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Biomedical subjects

S Johansen

Publications and source records attributed to S Johansen.

93 records · Page 6Linked to original sources

Effect of the feeding level during rearing on performance of Large White gilts. Part 2: Effect on metabolite profiles during gestation and lactation, and on glucose tolerance.

Eighteen primiparous Large White sows were selected on d 104 of gestation. Animals had either high (AP) or reduced (R) level of body fatness, as a result of different feeding levels during rearing. A jugular catheter was surgically implanted under general anaesthesia and regular blood sampling, glucose tolerance and meal tests were performed. Plasma concentrations of insulin, glucose, urea, non-esterified fatty acids (NEFA), phosphorus and calcium were determined by radio-immune assay or enzymatic assay. Plasma concentration of urea increased with the progress of lactation, whereas NEFA decreased. Results of glucose tolerance and test meals suggested that animals with greater body reserves at farrowing were less tolerant to glucose than the lean ones. In addition, the higher NEFA level observed in AP animals also suggested that the level of body fatness at farrowing might be involved in the regulation of feed intake during lactation and could partially explain the lower spontaneous feed intake observed in these animals.

Adipose Tissue↗

Pharmacokinetic investigation of fusidic acid 1% viscous eye drops in healthy volunteers.

The biological half-life of fusidic acid was measured in tear fluid samples from the inferior fornix of 14 healthy volunteers after instillation of one drop of viscous fusidic acid eye drops. The study comprised four test days separated by six days of wash-out. On the first test day the concentrations of fusidic acid were measured 1 h after installation, on the second test day 3 h after, on the third test day 6 h after, and on the last day 12 h after instillation. The median fusidic acid concentrations in the tear fluid were 15.7 micrograms/ml, 15.2 micrograms/ml, 10.5 micrograms/ml and 5.6 micrograms/ml on the four days. This corresponds to a biological half-life of 7.3 h. Some of the volunteers reported mild local discomfort lasting a few minutes.

Administration, Topical↗