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S J Bryant

Publications and source records attributed to S J Bryant.

11 recordsLinked to original sources
PubMed1990

Factors affecting the concentrations of ferritin in serum in a healthy Australian population.

We measured by different techniques the ferritin concentration in serum in two large asymptomatic Australian population samples: 1367 bank employees and 601 insurance corporation employees. Ethanol intake, diet, the frequency of blood donation, smoking and exercise habits, and past medical history were documented. The median concentration of ferritin in serum varied according to age and sex, but was generally higher than in previously reported populations under age 65 years. Results for the two population samples were in close agreement. Apart from the blood donation status, the most important factors influencing the concentration of ferritin in serum were ethanol intake in men and diet in women. Heavy ethanol intake was associated with increased values, even among men without evidence of liver disease. We conclude that the reference range for ferritin concentration in serum in the Australian population should be significantly increased and should be related to age as well as sex. This study emphasizes the need to determine local reference ranges for ferritin concentrations in serum.

Adult↗
PubMed1986

Reference intervals for calcium, phosphate, and alkaline phosphatase as derived on the basis of multichannel-analyzer profiles.

In an attempt to demonstrate a rapid and economical approach to deriving reference intervals, we analyzed data on plasma calcium and phosphate from a multichannel analyzer for more than 20 000 subjects and data on alkaline phosphatase from more than 10 000 subjects. Subjects were selected by the criterion, that their results for constituents other than the one of interest were within current reference intervals. Thus we have been able to include older patients who have diseases that accompany old age, but that do not affect test results. The mean concentrations of calcium and phosphate decreased with increasing age in both sexes, except for an abrupt increase for women about the time of reaching menopause. Similarly, the mean alkaline phosphatase activity increased with age in both sexes, reflecting a skewed frequency distribution. Here also, there was an abrupt increase in the modal value for women near menopause.

Adult↗
PubMed1976

Xylose-1-14C absorption test: the use of urine, serum and breath analysis, and comparison with a colorimetric assay.

The xylose absorption and excretion test has been reassessed in controls and patients with coeliac disease. Xylose has been assayed in both serum and urine colorimetrically and by liquid scintillation counting using xylose-1-14C. The excretion of 14CO2 in breath following administration of xylose-1-14C has been measured. Liquid scintillation counting is a simple and reliable method for the measurement of xylose absorption. Serum xylose levels, urinary xylose excretion, or breath 14CO2 in isolation were poor screening tests for mucosal disease. The use of serum levels and urinary excretion in combination improved the discriminatory value of the test though small gut biopsy was more reliable.

Carbon Dioxide↗
PubMed1975

The effect of multiphasic biochemical screening on the diagnosis of primary hyperparathyroidism.

Experience of primary hyperparathyroidism (PHPT) at the Royal Brisbane Hospital was reviewed to determine the effect of multiphasic biochemical screening, introduced during 1970, on the rate of diagnosis of this disease. In the period 1959-1970, there were 28 proved cases and, in the period 1971-1974, 41 cases, an increase from 2.5 to 11.7 cases per annum. The main factor contributing to this increase was the inclusion of plasma calcium in the multiphasic screening programme, together with correction of the plasma calcium for the total protein concentration in the same blood sample.

Blood Proteins↗
PubMed1967

Hyaline droplet formation in the renal epithelium of patients with haemoglobinuria.

Renal hyaline droplet formation is described in two patients with haemoglobinuria. The droplets were shown to contain haemoglobin by a histochemical method. The findings are correlated with the results of recent experimental studies which have demonstrated that renal hyaline droplets are phagosomes containing absorbed protein and not products of cellular degeneration as was previously thought.

Adult↗