Biomedical subjects
Publications and source records attributed to S Jalava.
In 101 patients treated for knee joint hydrops with intra-articular osmic acid injection, an increased incidence of proteinuria and microscopic haematuria was noted on the first day after injection. This increase subsided rapidly and had disappeared 3 days after the injection. Three patients showed transient glycosuria. No signs of permanent renal damage appeared in any patient.
Naproxen levels in serum, synovial fluid and synovium of eighteen patients with "classical" or "definite" rheumatoid arthritis and chronic knee effusion were studied. After oral administration of 250 mg naproxen twice daily, naproxen levels in synovial fluid were found to be more than half as high as in serum. Even in synovium itself naproxen levels were appreciable.
Gold treatment was initiated in 98 patients suffering from early-stage rheumatoid arthritis. In 30 patients side effects due to gold therapy were seen during the first follow-up year: proteinuria in 6, allergic symptoms in 23, and thrombocytopaenia in one patient. The serum IgM level was higher in patients with side effects. None of the 33 other parameters studied showed any significant differences between patients with or without side effects.
Cephalexin (1 g) was administered orally every 6 hours to 13 patients with rheumatoid arthritis and chronic knee effusions without bacterial arthritis. Samples were taken from blood, synovial fluid, synovium, cartilage and bone. The concentrations found in these samples after one oral dose were high enough to have a possible therapeutic effect in bacterial arthritis sensitive to cephalexin.
A total of 62 rheumatoid knee joints were treated with intra-articular 90Y. Results were assessed by clinical, roentgenologic and thermographic examination after a six-month follow-up. The majority of the joints had moderate roentgenologic manifestations of RA before treatment. The roentgenologic stage of the disease did not change during the follow-up period. The thermographic heat emission pattern was pathologic in all cases prior to treatment. The clinical cure and improvement in the thermographic pattern were in agreement in 44 of 50 completely examined cases (88%). The thermographic pattern was unchanged or worse in six knees with a clinically satisfactory anti-inflammatory response. This is probably due to remaining deeper inflammatory activity or to the relatively short observation period of six months, during which time only the clinical symptoms disappeared, while hyperthermy based on increased vascularity remained. The thermographic pattern remained pathologic in all knees without a clinical response to 90Y. Thermography is a safe and reliable complementary method for recording the anti-inflammatory effect of irradiation synovectomy on rheumatoid knees.
Lyaluronic acid and total protein concentrations in synovial fluid of the knee joint obtained from 48 patients with classical or definite rheumatoid arthritis were determined before, and 1 week, 1 month and 6 months after intra-articular injection of 90Y resin colloid. The concentration ratio of total protein to hyaluronic acid, which is a sensitive index of the abnormality of the synovial fluid, was worse a week after the injection in each group as regards the clinical effect of the 90Y resin injection, but was better 1 month and 6 months after the injection only in the remission group.
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