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Biomedical subjects

S Ivanov

Publications and source records attributed to S Ivanov.

At least 37 records · Page 2Linked to original sources
PubMed2005

[Choice of delivery method in preeclamptic patients].

The represented study is made in order to prove whether the mode of delivery influences the perinatal prognosis of neonates born with preeclamptic mothers, appreciated by pH and the Apgar score at the 5-th minute. There are 544 preeclamptic patients included in the study, admitted to Majchin dom hospital, between 1995 and 2004. The comparison between the mean Apgar and mean pH, demonstrated no difference between neonates delivered through Cesarean Section and neonates delivered through vaginal delivery.

Apgar Score↗
PubMed2005

[Association between the protein loss and the perinatal outcome in preeclamptic pregnant women].

Proteinuria is one of the two main criteria for the diagnosis of preeclampsia. But except an important diagnostic it is also an important prognostic factor of the maternal perinatal outcome. 544 pregnant women were enrolled in a prospective study between 1995 and 2005. Of all of them the protein loss was measured by a qualitative or quantitative assay. It was ascertained that the higher protein loss was associated with a lower fetal birth weight and lower 5 minute Apgar score no matter of the laboratory test type. These data suggest that the protein loss in preeclampsia could be used as a prognostic not only for the maternal, but also for the fetal perinatal outcome.

Apgar Score↗
PubMed2005

[Ferro-folgamma--a good alternative in the treatment of iron deficiency anemia and depleted iron stores in pregnant women].

OBJECTIVE: To study the effect of different therapeutical regimens of Ferro-Folgamma, in pregnant patients with iron deficiency anemia. MATERIALS AND METHODS: 22 pregnant patients between 20 and 35 week of gestation (mean 29 gestational week) with hemoglobin levels between 83.1-106 g/l were included. They were divided in two groups: group 1 included patients with hemoglobin levels up to 100g/l and group 2--with hemoglobin levels between 100 and 110. The dosage of the preparation in group 1 was 1 tablet Ferro-Folgamma tid for 40 days, and 1 tablet Ferro-Folgamma bid for the same period. Blood samples were taken four times during the study on day 0, 10th day, 20th day and in the week after the 40th completed day of therapy. The samples were tested for CBC, iron, transferine, feritine, folic acid. All patients were given complete information about the possible risks of iron deficiency anemia during pregnancy and parturition. DISCUSSION AND RESULTS: The mean hemoglobin level at initiation of treatment was 91.22 g/l (day 0). After initiation of treatment the the following rise in hemoglobin levels was detected 10th day - 103.8 g/l, 20th day - 112.6 g/l, after the 40th completed day - 136.0 g/l. The mean levels of the rest of hematological parameters were, day 0 - Er - 3.25 mln/microl, Fe - 7.53 micromol/l, transferine - 3.65 gr/l, feritine - 15.02 ngr/ml, folic acid - 14.08 ng/ml, vit. B12 - 219.68 pg/ml; 10th day - Er- 3.5 mln/microl, Fe - 14. 12 micromol/l; 20th day - Er - 4.10 mln/microl, Fe - 20.46 micromol/l; 40th completed day - Er- 4.69 mln/microl, Fe - 13.12 micromol/l, transferine - 3.82 gr/l, feritine - 27.42 ngr/ml, folic acid - 15.67 ng/ml, vit. B12 - 484.52 pg/ml respectively. CONCLUSIONS: Oral treatment with Ferro-Folgamma, according the described dosage regimen, demonstrates its fast and stable effect in treatment of moderate iron deficiency and recovery of depleted iron pool in pregnant patients as well. It could be administered as a prophylactic preparation for borderline anemic states.

Anemia, Iron-Deficiency↗
PubMed2004

[Effect of antioxidants in women with increased risk of preeclampsia. The role of oxidative stress in preeclampsia].

New frontiers have been opened lately in the understanding of the patho-phisiology of preeclampsia thus giving new directions in the process of therapy of this condition. Oxidative stress is a condition characterized by peroxidants predominating over antioxidants. Numerous intensive studies are carried out to reveal the role of oxidative stress in the pathogenesis of preeclampsia.

Antioxidants↗
PubMed2004

[Study of neovascularisation in endometrial cancer and hyperplasia using angio-Doppler technique].

The aim of our research work was to evaluate the neovascularisation in endometrial cancer and hyperplasia of the endometrium using "power" angio-Doppler technique. Two hundred and fifty patients /200 bulgarian and 50 patients from Greece/ with irregular bleeding, as well as women without bleeding in menopause were estimated. Age of the patients ranged between 44 and 80 years. There was not found any neovascularisation in the control group patients with normal histopathological results. The sensitivity of our method was 15% for the endometrial hyperplasia and 84% for the endometrial cancer. The specificity and the positive predictive value was for both 100%. For the endometrial cancer p < 0.06/pulsative index--PI--0.95 +/- 14, resistance index--RI--0.45 +/- 0.09, while for the endometrial hyperplasia--PI--1.40 +/- 0.25 and RI--0.65 +/- 0.20. If we summarize our results using "power" angio-Doppler technique the irregular vascularisation of the endometrium in patients with hyperplasia was found in 14%, while for the women with endometrial cancer was 85%. The analysis of the values of blood flow in the neovascularisation areas of the endometrium for level of significance PI < or = 1.0; RI < or = 5 and time-averaged maximum velocity/TAMV/ > 18 cm, may be a very important element in differentiation of benign from malignant lesions. The transvaginal ultrasonography with "power" angio-Doppler technique may serve as an important diagnostic method for differentiation of endometrial hyperplasia from endometrial cancer especially in the early stages of this malignant disease.

