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S J Judge

Publications and source records attributed to S J Judge.

At least 19 recordsLinked to original sources

Reflection makes sense of rotation of the eyes.

Our 3-D percept of the world is constructed from the two-dimensional visual images on the retina of each eye, but these images and the relationships between them are affected by the 3-D rotations of each eye. These 3-D eye rotations are constrained to patterns such as Listing's law, or its generalisation 'L2', according to the context. Our understanding of the patterns of such three-dimensional eye rotations, and their effect on the retinal images, has been greatly advanced by the development of algebraic methods (Haustein, 1989; Tweed & Vilis, 1987; Westheimer, 1957) for calculating the effect of eye rotations. But not many would say, with Dirac, that they understand the equations describing the 3-D geometry in the sense that they have "a way of figuring out the characteristic of its solution without actually solving it" (Dirac, according to Feynman, Leighton, & Sands, 1964). I show here how the geometry of 3-D rotations of the eye and their visual effects can be made easier to understand by use of the principle that a rotation through angle alpha can be achieved by a pair of reflections in planes with an angular separation alpha/2, and a common line that is the rotation axis (Tweed, 1997b; Tweed, Cadera, & Vilis, 1990). Mathematically (see Appendix A), the method is equivalent to decomposing the unit quaternions so successfully used to study three-dimensional eye rotations (Tweed & Vilis, 1987; Westheimer, 1957) into pairs of pure quaternions (ones whose scalar part is zero) which represent the reflections (Coxeter, 1946).

Biomechanical Phenomena↗

Can reliable values of Young's modulus be deduced from Fisher's (1971) spinning lens measurements?

The current textbook view of the causes of presbyopia rests very largely on a series of experiments reported by R.F. Fisher some three decades ago, and in particular on the values of lens Young's modulus inferred from the deformation caused by spinning excised lenses about their optical axis (Fisher 1971) We studied the extent to which inferred values of Young's modulus are influenced by assumptions inherent in the mathematical procedures used by Fisher to interpret the test and we investigated several alternative interpretation methods. The results suggest that modelling assumptions inherent in Fisher's original method may have led to systematic errors in the determination of the Young's modulus of the cortex and nucleus. Fisher's conclusion that the cortex is stiffer than the nucleus, particularly in middle age, may be an artefact associated with these systematic errors. Moreover, none of the models we explored are able to account for Fisher's claim that the removal of the capsule has only a modest effect on the deformations induced in the spinning lens.

Adolescent↗

Numerical modelling of the accommodating lens.

Data on geometric and material properties of the human lens derived from various published sources are used to construct axisymmetric, large displacement, finite element models of the accommodating lens of subjects aged 11, 29 and 45 years. The nucleus, cortex, capsule and zonule are modelled as linearly elastic materials. The numerical model of the 45-year lens is found to be significantly less effective in accommodating than the 29-year lens, suggesting that the modelling procedure is capable of capturing at least some of the features of presbyopia. The model of the 11-year lens shows some anomalous behaviour, and reasons for this are explored.

Accommodation, Ocular↗

Modelling the mechanics of accommodation and presbyopia.

Finite element methods have been used to compute the expected relationship between changes in ciliary body diameter and the change in refractive power implied by the change in geometry of the human ocular lens, using values for the material properties and initial geometry taken from the literature (notably the slit lamp photography of Brown (1973) and the studies by Fisher (1969) of the lens material properties). The results show that if the non-linearity associated with the changing geometry is taken into account the lens does not respond to ciliary body stretch by an increase in power [as recently claimed by Schachar et al. (1993), but in the conventional way with a decrease in power. The models show a decrease in the amplitude of accommodation between the age of 29 and 45 years (using Brown's data, 1973), but using Brown's data for the 11-year-old eye leads to the paradoxical conclusion that accommodation amplitude in this eye would have been small. In the process of carrying out the modelling, we have examined the consistency of the published measurements and also the validity of the mathematical methods used in interpreting them, and this analysis suggests that further work is needed before one can be confident that the assumptions about geometry and material properties on which the modelling is based are sound.

Accommodation, Ocular↗

Compensatory changes in eye growth and refraction induced by daily wear of soft contact lenses in young marmosets.

