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Biomedical subjects

S J Roberts

Publications and source records attributed to S J Roberts.

At least 109 records · Page 6Linked to original sources

Social support and help seeking: review of the literature.

This article reviews the literature on social support/network and help seeking. The review suggests that the network is important in transmitting values and beliefs that influence health behaviors, in providing treatment and referral for disorders, and in alleviating or causing stress that leads to the use of services. Although there is a great deal of theoretical writing and research that substantiates the relationship of social supports to help seeking and evidence that nurses in practice are providers of support, there is very little research on nursing interventions that provide support. The article argues that one of the reasons for the lack of tested interventions is the lack of an adequate typology for categories of lack of support. The article argues that, because different categories require different types of interventions, development and testing of interventions can be assisted by a typology. Six categories of lack of support are proposed. Interventions are discussed for each category.

Crisis Intervention↗

Regulation of binding of phosphofructokinase to myofibrils in the red and white muscle of the barred sand bass, Paralabrax nebulifer (Serranidae).

The binding of phosphofructokinase (PFK) to myofibrils from the white muscle of the fish Paralabrax nebulifer (Girard, 1854) is sensitive to factors known to be allosteric regulators of PFK activity. PFK in Triton-X-100-extracted muscle remains bound to myofibrils at pH 7.0 and is fully solubilized by increasing the pH to 8.0. The curve describing the pH-dependence of PFK binding to myofibrils is similar in its steepness to pH versus activity curves of PFK at low temperature. Nucleotides are also potent modulators, preventing the association of PFK with myofibrils at concentrations between 20 and 60 mumol l-1 of ATP, ADP, MgATP or GTP, listed in order of effectiveness. PFKs in the red and white muscle extracts differ in their pH-dependence of binding to myofibrils, and their kinetic and regulatory properties (response to citrate, pH and fructose-2,6-bisphosphate). Reversible binding of PFK to myofibrils may be important in the control of glycolysis, especially in the highly glycolytic white muscle fibres.

Animals↗

Preliminary validation of a nurse-patient interaction tool.

This paper presents initial data on the development and validation of a Nurse-Patient Interaction Tool. Factor analysis of this 44-item Likert-type scale yielded two major factors, Control vs Powerlessness and Agreement with Plan. These factors showed adequate reliability and utility in assessing responses of patients to varying styles of nurse-patient interchanges in a simulated health-care setting. Further validation is necessary to explore its usefulness with various patient populations.

Attitude to Health↗

Scrotal hernia in rams. A case report.

Scrotal hernia in rams is relatively rare. This report would indicate the condition is probably inherited as a recessive character similar to other domestic animals.

Animals↗

Enhancing self care through active negotiation.

The concept of self care, increasingly popular over the last decade, is based on a return of individual power and control. The use of an active negotiation process can increase the client's participation and sense of control, thus enhancing self care. A three-phase active negotiation model is presented that suggests specific behaviors that nurse practitioners can use to facilitate client involvement in decisions about their care.

Humans↗

Binding of phosphofructokinase to filamentous actin.

Phosphofructokinase (PFK) and filamentous actin from rabbit skeletal muscle form a specific association as demonstrated by electron microscopy of the negatively stained proteins. Actin paracrystals have distinct cross-striations when PFK is present. The periodicity of these striations, 37 +/- 1.0 nm, corresponds to the crossover spacing of the actin helix, 36 +/- 1.0 nm. Assays based on the sedimentation of actin indicate that PFK binds to actin in a concentration-dependent manner with no indication of saturation at a PFK:actin ratio 33 times higher than the ratio in mammalian skeletal muscle. This binding is maintained at physiological ionic strength. Increasing the pH from 6.7 to 7.5 causes a gradual elution of PFK from purified actin filaments. The binding of PFK to actin decreases the rate and extent of activity loss caused by the dissociation of PFK tetramers at low pH and low temperature. The reversible association of PFK with actin may play a role in regulating PFK activity and, therefore, glycolysis during periods of metabolic acidosis.

Actins↗

Prognostic variables in endometrial carcinoma.

Data were obtained retrospectively on 1005 patients with histologically proven endometrial carcinoma from January 1960 to December 1976 inclusive. The 5- and 10-year actuarial survivals for all stages were 83 and 80% respectively. Recurrent disease developed in 14% of patients. The site of first recurrence was vaginal vault in 2.5%, lower vagina in 1.1%, pelvis in 5.7%, and lungs in 1.9%. Thirty-eight patients (27%) had multiple sites of metastatic disease at the time of first relapse. The only significant independent prognostic variables for clinical Stage I adenocarcinoma treated with surgery and radiation were no myometrial penetration and poorly differentiated tumors.

Adenocarcinoma↗

Curative radiotherapy for stage IV carcinoma of the penis.

We report the case of a patient with locally-advanced penile cancer and metastatic inguinal adenopathy who has been cured by radiotherapy. In an era when chemotherapy is being advocated increasingly for the control of locally-advanced penile cancer, our surprisingly good result is a timely reminder that high-dose radiotherapy alone can be a worthwhile therapeutic option.

