with pigeons. The findings on physical examination were tachypnoea and reduced thoracic movements. Chest radiograph showed widespread fine nodular shadowing in both lung fields. Pulmonary function tests demonstrated a restrictive defect and an impaired diffusion. Lymphocytes were highly increased in bronchoalveolar lavage (BAL) fluid. Precipitating antibodies against pigeon excreta was found in the serum. Environmental control of pigeon protein and a course of systemic corticosteroids over 4 months resulted in clinical and lung function improvement. However clinical recovery stopped over several months after discontinuation of steroid therapy. Therefore steroid therapy was reinstalled and continued until complete clinical recovery and pulmonary function occurred, that was 20 months after onset of the disease. Essential for the patient was to avoid further contact with birds. However a prolonged steroid therapy was necessary to achieve complete resolution. Lung function tests were useful for follow up and decisions on further treatment.

Animals↗
PubMedDate not supplied

Effects of human hepatocyte growth factor on the proliferation of human hepatocytes and hepatocellular carcinoma cell lines.

BACKGROUND: Hepatocyte growth factor (HGF) has been suggested to initiate both hepatocyte and tumor cell proliferation after partial hepatectomy, thereby supporting local tumor recurrence. The aim of this study was to clarify the role of HGF in the regeneration of human hepatocyte and the growth of residual hepatocellular carcinoma cells after liver resection. PATIENTS/METHODS: 36 patients who underwent partial hepatectomy for hepatocellular carcinoma (HCC) or living liver donation have been analyzed for HGF serum levels at day -1 through day 5 following surgery using an enzyme-linked immunosorbent assay. Isolated human hepatocytes and HCC cell lines (Hep 3B, Hep G2) were treated either with recombinant human (rh)-HGF, or sera from the 36 patients in the presence or absence of anti-HGF in order to measure their proliferative capacity using (3)H-thymidine incorporation. RESULTS: Basal HGF levels were significantly higher in HCC than in healthy patients (1,573 +/- 131 vs. 778 +/- 64 pg/ml; p < 0.001), however, the postoperative rise of HGF in healthy patients was higher (9,608 +/- 3111 vs. 2,060 +/- 148 pg/ml) than in HCC patients. Incubation of human hepatocytes and Hep 3B cells with rh-HGF revealed a dose-dependent increase in DNA synthesis, while anti-HGF partially abolished this effect. Sera from normal and resected HCC patients stimulated DNA synthesis only in human hepatocytes, whereas it was inhibited in HCC cell lines. CONCLUSION: HGF plays an important role in hepatocyte proliferation but contrary to in vitro results, HGF does not play a major role for the progression of hepatocarcinoma cells in vivo.

Adult↗
PubMedDate not supplied

IMPS (intact months of patient survival): an analysis of the results of carotid endarterectomy.

The literature on carotid surgery for lesions appropriate to prior episodes of ischemia has been reviewed. Only one randomized study and six non-controlled reports give useful data (this despite more than thirty years of surgical activity in this field). When analyzed by the IMPS (intact months of patient survival) criterion, the randomized study failed to show benefit from surgery. This failure can be attributed to a high (35%) operative stroke and death rate. That sufficiently low operative stroke and death rates are readily achievable is not clear, however, only two of six relevant non-controlled series reported in the literature had operative stroke and death rates below the 10.4% level calculated as necessary for a "break-even" situation. Three of the six non-controlled series contain sufficient follow-up data to permit IMPS comparison against the "standard" of the control group of the randomized study. Against this "standard" only one of the three non-controlled studies would have "shown benefit" from surgery. Barnett, Plum, and Walton have called for audits of endarterectomy results in institutions in which such surgery is performed. It is suggested that such audits be done by the IMPS method, which gives appropriate weight to the effects of operative, as well as of long-term follow-up, strokes and deaths.

Carotid Artery Diseases↗