Several studies have shown that growth of the primate eye responds in a compensatory direction to both positive and negative spectacle lenses--eyes grow more slowly and become hyperopic in response to positive lenses, and eyes grow more rapidly and become myopic in response to negative lenses. On the other hand, extended wear soft contact lenses, whether positively or negatively powered, induce hyperopia (Hung & Smith, 1996. Extended-wear, soft, contact lenses produce hyperopia in young monkeys. Optometry & Vision Science 73, 579-584.). We investigated whether responses in a compensatory direction occurred to soft contact lenses worn on a daily wear basis (8 h per day on an 8:16 h light:dark cycle). Ten infant marmosets (8-13 weeks of age) wore a soft contact lens, in one eye only, for 5-9 weeks. Lens powers used were zero (n = 2), +2 D (n = 1), +2 D followed after 5 weeks of lens wear by +4 D (n = 1) for 4 weeks, +4 D (n = 2), -2 D followed after 5 weeks of lens wear by -4 D (n = 2) for 4 weeks, -4 D (n = 2). At the end of the lens-wear period the positive lens-wearing eyes were more hyperopic relative to the fellow untreated eyes [mean +2.39 +/- 0.24 D (SE)] and the negative lens-wearing eyes were more myopic than the fellow untreated eyes [mean -2.48 +/- 0.91 D (SE)]. Fellow eyes were unaffected by lens wear [mean final refraction +0.45 +/- 0.09 D (SE)]. Plano lenses did not affect eye growth in either marmoset fitted with plano contact lenses.

Analysis of Variance↗

Overnight lens removal avoids changes in refraction and eye growth produced by plano soft contact lenses in infant marmosets.

Infant marmosets were fitted with zero-powered (plano) soft contact lenses from 4 to 8 weeks of age worn either continuously (24 h per day) (n = 4), for 12 h (n = 4), or for 8 h (n = 3) per day to determine whether limiting the daily duration of lens-wear could significantly reduce or eliminate the effects of continuous lens-wear on ocular growth and refractive state. As in macaques (Hung, L. F., & Smith, E. L. (1996). Extended-wear, soft, contact lenses produce hyperopia in young monkeys. Optometry and Vision Science, 73, 579-584), eyes fitted with contact lenses worn continuously developed more hyperopic refractions (mean +3.22 +/- 1.49 D SE) compared to their fellow untreated eyes, inconsistent changes in vitreous chamber depth (-0.02 +/- 0.09 mm SE) and flatter corneas (mean decrease in corneal power 4.22 +/- 0.39 D SE). Eyes wearing lenses for only 12 h per day showed similar but reduced effects compared to the 24-h group. Most importantly, ocular growth, corneal power and refraction were unaffected in the 8-h group. Future studies using contact lenses in infant primates should employ a reduced daily duration of lens-wear to eliminate the undesirable effect of contact lens-wear per se on ocular development.

Analysis of Variance↗

Normal development of refractive state and ocular component dimensions in the marmoset (Callithrix jacchus).

Refractive state and ocular dimensions were studied longitudinally in nine normal marmosets. Animals were anaesthetised and examined (with some exceptions) at 4, 6, 7, 8, 10, 15, 24 and 39 weeks of age. Cycloplegic retinoscopy showed that hyperopia early in life rapidly diminished. Refraction corrected for the artefact of retinoscopy stabilised by 8 weeks of age, but at a slightly myopic value, rather than at emmetropia. The ocular components continued to change throughout the period studied. Corneal radius, measured by photokeratometry, increased slightly during development. Anterior segment depth and vitreous chamber depth (VCD), measured by A-scan ultrasonography, increased throughout development while lens thickness initially increased and then decreased. Data from the eyes of these normal animals were compared with that from the contralateral eyes of animals which received short periods of monocular deprivation early in life (Troilo, D., & Judge S.J. (1993). Ocular development and visual deprivation myopia in the common marmoset (Callithrix jacchus jacchus). Vision Research, 33, 1311-24); eyes which viewed through no lens or a plano lens (Graham, B. & Judge, S.J. (1999)). The effects of spectacle wear in infancy on eye growth and refractive error in the marmoset (Callithrix jacchus). Vision Research, 39, 189-206), and eyes of normal animals in another colony. There were no significant differences between the first two groups and the normal animals in our colony while age-matched animals from the other colony were slightly but significantly less myopic than our animals.

Animals↗

The effects of spectacle wear in infancy on eye growth and refractive error in the marmoset (Callithrix jacchus).

