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Biomedical subjects

S Jay

Publications and source records attributed to S Jay.

31 records · Page 2Linked to original sources
PubMed1984

Riboflavin, self-report, and serum norethindrone. Comparison of their use as indicators of adolescent compliance with oral contraceptives.

The purpose of this study was to test the reliability of using the tablet marker, riboflavin, as an indicator of adolescent compliance with oral contraceptives, as compared with self-reports and more costly quantitative determinations of serum norethindrone levels. In a pilot study, a total of 31 urine samples were obtained from 11 subjects, aged 14 to 18 years. A follow-up study was conducted on 26 girls, aged 14 to 19 years, who were randomly selected from an ongoing study of oral contraceptive compliance. Subjects were given an oral contraceptive (Ortho-Novum 1/35), combined with 28 mg of riboflavin. In both studies, urinary fluorescence tests for riboflavin and self-reports were found to be significantly associated. In the follow-up study, both self-reports and urinary fluorescence tests were significantly associated with serum norethindrone levels. When the urinary fluorescence test agreed with self-report, compliance or noncompliance was confirmed by serum norethindrone levels in 90% of the cases. The findings suggest that riboflavin, combined with self-report, can be used as an accurate and cost-effective indicator of adolescent compliance with oral contraceptives.

Adolescent↗
PubMed1982

Therapeutic choices made by patients with end-stage cancer.

The Oklahoma Children's Memorial Hospital Oncology Service has developed a new approach for its patients with end-stage cancer. The emphasis is on the patients' acknowledgement of the progression of the disease and the imminence of death, and informed choice between the use of research drugs and no further chemotherapy. Forty-three patients between 6 and 20 years of age participated in a conference of this type. The results demonstrated that they understood that their health was declining. They decided about further therapy autonomously or together with their family. The majority of children who chose supportive care without chemotherapy and lived for a period of time, participated in activities at home as far as their state of health permitted. Severe depression and severe behavioral problems occurred rarely. There was evidence that this open approach enabled patients and family members to communicate openly with each other.

Adolescent↗
PubMed1982

The influence of a family history of CHD risk factors on serum lipoprotein levels in black children and adolescents.

This study evaluated the influence of a family history of coronary heart disease (CHD) and CHD risk factors on the total serum cholesterol/high density lipoprotein (TChol/HDL) and the low density lipoprotein/HDL (LDL/HDL) ratios of 84 black children (ages 7-11 years) and adolescents (ages 12-15 years). Fasting lipid determinations were measured on all subjects. A questionnaire was administered to each subject's parent to determine the frequency of myocardial infarction, heart disease, hypertension, stroke, atherosclerosis, diabetes, and obesity in first- and second-degree blood relatives. Based on three-way analysis of variance tests, significant stroke and age, diabetes and age, and obesity and age interactions in TChol/HDL and LDL/HDL were found. There was also an obesity and age and sex interaction effect on T.Chol/HDL. The results indicated that a family history of stroke, diabetes, or obesity can have an unfavorable effect on the TChol/HDL and LDL/HDL ratios in black adolescents.

Adolescent↗
PubMed1982

Juvenile rheumatoid arthritis.

Juvenile rheumatoid arthritis, the most common connective tissue disease occurring during childhood, is characterized by chronic arthritis and may be associated with disability and blindness. The presentation, laboratory findings and prognosis of the disease differ significantly from those of adult rheumatoid arthritis. Current classification includes systemic, pauciarticular and polyarticular types, each having different therapeutic and prognostic implications.

Adolescent↗
PubMedDate not supplied

Theory building in nurse-midwifery. The care process.

Identifying what it is about the way nurse-midwives care for women that might contribute to healthy outcomes for women and infants requires clear definition of that care process. This article describes our efforts to define the theoretical construct of the nurse-midwifery care process. These efforts culminated in the development of a middle range descriptive theory of nurse-midwifery care. We share those efforts with others in the hopes of encouraging dialogue and the testing of this theory in a variety of clinical settings.

Ethics, Nursing↗