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Biomedical subjects

S Ishimaru

Publications and source records attributed to S Ishimaru.

At least 127 records · Page 7Linked to original sources
PubMed1983

Cineradiographic evaluation of the convexo-concave Björk-Shiley prosthetic valve in mitral position.

The in vivo function of the convexo-concave Björk-Shiley prosthetic valve implanted in mitral position was evaluated with a simple cineradiographic procedure. The maximum opening angle of the tilting disc, calculated from the maximum and the minimum diameter of the radiopaque marker embedded in the disc when viewed elliptically, was 56 +/- 2 degrees and was not affected by tachycardia up to 160 beats per min. The time required for disc opening was almost the same as that for disc closure, and these times shortened in proportion to increase in pulse rate. Disc rotation, quick or slow, could be observed in all patients. Excellent function of the convexo-concave Björk-Shiley prosthesis was demonstrated by cineradiography. Any dysfunction of the disc opening is easily demonstrable, not only from measurement of the disc's maximum opening angle, but also from evaluation of the distance, on en face view, between the characteristic internal rim disc marker and the small strut delineating the small valve orifice when the disc is fully open.

Adolescent↗
PubMed1983

[Intra-arterial injection of an oily antineoplastic agent in hepatic cancer].

A lymphographic agent, Ethiodol, injected via the hepatic artery was found to remain selectively in the tumor vessels of hepatoma for a long time in our clinic. Taking advantage of this selective continuous peripheral embolization, a lipophilic high molecular anticancer agent, SMANCS (Copolymer of styrene maleic acid conjugated to Neocarzinostatin) dissolved in Ethiodol was administered via the celiac axis or the hepatic artery with Seldinger's method. Anticancer effect was examined by histological findings of specimens removed using hepatic resection (13 cases) and autopsy (1 case) in 14 patients receiving this treatment. Anticancer effect of this treatment became clear through histological findings. In the patients administered SMANCS more than 0.26 mg per 1 cm2 of maximum cut-surface area, complete or widespread necrosis of the tumor occurred, whereas non-cancerous liver tissue remained unaffected.

Adult↗
PubMed1983

[A case of posterior communicating artery aneurysm associated with vascular anomaly of circle of Willis].

The patient, 68 year-old, male, was admitted to our clinic with episode of the second attack of subarachnoid hemorrhage in October, 1979. The cerebral angiogram demonstrated an aneurysm arising from the junction of posterior communicating artery and aberrant origin of the anterior choroidal artery. Additionally, bilateral posterior cerebral arteries were filled only through the anterior circulation via the posterior communicating artery. The patient was successfully operated with clipping of the aneurysm through the pterional approach. The aneurysm arising from the posterior communicating artery itself is exceedingly rare. Incidence, symptom and operative approach were discussed with the review of the literature.

Aged↗
PubMed1981

Haemostatic clot formation at anastomosis of synthetic venous graft in defibrinogenated dogs: a scanning electron microscopic study.

A segment of the inferior vena cava was replaced by an expanded polytetrafluoroethylene graft in 13 dogs. Five of them served as a control group, while the other 8 were moderately or severely defibrinogenated with subcutaneous batroxobin. Plasma fibrinogen decreased to extremely low values throughout the experiment in the defibrinogenated dogs except in the moderately treated group in which it temporarily rose to 0.72-0.87 g/l on the first postoperative day. Scanning electron microscopic observations of the haemostatic clot formed at the anastomoses of the graft revealed no significant morphological differences in platelet adhesion and/or aggregation between the three groups. These findings confirmed that platelets play a key role in primary haemostasis during defibrinogenation. The fibrin network was slightly diminished and only short fibrin filaments could be seen in the moderately and severely defibrinogenated groups respectively. These differences in composition of the clots are discussed in relation to their haemostatic capacity.

Animals↗
PubMed1981

Pseudointima in expanded polytetrafluoroethylene graft implanted in the inferior vena cava of normal and defibrinogenated dogs.

The pseudointimal formation in an expanded polytetrafluoroethylene graft implanted in the canine inferior vena cava was studied by light and transmission electron microscopy. Five of 6 grafts in the control group and all of the 10 grafts in the batroxobin-defibrinogenated group were patent, and provided for the investigation. The thickness of the mural thrombus formed within 3 days was significantly decreased in the severely defibrinogenated dogs, in which the fibrinogen concentration was below 0.40 gm/L, as compared to the controls and the moderately defibrinogenated dogs, in which the fibrinogen concentration was at highest 0.72-0.87 gm/L. In spite of reducing the fibrinogen concentration to unmeasurable levels after 3 days, there was no obvious difference in the process of pseudointimal formation between the moderately defibrinogenated dogs and the controls. In the severely defibrinogenated dogs, loose and spongoid mural thrombus required a longer time to be reorganized.

Animals↗
PubMed1981

Pseudoendothelium formation in expanded polytetrafluoroethylene grafts implanted in the inferior vena cava of normal and defibrinogenated dogs.

The outgrowth of endothelial cells in an expanded polytetrafluoroethylene graft implanted in the canine inferior vena cava was studied by scanning electron microscopy. The adjacent endothelial cells of the vena cava started to invade the anastomotic area three days after the implantation and reached approximately the central part of the 2-cm-long graft after 21 days. There was no obvious difference in the process of endothelialization between the control group and the moderately defibrinogenated group, in which the fibrinogen concentration was at most 0.72-0.87 gm/L. A slight delay in the outgrowth of endothelial cells was noted within the first seven days in the severely defibrinogenated group, in which the fibrinogen concentration was below 0.40 gm/L. After 70 days, all grafts were completely covered by endothelial cells. The structural difference of the mural thrombus resulting from reduced fibrin formation might be a major factor influencing the endothelium formation.

Animals↗
PubMed1978

Hughes-Stovin syndrome. Report of a female autopsy case and review of the literature.

A 37-year-old female with multiple pulmonary aneurysms, thrombotic obstruction of the inferior vena cava and mural thrombosis in the right heart was reported. Arterial blood culture repeatedly examined had been negative. The patient died of massive hemoptysis. This case was equivalent to Hughes-Stovin syndrome and was the first female case of typical Hughes-Stovin synrome. Review of the literature revealed 9 typical cases of this syndrome and 5 atypical cases who had solitary intrapulmonary aneurysm. It was obscure whether the typical cases were essentially different from the atypical ones or not, but the cases with solitary pulmonary aneurysm might proceed to the cases with multiple ones, as shown in this case. Pathogenesis of the syndrome has been controversial. In the present case, development of pulmonary aneurysms seemed to be closely related to thromboembolization derived from venous thrombosis due to artificial abortion.

Adult↗