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Biomedical subjects

S J Schultenover

Publications and source records attributed to S J Schultenover.

7 recordsLinked to original sources

Evaluation of the atypical squamous cell Papanicolaou smear.

The indicated clinical evaluation of atypical squamous cells demonstrated on Papanicolaou (Pap) smear has not been determined. Although several reports and opinions suggest that these cells are of no particular significance other studies have noted these cells in instances of advanced cervical dysplasia. A study of 429 patients with a recent Pap smear demonstrating atypical squamous cells was conducted. Abnormal colposcopy was present in 237 (55%). In 86 (36%) of the 237 patients, dysplasia was confirmed histologically. The authors would, therefore, recommend colposcopy and biopsy of abnormal areas in these patients. A summation of the repeat Pap smear findings of these dysplasia-proven patients is presented.

Adolescent↗

Nephrogenic adenoma of bladder: a report of 8 cases.

Nephrogenic adenoma is an uncommon lesion of the urinary tract. Current information supports a metaplastic transformation of urothelium as the origin of this tumor. Our experience with 8 additional cases confirms the benign behavior of this lesion.

Adenoma↗

Needle aspiration biopsy: role and limitations in surgical decision making.

A total of 464 fine-needle aspiration biopsy specimens in 450 patients was studied. The majority of these aspirates were performed by the pathologist. The technic was 95% sensitive, 99.5% specific, and 97.0% accurate when correlated with histopathology or long-term follow-up. The complication rate was 0.9% and occurred only when needles larger than #22 were used to aspirate lung lesions resulting in pneumothorax. A flow chart for the role of needle biopsy in investigating masses of various organs is presented, together with some illustrative examples. In the current atmosphere of cost-containment, this inexpensive yet fast and accurate technic should play an important role in surgical decision making. However, pathologists and clinicians should be aware of the limitations and should not hesitate in obtaining an open biopsy when necessary, particularly when clinical suspicion for malignancy is not confirmed by the aspiration, in view of the small but significant (4.9%) false-negative rate.

Aged↗

Pulmonary pseudolymphoma.

Pseudolymphomas of the lung are extremely rare with approximately 30 cases reported in the literature. Histologically it may be impossible to distinguish a benign pseudolymphoma from a malignant lymphoma. Immunoperoxidase staining has been proposed to help predict the benign or malignant potential of these conditions. Results thus far have been inconclusive, but a monoclonal pattern has tended to predict malignant potential. We have reported a pulmonary pseudolymphoma that failed to stain with the immunoperoxidase technique due to improper tissue fixation. After four years of clinical follow-up, the patient remains disease free.

Aged↗

Lymph node aspiration biopsy. Diagnostic reliability and limitations--an analysis of 350 cases.

The results of fine needle aspiration biopsy of lymph nodes in 350 patients and the modified biopsy technique used at our institution are discussed. Of the 350 cases, 209 aspirates were categorized as cytologically malignant, 102 as benign, 30 as suspicious for malignancy, and 9 as unsatisfactory. Cervical lymph nodes were most commonly sampled (58%), and supra-clavicular nodes were most likely to be malignant (90%). The overall diagnostic accuracy achieved was 94%. One false-positive and 9 (2%) false-negative results were observed in the 350 cases. In 3% of the 30 cases diagnosed as suspicious for malignancy, follow-up open biopsy of the lymph nodes in question proved them benign. The advantages and limitations of the procedure are discussed, as well as some of the possible sources of error, particularly in the diagnosis of lymphomas.

Biopsy, Needle↗

Hyaline-cell pleomorphic adenoma. Diagnosis by fine needle aspiration biopsy.

The cytologic, histologic, immunohistochemical and ultrastructural characteristics are presented of a case of hyaline-cell pleomorphic adenoma of the soft palate diagnosed by aspiration biopsy. Hyaline cells are commonly found in pleomorphic adenomas of minor salivary gland origin. The lack of cohesiveness of the hyaline cells makes them readily amenable to sampling by fine needle aspiration biopsy. When identified in a neoplasm, these cells are characteristic, and probably diagnostic, of a mixed tumor.

Adult↗