Adult↗

Absence of two membrane proteins containing extracellular thiol groups in Rhnull human erythrocytes.

Rhnull human erythrocytes lack all the antigens of the Rhesus blood-group system and are associated with mild chronic haemolytic anaemia. These erythrocytes have an abnormal shape and increased osmotic fragility. Labelling studies with the impermeant maleimide N-maleoylmethionine [35S]sulphone show that Rhnull erythrocytes lack two extracellular thiol-group-containing membrane components of apparent mol.wts. 32 000 and 34 000. Immunoprecipitation with mouse monoclonal antibody R6A (which reacts with all normal erythrocytes, but fails to react with Rhnull erythrocytes) specifically precipitates the 34 000-mol.wt. component from normal erythrocytes. Similar studies with human anti-Rh(D) serum shows that this antibody reacts with the 32 000-mol.wt. component. The results suggest that the R6A-binding polypeptide and the Rh(D) polypeptide may be involved in the maintenance of the shape and viability of the human erythrocyte.

Chemical Precipitation↗

The dysmenorrhea personality: actuality or statistical artifact?

A group of 31 women who were experiencing severe dysmenorrhea were matched by age with a group of 31 women who had no dysmenorrhea symptoms. Women in both groups took the 16PF. Some major methodological and statistical flaws found in previous research of this type were corrected. The results convincingly showed that 16PF personality profiles for the two groups were extremely similar. Finally, there were no indications of any personality abnormalities.

Adult↗

The relationship between early and late gastrointestinal complications of radiation therapy for carcinoma of the cervix.

In a retrospective analysis of 1,390 consecutive patients with carcinoma of the cervix treated by high dose radiation therapy alone at the Queensland Radium Institute, we report a quantitative relationship between the early and late gastrointestinal complications arising from such treatment. Of these 1,390 patients, 157 (11.3%) experienced early, serious complications. For geographic reasons, it was only possible to evaluate 784 patients for late post-irradiation complications. Twenty-eight (3.6%) developed one or more late bowel complications, which included adhesions, fistulae, strictures, perforation, colitis and vascular occlusion. Factors affecting the relative risk of developing either an early or late complication were analyzed and are discussed. There was an 8.2% incidence of late complications developing in those patients who had experienced early complications, compared with a 3.0% incidence of late complications developing in patients without early complications. Thus, the risk of developing a late complication was greater by a factor of 2.7 in those patients developing an early one (p less than 0.05). However, of the 28 patients developing late complications, 21 (75%) did not experience a severe acute one.

Adult↗

A review of twinning in horses and the possible therapeutic value of supplemental progesterone to prevent abortion of equine twin fetuses the latter half of the gestation period.

Equine twinning, related abortion and progestogen plasma concentrations during the gestation period were reviewed. The supplemental administration of exogenous progesterone apparently prevented impending twin abortions in three mares after midgestation. A single viable twin and a mummified fetus were delivered at term by the mares.

Abortion, Veterinary↗

Properties of N-maleoylmethionine sulphone, a novel impermeant maleimide, and its use in the selective labelling of the erythrocyte glucose-transport system.

1. The synthesis of N-maleoylmethionine sulphone (MMS), a membrane-impermeant protein-labelling reagent, is described. Radioactively labelled MMS can be readily prepared at high specific radioactivity from [35S]methionine. 2. The permeability of the erythrocyte membrane to the reagent was assessed by determining the extent of inactivation of glyceraldehyde 3-phosphate dehydrogenase after treatment of erythrocytes with MMS. Some inactivation of this enzyme was found when high concentrations (20mM) of the compound were used, but this could be prevented by pretreatment of the erythrocytes with 4,4'-di-isothiocyanatostilbene-2,2'-disulphonic acid, suggesting that MMS slowly enters the cells via the anion-transport system. 3. Treatment of erythrocytes with [35S]MMS resulted in the labelling of six major components. Labelling of erythrocyte membranes resulted in the intense labelling of many additional components. 4. MMS inhibited erythrocyte glucose transport. Cytochalasin b protected glucose transport against inactivation by MMS. Labelling experiments in erythrocytes in the presence and in the absence of cytochalasin b showed that the cytochalasin b-protected material was a broad band in the band-4.5 region.

Biological Transport↗

Psychological and social evaluation in cases of deliberate self-poisoning seen in an accident department.

The outcome in 115 consecutive patients with mild self-poisoning seen by junior medical staff and discharged from the accident department was compared with that of 98 similar patients admitted to the medical wards. Psychiatrists saw only four patients in the accident department and 25 admissions. In making their assessments the junior medical staff considered psychosocial factors as well as the patients' physical condition. Most patients recommended for further care, and discharged from the accident department, subsequently received it. Repetition rates were similar in the two groups and there had been no suicides when patients were followed up at one year. It is feasible for junior staff in an accident department to decide whether patients with self-poisoning need admission or may be discharged with or without subsequent referral for psychiatric or social work help.

Emergency Service, Hospital↗