We made a comprehensive study, involving observations on 45 marmosets, of the effects on ocular growth and refraction of wearing spectacles from the ages of 4-8 weeks. This period was within the period early in life when the eye grows rapidly and refraction changes from hyperopia to its adult value of modest myopia. In one series of experiments we studied the effect of lenses of powers -8, -4, +4 and +8D fitted monocularly. In another series of experiments we studied the effect of lenses of equal and opposite powers fitted binocularly, with the two eyes alternately occluded, so as to give an incentive to use both eyes, and in particular to accommodate, for at least part of each day, through the negative lens. The vitreous chamber of eyes that wore negative lenses of -4D or -8D, combined with alternate occlusion, elongated more rapidly than that of the fellow eye (negative lens eye-positive lens eye, 0.21 +/- 0.03 mm (S.E.M.), P < 0.01 and 0.25 +/- 0.06 mm, P < 0.05, respectively) and became relatively more myopic (2.8 +/- 0.26D, P < 0.01 and 2.4 +/- 0.61D, P < 0.05 respectively). Eyes that wore -4D lenses monocularly elongated more rapidly and became myopic than fellow eyes. Eyes that wore +4D or +8D lenses were less strongly affected: animals that wore +8D lenses monocularly (without alternate occlusion) developed a slight relative hyperopia (0.99 +/- 0.21D, P < 0.01), with the more hyperopic eyes also slightly shorter (0.09 +/- 0.05 mm) than their fellow eyes, but eyes wearing +4D lenses were not significantly different from their fellow eyes. Animals that wore -8D lenses monocularly (without alternate occlusion) developed a slight relative hyperopia after three weeks of lens-wear (0.85 +/- 0.26D, P < 0.05). These were the only eyes that responded in a non-compensatory direction to the optical challenge of spectacle wear, and we interpret this effect as one due to visual deprivation. After the removal of lenses, the degree of anisometropia slowly diminished in those groups of animals in which it had been induced, but in the three groups in which the largest effects had been produced by lens-wear the overall mean anisometropia (0.68 +/- 0.24D, P < 0.01) and vitreous chamber depth (VCD) discrepancy (0.09 +/- 0.03 mm, P < 0.01) were still significant at the end of the experiments, when the animals were 273 days old. The reduction of anisometropia in these groups was associated with an increase in the rate of elongation of the vitreous chamber in the eyes that had previously grown normally i.e. the less myopic eyes grew more rapidly than their fellow eyes: in the seven weeks following lens-wear these eyes became more myopic and longer than normal eyes (refraction P < 0.001; VCD P < 0.001). Control experiments showed that occlusion of one eye for 50% of the day had no effect on eye growth and refraction, and therefore that alternate occlusion itself had no effect.

Age Factors↗

Mechanics of accommodation of the human eye.

The classical Helmholtz theory of accommodation has, over the years, not gone unchallenged and most recently has been opposed by Schachar at al. (1993) (Annals of Ophthalmology, 25 (1) 5-9) who suggest that increasing the zonular tension increases rather than decreases the power of the lens. This view is supported by a numerical analysis of the lens based on a linearised form of the governing equations. We propose in this paper an alternative numerical model in which the geometric non-linear behaviour of the lens is explicitly included. Our results differ from those of Schachar et al. (1993) and are consistent with the classical Helmholtz mechanism.

Accommodation, Ocular↗

How is binocularity maintained during convergence and divergence?

The geometrical requirements for binocular fusion are stated, and the main features of horizontal vergence eye movements are described, together with an influential schema of understanding the interaction between vergence and accommodation. The anatomy and physiology of the midbrain region implicated in vergence and accommodation control are discussed. The cortical areas from which suitable sensory signals might be derived are mentioned briefly, and a speculation is made about esotropia.

Animals↗

Visual optics and retinal cone topography in the common marmoset (Callithrix jacchus).

The common marmoset (Callithrix jacchus) is a small, diurnal, New World monkey amenable to vision research. In this paper we describe the visual optics and cone photoreceptor topography of the normal adult marmoset. Paraxial optical ray-tracing shows that the marmoset eye is well represented as a scaled-down version of the human eye. The density of foveal and perifoveal cone photoreceptors in the marmoset is as high, and in peripheral retina higher, than those reported in humans and macaques. The foveal acuity predicted by the Nyquist limits set by the cone mosaic (30 c/deg) is in agreement with behavioral measures of visual acuity. Foveal depth of focus is remarkably small (< 0.2 D) for an eye of this size (axial length about 11 mm). Estimates of the amplitude of accommodation using infrared photorefraction indicate that the marmoset is capable of more than 20 D of accommodation.

Animals↗

Ocular development and visual deprivation myopia in the common marmoset (Callithrix jacchus).

The normal postnatal ocular development of the common marmoset (Callithrix jacchus) and the effects of visual deprivation on eye growth and refractive state are described. The marmoset normally undergoes a developmental process of emmetropization from high hyperopia at birth. This emmetropization is easily disrupted by visual deprivation produced by lid-suture. Myopia and axial elongation of the vitreous chamber are induced by visual deprivations of 12, 5, and 3 weeks duration. The development of axial myopia after 3 weeks of visual deprivation differs from longer duration deprivations in that the experimental eyes are initially shorter than normal and hyperopic at the end of the visual deprivation period, but subsequently become longer than normal and myopic. Visual deprivation myopia in the marmoset persists even after the deprivation is discontinued and a visual signal is restored. In all experimental groups, the development of the eye in response to the cessation of visual deprivation shows no slowing of vitreous chamber enlargement; the axial enlargement relative to the control eye is either maintained or increases and produces significantly greater myopia. These results suggest that the visual control of postnatal eye growth in the marmoset may be unidirectional in its response to visual experience and able only to increase the growth rate of the vitreous chamber, possibly after an initial delay.