Adult↗
PubMed2004

[Can education duning pregnancy improve the perinatal outcome in diabetic pregnancies?].

UNLABELLED: The aim of the study was to define the role of education for the complex treatment plan of diabetes during pregency and to estimate the impact of education for the reduction of the incidence of maternal and neonatal complications. STUDY DESIGN: A retrospective study of 56 pregnant women with diabetes was carried out. They were hospitalized in the High-risk pregnancy Department from January 1999 till January 2000. All pregnant women were admitted to the hospital in each trimester of pregnancy for control of carbohydrate metabolism and follow-up of pregnancy. All pregnant women were treated by intensified Insulin regime-type basal-prandial. The diet was set according to the needs during pregnancy. 30 pregnant women (group 1) were educated according to the specificity of diabetes during pregnancy. The education was repeated every time the patient was admitted to the hospital. The aim of education was to reach and maintain good metabolic control (HbA1c < 7.5%) in the course of pregnancy. The values of HbA1c before education in group 1 and after final education in group 2 (not educated) were determinated. The incidence of some maternal and perinatal complication-the progress from diabetic nonproliferative retinopathy into proliferative retinopathy, the development of preeclampsia as a causative factor for delivery before 37 g.w, the development of RDS and perinatal deaths were evaluated. RESULTS: There was a significant difference in the mean values of glycosylated Hb. In the group of educated women a good metabolic control was achieved--HbA1c = 7.5%. In the non-educated group the metabolic control was poor--HbA1c = 8.4%, irrespective of the insulin and diet treatment. 25 (84.4%) of the babies born to educated mothers had normal birthweight between 3000 and 4000 grams. 2 (6.6%) of the newborn had birthweight under 3000 gr. and 3 (10%) over 4000 gr. In the group of educated women there was no progress of nonproliferative retinopathy into proliferative type. There was such a progression in 3 women from the noneducated group. There were 22 cases of preeclampsia in both groups. In the group of educated women the preeclampsia was mild, compared to the noneducated group where the form was severe. All women with severe form of preeclampsia (n=8) delivered before 37g. w. There were no perinathal deaths in the educated group, compared to 3 (11.5%) deaths in group 2. 2 babies died antenatally and one after an operative correction for severe congenital heart defect. There were 6 (6.6%) cases of RDS from the educated group compared to 99 (16.6%) from group 2. CONCLUSIONS: The education is a key factor in the complex plan of treatment of pregnant women with diabetes. It creates a positive motivation for the achievement and maintenance of good metabolic control during pregnancy. The incidence of maternal and neonatal complications is higher in the group of non-educated women. The education significantly reduces the incidence of maternal and neonatal complications, thus improving the perinatal outcome.

Blood Glucose↗
PubMed2004

[Diagnostic value of the Doppler ultrasound of kidney vessels in pregnancy complicated with preeclampsia].

Preeclampsia (PE) is a complication of the second half of the pregnancy whose clinical course is hypertension and proteinuria with or without edema. Its pathogenesis is characterized with generalized vasoconstriction and endothelial dysfunction. The aim of this study is to evaluate the diagnostic value of the Doppler ultrasound examination of the renal interlobar vessels in pregnancy complicated with preeclampsia in the context of the theory of the increased vessel resistance in this pregnancy disorder.

Adult↗
PubMed2004

[Results of cytoreductive surgery for advanced and recurrent ovarian neoplasms and papillary serous carcinomas of the peritoneum].

The aim of our study was to review and show the long-term results of the cytoreductive surgery in the treatment of advanced primary and recurrent epithelial ovarian cancers and papillary serous carcinomas of the peritoneum. We wanted to find clinical factors and in this way to select patients who can benefit from this kind of treatment. The clinical data of 32 patients searched retrospectively are presented in our research work. In 29 patients was possible radical cytoreductive surgery. Neoadjuvant and early postoperative chemotherapy were applied in most of the patients. The median follow up after cytoreductive surgery was 50 months. The overall median survival after cytoreduction was 38.5 months. We consider the cytoreductive surgery to be effective only when combined with neoadjuvant or with early postoperative chemotherapy. The surgical approach without chemotherapy leads to bad results.

Adenocarcinoma, Papillary↗
PubMed2004

[Prognostic factors and better survival rate after the treatment of advanced ovarian cancer with neoadjuvant chemotherapy].

The better survival rate was evaluated as well as the prognostic factors due to the treatment with neoadjuvant chemotherapy for ovarian cancers FIGO Stage III and IV. For the period of 1990 till 2004 - 238 patients with histological diagnosis cystadenocarcinomas were evaluated. 192 patients received conventional chemotherapy after surgical treatment and 46 patients were treated with neoadjuvant chemotherapy after which a secondary cytoreductive surgery was used. The five years survival rate for the neoadjuvant chemotherapy was the same as the five years survival rate from the conventional chemotherapy. The patients with residual tumor < or = 2 cm. had a better prognosis than those with residual tumor more than 2 cm. There was a better prognosis for the patients treated with > or = 18 mg/m2/ week cisplatin from those treated with < 18 mg/m2/week.

Antineoplastic Combined Chemotherapy Protocols↗