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Biomedical subjects

S J Mork

Publications and source records attributed to S J Mork.

5 recordsLinked to original sources
PubMed1994

Tumour volume reduction following gamma knife radiosurgery: the relationship between X-ray and histological findings.

The case histories of two young ladies with Cushing's disease are described. Both patients were treated first with Gamma Knife radiosurgery and subsequently by microsurgery. The radiosurgery caused a marked reduction in tumour volume but only a partial relief of the endocrinopathy. Comparison of the histological findings with the radiological findings following radiosurgery indicates that confluent necrosis is not a prerequisite for a reduction in tumour volume. It seems more likely that the reduction in tumour volume is related to changes in cellular dynamics.

Adenoma↗
PubMed1988

Trans fatty acids. 1. Growth, fertility, organ weights and nerve histology and conduction velocity in sows and offspring.

Effects of dietary trans fatty acids on the pre- and postnatal growth and development in pigs were studied with special emphasis on nervous tissue. In experiment 1, female pigs were fed partially hydrogenated fish oil (PHFO) (28% trans) or soybean oil (PHSBO) (36% trans), in comparison with lard (0% trans) from weaning (3 wk) through the first reproduction cycle (up to 2 yr). In experiment 2, female pigs were fed two fish oils (33 and 19% trans) in comparison with coconut oil (0% trans) in diets with low and high levels of linoleic acid (18:2n-6 cis, cis) from gestation until their offspring were three wk old. Compared with the trans-free fats, the trans-containing fats had no effect on growth and development, feed consumption and utilization or on the weight of the brain, heart, kidneys, liver, lungs or spleen in the adult sows and their offspring. No effects from the experimental fats were found on histology and conduction velocity of the peroneal nerve. An increased number of the sows fed PHFO had fertility problems compared with those fed lard and PHSBO in Expt. 1, but no similar effects were seen in Expt. 2. It is concluded that consumption of trans fatty acids with 18-22 carbon atoms from PHFO and with 18 carbon atoms from PHSBO at levels that were 5 to 12 times higher than those normally consumed by humans had no detrimental effects on female pigs or their offspring during pregnancy and lactation.

Animals↗
PubMed1985

Composite cerebral neuroblastoma and astrocytoma. A mixed central neuroepithelial tumor.

This report describes an exceptional example of cerebral neuroblastoma in association with neoplastic glial cells, which were frequently arranged in clusters around the supporting blood vessels. The neuroblastic nature of the tumor was confirmed by the presence of numerous dense-core vesicles in the cell processes. The glial nature of the associated cells was confirmed by their positivity for glial fibrillary acid protein by immunoperoxidase staining and by the presence of abundant cytoplasmic filaments of intermediate size on electron microscopy. Of particular interest was the presence of dense-core vesicles in some of the glial cells, and that of a basal lamina underlying the perivascular glial cells. The tumor was interpreted as a composite cerebral neuroblastoma and astrocytoma. No undifferentiated neuroepithelial stem cells could be identified. The cytogenesis of this mixed neuroepithelial neoplasm is uncertain.

Astrocytoma↗
PubMed1977

Ependymoma: a follow-up study of 101 cases.

One hundred and one patients with histologically confirmed ependymomas were studied over a 22-year period. Choroid plexus papilloma and sub-ependymoma were not included. About half of the tumors were intracranial, with the majority of these infratentorial. The intraspinal tumors were equally divided between intramedullary and the "cauda" group. The majority of the intracranial tumors occurred in children, while almost all the intraspinal tumors were in adults. The histologic classification consisted of "typical ependymoma" (cellular, papillary and myxopapillary patterns) and "anaplastic ependymoma". The intracranial and intramedullary tumors showed a predominantly cellular pattern, while the myxopapillary type was found only in the "cauda" group. The histology seems to be of limited value in assessing the prognosis in an individual patient with ependymoma. The postoperative prognosis was poor in the intracranial tumors, although radiotherapy increased the survival time without affecting the eventual fatal outcome. The prognosis in the intraspinal group was much better, with three-fourths of the patients living for at least 10 years. No patient with an anaplastic tumor survived for more than 6 years.

Adolescent↗