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Biomedical subjects

S J Watt

Publications and source records attributed to S J Watt.

24 records · Page 2Linked to original sources
PubMed1981

Influence of sympatholytic drugs on the cardiovascular response to isometric exercise.

1. The effects of single oral doses of various sympatholytic drugs on the heart rate and blood pressure increases during isometric handgrip contraction were studied in six healthy subjects. 2. Bethanidine reduced both the systolic and diastolic increases in pressure. Clonidine reduced the systolic but not the diastolic increase. Oxprenolol alone or in combination with phentolamine or phenyoxybenzamine failed to influence the pressor response. 3. The increase in systemic blood pressure associated with sustained contraction of voluntary muscle appears to be relatively resistant to acute sympathetic adrenoreceptor blockade in man.

Adult↗
PubMed1981

The treatment of idiopathic orthostatic hypotension: a combined fludrocortisone and flurbiprofen regime.

We report our experience in the management of idiopathic orthostatic hypotension using the prostaglandin synthetase inhibitor, flurbiprofen. In five subjects with proven autonomic failure the effect on blood pressure of the addition of flurbiprofen (or fludrocortisone) to the previous drug regime was assessed. Both lying and standing blood pressure were seen to rise with fludrocortisone treatment although the change in standing blood pressure was not statistically significant. Flurbiprofen, in contrast, produced no change in lying blood pressure but a significant rise in standing blood pressure. Digital blood flow measurements were made on three subjects before and after flurbiprofen and a dose-related reduction in post-occlusive reactive hyperaemia was demonstrated suggesting an effect of this drug on precapillary smooth muscle tonus. Two patients failed to maintain a long-term response to treatment with flurbiprofen and fludrocortisone but have been helped by the addition of I) ephedrine or II) tyramine an monoamine oxidase inhibitor (phenelzine). We recommend a stepwise approach to treatment in this condition commencing with flurbiprofen and adding fludrocortisone later if necessary. This approach would appear to offer the maximum benefit with a minimum of side effects.

Adolescent↗
PubMed1980

A comparative trial of fixed ratio beta-adrenoceptor blocker and diuretic combination products in moderate hypertension.

Two fixed ratio combination tablets, 10 mg pindolol combined with 5 mg clopamide and 100 mg metoprolol combined with 12.5 mg hydrochlorothiazide, were compared at two dose levels in a double-blind crossover trial in 10 previously untreated hypertensive patients. No significant difference was observed between resting blood pressure on the two combinations at either dose level. Exercise systolic pressure was lower after the pindolol/clopamide combination at low dose (p less than 0.05). The incidence of side-effects in this trial was high but proper comparison of the two products could not be made because of the small number of patients. It is suggested that combination products should be used only after patients have failed to respond adequately to a single agent.

Adrenergic beta-Antagonists↗