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Biomedical subjects

S J Crews

Publications and source records attributed to S J Crews.

At least 37 records · Page 2Linked to original sources
PubMed1984

The qualitative comparative analysis of the visual field using computer assisted, semi-automated and manual instrumentation: II. Statistical analysis.

A comparative evaluation of the Octopus automated perimeter (Programmes 21 and 31), the Goldmann Bowl perimeter, the Bjerrum Screen and the Friedmann VFAs MkI and MkII was carried out on a heterogeneous sample of 75 patients. The results for the sample as a whole were analysed statistically in terms of the scoring system developed by Flanagan, Wild, Barnes, Gilmartin, Good and Crews (1984a). Statistically significant differences between the instruments were found at each of the 4 levels of analysis.

Adolescent↗
PubMed1984

The qualitative comparative analysis of the visual field using computer assisted, semi-automated and manual instrumentation: III. Clinical analysis.

A comparative evaluation of the Octopus automated perimeter (Programmes 21 and 31), the Goldmann Bowl perimeter, the Bjerrum Screen and the Friedmann VFAs Mk I and Mk II was carried out on a heterogeneous sample of 75 patients. Field loss was categorized using a modification of the classifications proposed by Greve (1982). The results were analysed using the Level 4 analysis developed by Flanagan, Wild, Barnes, Gilmartin, Good and Crews (1984a). The performance of the various test logics was found to differ between the categories of field defect.

Computers↗
PubMed1984

A study of retinitis pigmentosa in the City of Birmingham. I Prevalence.

Using multiple sources, an attempt was made to ascertain all symptomatic cases of retinitis pigmentosa living in the City of Birmingham in June 1978. These methods revealed a prevalence for all ages of 1 in 4869 and a prevalence in the age group 45 to 64 years of 1 in 3195. There was a higher prevalence than expected among young Muslims with consanguineous parents. However, the most accurate prevalence of uncomplicated retinitis pigmentosa among adults was considered to be that found in an outpatient clinic serving adult diabetics, namely, six patients in a clinic population of 8000 to 10 000.

Adolescent↗
PubMed1984

A study of retinitis pigmentosa in the City of Birmingham. II Clinical and genetic heterogeneity.

This is a study of 138 index patients with retinitis pigmentosa (RP) and their families, in which the selection of index patients was solely on the basis of their residence in Birmingham. Clinical analysis showed that severe disease was as likely to indicate dominant or non-genetic RP as to indicate recessive disease, and that each of three genetic types of uncomplicated RP could probably be divided into two entities. Autosomal dominant RP accounted for at least 22% of index patients but this was likely to be an underestimate because of the low penetrance of the disease. Autosomal recessive disease accounted for not more than 10% of index patients and its rarity was indicated by a high consanguinity rate. Recognisable X linked disease occurred in about 14% of index patients, a similar figure to other studies. The 37% of patients with uncomplicated RP and no obviously affected relative have either autosomal dominant RP or non-genetic RP; it is difficult to know the relative proportions of each. The risks for descendants of patients with recessive disease are clear. The risks of symptomatic RP in the offspring of patients who do, or who might have, dominant RP range from 1 in 2 to 1 in 37 according to the family history and the severity of the RP.

Adolescent↗
PubMed1983

DNA probes in X-linked retinitis pigmentosa.

Informative members of more than twenty families with X-linked retinitis pigmentosa have been sampled by venipuncture and DNA extracted from peripheral blood leucocytes and lymphoblastoid cell lines. X chromosome-specific recombinant DNA probes have been isolated from an X chromosomal genomic DNA library obtained by flow-sorting human chromosomes. These, and similar probes obtained from other laboratories, are being used to identify restriction fragment length polymorphisms in retinitis pigmentosa obligate heterozygotes. By analysis of linkage relationships in the offspring of double heterozygotes, it may be possible to localize the gene(s) responsible for this disorder to a particular subregion of the X-chromosome. Such probes are potentially useful for carrier detection and prenatal diagnosis.

Adolescent↗
PubMed1979

HLA antigens and certain types of uveitis.

Some preliminary results are given on human leucocyte antigen (HLA) typing of nine patients with sympathetic ophthalmitis, two with Vogt-Koyanagi-Harada disease, and nine with Behçet's disease and uveitis. In the sympathetic ophthalmitis patients the relative risk for B40 was 7.2, which would indicate that a more extensive study might be valuable. In Behçet's disease B5 and B27 both carried increased risks of 9.4 and 11.1 respectively.

Behcet Syndrome↗
PubMed1979

Psychophysical and visual evoked potential findings in hereditary optic atrophy.

24 members of families with dominant hereditary optic atrophy were investigated. Visual acuity, Goldmann perimetry, Farnsworth-Munsell 100-hue tests, and visual evoked potentials to flash and pattern-reversal were performed. All except the Goldmann perimetry showed a significant association with the presence of optic atrophy. The flash VEP showed a positive-negative-positive response in most of the affected patients.

Adolescent↗
PubMed1978

Electroretinography with noncorneal and corneal electrodes.

The noncorneal ERG is essential for certain patients in which corneal recording is contraindicated. A preliminary report is presented investigating ERGs from three noncorneal montages and their correlation with the corneal ERG. Statistical analysis showed that an electrode at the medial canthus combined with medial viewing gave the closest correlation to the corneal ERG. Repeatability was good for all montages. The inner canthus electrode was considered preferable for noncorneal recording because it was less affected by other time-locked activity; it correlated well with the corneal ERG and can be used in conjunction with the electro-oculogram.

Adolescent↗
PubMed1975

Electrodiagnosis and ultrasonography in the assessment of recent major trauma.

This paper reports a prospective study of 47 eyes with opaque media after recent major ocular trauma which were assessed by measurement of visual acuity, electroretinography, visually evoked response, and ultrasonography. The results of each method of assessment were analysed as indiced of prognosis for visual recovery. Each method of examination proved of value for prognosis, and a combined assessment using all the methods together was of special value.

Adult↗