Animals↗

Role of monkey midbrain near-response neurons in phoria adaptation.

1. One striking characteristic of the way in which accommodation and convergence of the eyes are organized is that although the two responses are usually tightly coupled, a brief period of binocular viewing through prisms that require extra convergence brings about a persistent, adaptive alteration in the relationship between the two responses: the vergence during monocular viewing of a target at a given distance is biased in a convergent direction. We sought to discover the role of the near-response neurons we have previously described in the monkey midbrain in such phoria adaptation. 2. Phoria adaptation was produced in two monkeys by having them view binocularly stereoscopic targets under conditions that mimicked prism viewing, i.e., the mirrors of the stereoscope were set so as to require more convergence than that associated with a real target at the same distance as the images seen in the stereoscope. The activity of 57 near-response neurons located dorsally and dorsolaterally to the oculomotor nucleus was recorded before and after adaptation while the monkeys monocularly viewed targets at a range of distances. 3. Comparison of a neuron's response in normal binocular viewing with the response when the accommodation and vergence stimuli were in conflict allowed us to distinguish 24 neurons that behaved as though they were related exclusively to the vergence response. 5 neurons that behaved as though they were exclusively related to the accommodation response, and 12 neurons whose firing was not so simply related to either response. We were unable to classify the remaining 16 near-response cells by this method. 4. In accommodation-related neurons, the relationship between firing rate and accommodation did not alter, or only altered slightly, when the animal's phoria was adapted. 5. The relationship between firing rate and vergence was unaltered by phoria adaptation in only a small proportion of vergence-related neurons, showing that most neurons do not carry the entire signal responsible for phoria adaptation. On the other hand, in the majority of vergence-related neurons the relationship between firing rate and accommodation was altered by phoria adaptation, showing that most neurons do carry part of the phoria adaptation signal. 6. The implication is that the increase in vergence observed after adaptation is mediated at more than one site. A proportion of the phoria adaptation signal is present at the level of the midbrain vergence-related neurons, with the remainder of the signal being added later, presumably at the motoneurons.

Accommodation, Ocular↗

Binocular interactions in accommodation control: effects of anisometropic stimuli.

In binocular viewing of real targets, the accommodative demand in the two eyes is not in general identical, yet the accommodation response in the two eyes is equal. In order to investigate how the accommodative signals from the two eyes are combined, this study has examined the effects of several forms of dynamic anisometropic stimulation on the accommodation response in both man and the rhesus monkey (Macaca mulatta). All experiments were performed in a computer-controlled haploscopic apparatus to allow independent control of the accommodative stimuli to the two eyes and of the vergence stimulus. The vergence stimulus was held constant while the accommodation demand was modulated independently in each eye. Accommodation was monitored continuously with a dynamic infrared optometer. Four anisometropic conditions were used. In two of these conditions, accommodation demand was varied sinusoidally with time in both eyes, but with phases differing by 90 degrees or 180 degrees between the two eyes. In the two remaining conditions, accommodation demand in one eye varied sinusoidally, while the accommodation demand was constant in the other. In all cases, the form of the target pattern was identified in the two eyes. The accommodation responses observed with these stimulus conditions were similar in both man and the monkey. When presented with conflicting stimuli in the two eyes, the accommodation response appeared to be best described as a compromise between the inputs to the two eyes; there were no indications of a purely random alternation of eye dominance of the form seen in binocular contour rivalry. When the accommodation demand was modulated in only one eye, there was a modulated accommodation response of similar phase to the control condition (i.e., both eyes modulated in phase) but with a much smaller gain (mean, 39% of control gain). When the accommodation demand was modulated in both eyes with a phase difference of 180 degrees, no significant modulation was observed in the accommodation response at the stimulation frequency. When the interocular phase difference was 90 degrees, a modulated response was observed that showed a mean phase lag 41 degrees more than that observed in the control condition (both eyes modulated in phase) and an appreciably smaller gain (mean, 55% of control gain). The extent to which the results can be described by a linear vector average of the uniocular inputs is considered.

Accommodation, Ocular↗

Do target angular size-change and blur cues interact linearly in the control of human accommodation?

Calculations made using the data of Kruger and Polar [J. opt. Soc. Am. A2, 1832-1835 (1985); Vision Res. 26, 957-971 (1986); Vision Res. 27, 555-567 (1987)] show that for three of the four subjects they studied, size-change and blur cues do not interact linearly in the control of accommodation. A simple non-linear interaction model is shown to fit the data for all four subjects.

Accommodation, Ocular↗