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Biomedical subjects

S Iu Kasumova

Publications and source records attributed to S Iu Kasumova.

At least 19 recordsLinked to original sources
PubMed1990

[Symptoms of disconnection of cerebral hemispheres and brain stem in severe cranio-cerebral injuries].

Based on an analysis of 56 cases with diffuse axonal lesions the authors describe symptoms of dissociation of the brain hemispheres and brain stem. Such symptoms occur on transformation of long coma to a steady or transitory vegetative state and are characterized by chaotic activation of the subcortical and stem formations remaining intact and dynamic manifestation of a complex of postural and generalized motor reactions, complex pathological reflexes, oral, oculomotor, pupillary and cerebrospinal automatisms, paroxysmal vegeto-visceral abnormalities along with functional silence of the cortex.

Adolescent↗
PubMed1988

[Identification of proteolysis-resistant fragments carrying P-type antigenic determinants in chordin and immunologically related human brain antigen].

An antigen immunologically related to chordin was identified in white and gray matter of large hemispheres of human brain as well as in one of glial tumours. It was shown that human and rabbit brain extract components cross-react with eight monoclonal antibodies directed against chordin-specific epitopes of P-group. Exhaustive proteolysis of giant sturgeon notochord and human brain extracts resulted in fragments interacting with anti-chordin antibodies and eluted in an equal volume during chromatography on TSK HW-40 gel. At the same time, gel electrophoresis performed under denaturing conditions revealed that the mobility of chordin subunits strikingly differs from that of brain antigen immunologically related to chordin. Thus, the cross-reactivity of antichordin antibodies with the human brain extract component is due to the presence in this antigen of a P-type determinant which, after exhaustive proteolysis of both antigens, is detected in structures (presumably, glycopeptides) having an identical molecular mass.

Animals↗
PubMed1986

[Evaluation of comatose states].

The most informative neurological symptoms allowing the differentiation of 7 phases of consciousness disorders have been identified on the basis of clinico-physiological correlations and mathematical processing. In the first phase of coma the patient cannot be waken up. Addition of muscle atonia characterizes the transfer to the second phase of coma and of bilateral mydriasis indicates the transfer to the third phase. Eye opening in response to sound or pain points to awakening and transfer to the phase of apallitic syndrome. The performance of simple instructions is characteristic of the phase of deep stupor. Responses to questions characterize stupor, and recovery of orientation in the environment indicates clear consciousness.

Brain↗
PubMed1983

[Radioimmunoassay in the evaluation of the hormonal activity of pituitary adenomas].

Direct correlation was found between the results of a radioimmunoassay, electron microscopy and immunohistochemistry in cases of STH-secreting and hormonally inactive hypophyseal adenomas. In hyperprolactinemia and a simultaneous increase in the levels of 2 or more hormones the results of the radioimmunoassay coincided with those of electron microscopy and immunohistochemistry in 50-70% of the cases.

Adenoma↗
PubMed1982

[Functional morphology of pituitary adenoma in acromegaly].

Twenty-one pituitary adenomas removed from patients with acromegaly were studied electron microscopically. In 9 cases the tumors underwent immunohistochemical analysis by Coons' indirect immunofluorescent technique. Before the operation, all the patients were found by radioimmunoassay to have concentrations of pituitary hormones in the blood serum. A clinico-morphological analysis performed showed that in all cases of acromegaly pituitary adenoma consisted of somatotropocytes differing by the degree of cell granulation. The concentration of the somatotropic hormone (STH) in the blood serum of the patients did not depend on the intensity of the ultrastructural signs of the secretory activity of the cells. In 4 adenomas, a positive immunohistochemical reaction to two hormones, STH and prolactine, was demonstrated.

Acromegaly↗
PubMed1981

[Immunochemical study of alpha-1 organospecific antigen in different sections of the brain and CNS tumors].

By immunochemical methods the most high concentrations of alpha-1 organ specific antigen of the brain were revealed in tissue extracts of the spinal marrow, cerebral trunk, hypothalamus; its lower concentrations--in the cerebral cortex, cerebellum, optic nerve, white substance of the hemispheres and pineal gland. This protein was not found in the hypophysis. In tumors of neuroectodermal origin the antigen was found in high concentrations. In an group of meningiomas alpha-1 organ specific brain antigen was detected in tumors of meningotheliomatous type, but it was absent in tumors of mixed and fibroblastic type, this permitted suggesting a neuroectodermal origin of tumors of the first type and ectomesenchymal one of the second type.

Alpha-Globulins↗
PubMed1980

[Immunodiffusion analysis of embryonic prealbumin in a tumorous tissue extract].

By immunodiffusion analysis the presence of embryonal prealbumin (EPA) in extracts of different tumors has been studied. EPA is most frequently detected in extracts of bone tumors (75.0%) with the titre up to 1 : 256 and in tumors of soft tissues (74.5%) also with the titre up to 1 : 256. The EPA immunochemical test is believed to be of value for monitoring tumors of the connective-tissue origin.

Bone Neoplasms↗
PubMed1979

[Case of Nelson syndrome].

A clinical description of Nelson syndrome developing in a woman of 44 is presented. Histologically the tumour of the hypophysis was an adenoma of mixed structure, electron microscopically it was found to consist of corticotropocytes in various stages of the secretory cycle. Adenoma of the hypophysis was diagnosed 4 years after bilateral adrenalectomy.

Adult↗
PubMedDate not supplied

[The structural bases of the compensatory potentials of the central nervous system in closed craniocerebral trauma].

The article analyses 160 cases of fatal craniocerebral trauma encountered in the practice of the Burdenko Research Institute, AMS USSR, in 1980-1989. The results of the author's personal research and the literature data bear evidence of the different means of restoration of the functions of the central nervous system in localized and diffuse axonal brain damage. Reparative processes in the neurons of the pericontusion zone may provide compensatory changes. Compensation of disturbed functions of the central nervous system in diffuse axonal trauma is determined to a certain extent by the regenerative possibilities of partly damaged axons.

Adaptation, Physiological↗
PubMedDate not supplied

[The CT-stereotaxic biopsy of brain tumors].

CT-stereotaxic biopsy is a modern method for the diagnosis of intracranial tumors. The histological diagnosis established by means of it makes it possible to choose the most rational tactics of treatment and determine more exactly the indications and contraindications for the operation. The examination was conducted on 219 patients with various brain tumors. Authentic histological information was obtained in 84% of cases, 4 patients died, a stable neurological defect developed in another 2 patients. Some methodical procedures for increasing the informativeness and reducing the risk of complications are discussed. An important component is rapid examination of part of the bioptic material by means of smears for intraoperative appraisal of its representativeness and correction of biopsy targets. Among 73 cases in which smears were examined only in 9 the findings were in disagreement with the data of the traditional histologic study, only in the degree of tumor differentiation in all of them. Stereotaxic biopsy is most expedient in situations in which the tactics and main method of treatment are determined to a greater degree by the histological structure rather than by the localization and the patient's general condition. Such cases account for one fourth of all cases of intracerebral tumors.

Adolescent↗