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S J Cooper

Publications and source records attributed to S J Cooper.

246 records · Page 14Linked to original sources
PubMed1976

Exploratory response habituation and the attenuating effect of an amphetamine-barbiturate mixture.

Mutual potentiation between dl-amphetamine (0.75 mg/kg) and amylobarbitone (15.0 mg/kg) can occur, measured as a marked increase in locomotor exploratory responses in the rat (Rushton and Steinberg, 1963). Experiment 1 confirms the potentiation between amphetamine and amylobarbitone, and extends the finding to a distinctly different type of exploratory behaviour (the 'head-poke' response). However, the same amphetamine-barbiturate mixture did not affect the preference for responses rewarded by a light-onset contingency (Expt. 1), and also did not affect the threshold of a response elicited by aversive footshock (Expt. 2). The mixture may facilitate the occurrence of exploratory responses by a direct attenuation of the rate of habituation of the exploratory responses, and not secondarily by altering the reward or aversion of external stimuli, or by changing the animal's level of arousal.

Amobarbital↗
PubMedDate not supplied

The relationship between clinical and biochemical changes following neuroleptic treatment in schizophrenia.

Clinical improvement in psychotic symptoms is not immediate when neuroleptic treatment is commenced. Previous studies have demonstrated the development of biochemical tolerance to the effects of neuroleptics on the dopamine system. This study demonstrates a relationship between this biochemical change and the clinical changes occurring in the patients. The results can be explained in terms of dopamine receptor changes in a way that is compatible with the Dopamine Hypothesis for schizophrenia.

Adolescent↗