Biomedical subjects
S Jarnum
Publications and source records attributed to S Jarnum.
Fecal radioiodide excretion following intravenous injection of 131-I-albumin and 125-I-immunoglobulin G in chronic inflammatory bowel disease. An aid to topographic diagnosis.
Simultaneous studies with 131-I-albumin and 125-I-immunoglobulin G (IgG) were made in 48 cases of chronic inflammatory bowel disease. Twenty-one had ulcerative colitis and 27 had Crohn's disease which was confirmed at laparotomy in every case. Intestinal protein loss was measured simultaneously by means of 59-Fe-iron dextran in 44 patients. All patients had abnormal intestinal protein loss. A high correlation was shown between fecal 59-Fe clearance and fractional catabolic rate of albumin, confirming the validity of 59-Fe-iron dextran as a test substance to measure intestinal protein loss. Fecal radioiodide excretion of 131-I from 131-I-albumin (A) and 125-I from 125-I-IgG (G) was significantly different in ulcerative colitis and Crohn's disease. The ratio G/A was close to unity (smaller than 1.60) in ulcerative colitis and Crohn's disease with exclusive or predominant involvement of the colon, whereas it was high in Crohn's disease of the small intestine and highest in cases with jejunal involvement. Thus, the ratio may be valuable in topographic diagnosis of chronic inflammatory bowel disease. A high ratio was found in 2 patients with Crohn's disease of the small intestine and normal radiography of the small intestine, and a low ratio was present in 7 cases of ulcerative colitis with normal radiographic findings. In all 9 patients with normal radiography, fecal 59-Fe clearance was elevated as evidence of abnormal intestinal protein loss. No correlation was present between the size of protein loss and the pathoanatomic extent of the lesions on subsequent laparotomy in 25 patients with Crohn's disease. Fecal radioiodide excretion (131-I from 131-I-albumin and 125-I from 125-I-IgG) was positively correlated with diarrhea (daily stool mass) in both ulcerative colitis and Crohn's disease. Intestinal protein loss was not.
Intestinal disaccharidases in Greenland Eskimos.
Jejunal biopsies from 19 adult Greenland Eskimos were studied regarding disaccharidases, two intracellular beta-galactosidases, and morphological appearance. Fifteen of the patients (79%) had low lactase activity, and 3 of these (16%) had sucrase-isomaltase deficiency as well. Two patients had low trehalase activity. Microscopical appearance was essentially normal in all the biopsies, except for a certain stromal plasma cell infiltration. All the patients with low lactase activity had a measurable residual activity of brush border lactase, which was localized in the middle and apical parts of villi, as normally seen for digestive enzymes. Lysosomal acid beta-galactosidase and cytosol hetero beta-galactosidase were not altered. In the patients with sucrase-isomaltase deficiency there was a complete absence of active sucrase-isomaltase complex. The residual maltase, as well as the very weak residual isomaltase, was exerted exclusively by the heat stable maltases (maltase II and III). The material is the first one in which multiple, but not generalized disaccharidase deficiencies are demonstrated.
Treatment with elementary diet in gastrointestinal disease.
Experiences with Vivasorb in the treatment of gastrointestinal diseases are reported. The author successfully treated severe cases of Crohn's disease and distal ulcerative colitis. In severe total ulcerative colitis, marked improvement with Vivasorb could be achieved in only one of three cases. The administration also proved successful in one case of agnogenic chronic diarrhea. No effect could be achieved in two patients with internal and external bowel fistulae, nor in three patients with short bowel syndrome in the immediate postoperative phase.
[Clinical effect of salazosulfapyridine (salazopyrin) in Crohn's disease. A controlled double-blind investigation].
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[Synthetic diet (astronaut food)].
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Nutrition of medical patients.
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The clinical effect of salazosulphapyridine (Salazopyrin r) in Crohn's disease. A controlled double-blind study.
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Incidence of postoperative complications in patients subjected to surgery under steroid cover.
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Short bowel syndrome following resection for Crohn's disease.
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High dose prednisone treatment in severe ulcerative colitis.
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[Lactose malabsorption in West Greenland].
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[Small intestinal exclusion in obesity. Experience with 3 types of operation].
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Intestinal shunt-operation in obesity. A comparison of three types of operation.
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Sucrose malabsorption in Greenland.
In a population study on the western coast of Greenland the incidence of sucrose malabsorption was estimated by means of sucrose tolerance tests in 190 persons. Small-intestinal disaccharidase activity was estimated in 19 patients. Sucrose malabsorption was present in 10.5% of the cases studied-a surprisingly high figure and much higher than the incidence reported elsewhere in the world. This incidence is, however, lower than that of lactose malabsorption in Greenland Eskimos (54%). In contrast to lactose malabsorption, sucrose malabsorption is present from birth; this may have important clinical implications since chronic diarrhoea and malnutrition are fairly common during infancy in Greenland.