Trends in cancer therapy and patient survival, 1940 to 1959.
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Humans↗
Biomedical subjects
S J Cutler
Publications and source records attributed to S J Cutler.
Evaluation of three commercial tests for Lyme disease.
A commercial indirect immunofluorescence assay (IFA), enzyme-linked immunosorbent assay (ELISA), and a passive hemagglutination kit were evaluated and compared with our in-house IFA and ELISA methods. Both IFA methods gave identical results but were less sensitive than ELISA methods. Likewise, the ELISA methods were comparable. The hemagglutination method gave a statistically significant difference when compared with our ELISA method (p = 0.018 McNemar test). It is recommended that the passive hemagglutination method should not be used in its current state.
Antibodies, Bacterial↗
Factors associated with morbidity and mortality among patients on CAPD.
Since 1981, the National CAPD Registry, sponsored by the National Institute of Arthritis, Diabetes, Digestive, and Kidney Diseases of the National Institutes of Health, has been systematically collecting demographic and follow-up data on patients receiving continuous ambulatory peritoneal dialysis (CAPD) as maintenance therapy for end-stage renal disease. Using life-table methods, this study has identified the association of diabetic glomerulosclerosis with age over 60 or under 20 years as factors jointly relevant in predicting peritonitis, hospitalization, or death. In addition, these outcomes were more likely to occur if patients were black and had been exposed to other dialytic therapy earlier on. The latter two were the only factors jointly predictive of transfer from CAPD onto hemodialysis. Careful monitoring of patients with the above mentioned characteristics may reduce complications, and lead to greater success with this increasingly popular dialysis modality.
Adult↗
The 1987 USA National CAPD Registry report.
The National CAPD Registry has noted encouraging trends in CAPD therapy in the U.S. Recently, trained patients have reported lower peritonitis rates, fewer days hospitalized for dialysis-related events, and lower probability of developing a first episode of a complication. If accumulating experience, better patient selection, and new technologic developments further these trends, then the relatively high transfer rates should begin to decrease since many transfers are related to peritonitis and other complications. The Registry's observations suggest that CAPD is an evolving therapy and that as complication rates and transfer rates decrease, CAPD may play an even greater role in the treatment of patients with end-stage renal disease.
Female↗
Correlates of personal concerns about developing Alzheimer's disease among middle-aged persons.
We examine correlates of personal concerns about developing Alzheimer's disease (AD) among (1) adult children, 40 to 60 years of age, who have a living parent with a diagnosis of probable AD (N = 108), and (2) a matched comparison group of persons with no parental history of AD (N = 150). Using stepwise regression, predictors measuring subjective perceptions of memory functioning, overall family history of AD, knowledge of AD, and sociodemographic characteristics were entered into models for the total sample and each of the subsamples. The results indicate that worries about memory functioning play a consistent role in personal concerns about developing AD across both groups, but that additional pathways to personal concerns differ among individuals having and not having a parent with AD.
Adult↗
Safety on the streets: cohort changes in fear.
Using data from two national surveys, cohort changes in fear for one's safety on the streets are examined over an eleven year period. Fear of walking alone at night has increased among all cohorts, but the greatest increases have taken place among the older cohorts. These results are consistent with interpretations that stress characteristics of the aging process to account for the elderly's greater fear of vulnerability to criminal victimization.
Adult↗
Trends in the management of cancer.
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Breast Neoplasms↗
Classics in oncology. Survival in untreated and treated cancer.
During 1935 to 1951, a total of 75,494 cancer cases occurred among the inhabitants of Connecticut, of whom there were 2,000,000 in 1950. The five-year survival rate has improved gradually from 12 and 19 percent of all males and females, respectively, in 1935 to 1940, to 20 and 32 percent, respectively, during 1947 to 1951. This improvement is not due to earlier diagnosis of the cases, as can be seen from the similar distribution of localized and disseminated cases during the whole period of study. The improvement has occurred in cancer that is diagnosed when it is clinically localized and when it involves regional areas, but not when it is disseminated. The most marked improvement is recorded for cancers of the colon and rectum in both sexes, and of the uterine cervix in women. The data are compared with survival rates anticipated in untreated neoplastic disease. A new era of detection and treatment of cancer is being entered through the studies on in situ and occult cancers among the population.
Adult↗
Lyme borreliosis: an update.
Lyme borreliosis is now known to be associated with a variety of different genospecies of spirochaetes. The resulting clinical picture may vary according to which genospecies is causing the infection. Multiple infection with other agents may complicate the diagnosis.
Borrelia burgdorferi Group↗