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Biomedical subjects

S Ishihara

Publications and source records attributed to S Ishihara.

At least 379 records · Page 21Linked to original sources
PubMed1985

[A clinical study of cefoperazone in surgery. Prevention of postoperative infections and transfer into pleural effusion].

A clinical study of cefoperazone (CPZ) in the surgery (on the prevention postoperative infections and transfer into pleural effusion) was conducted to obtain results as follows. As for the blood concentration after a 30-minute drip infusion of CPZ 2 g, it was 115.6 +/- 19.88 micrograms/ml (Mean +/- S.E.) 1 hour after completion of the administration. The biological half-life was 2.16 hours. The pleural effusion concentration of CPZ showed 33.3 +/- 7.86 micrograms/ml 2 hours after completion of the administration, which was enough to inhibit the growth of bacteria isolated from sputum and pleural effusion. The excretion was very slow. As for the effectiveness of CPZ for prevention of postoperative infection, CPZ proved effective in all of 8 cases. Specific side-effects were not observed. Thus, the usefulness of this preparation was confirmed.

Adult↗
PubMed1984

In vivo spin-trap study on anaerobic dehalogenation of halothane.

Radical formation in vivo by anaerobic dehalogenation of halothane is described in this paper. The radicals were stabilized by spin-trapping and assayed by electron spin resonance spectrometry. The radical adducts were formed by inhalation of halothane in vivo and increased with decrease in inspired oxygen concentration. Following administration of the spin-trap, the expired concentration of CF2CHCl and CF3CH2Cl which are the anaerobic metabolites of halothane decreased, but bilious trifluoroacetate which are aerobic did not change. These results strongly suggest that radical intermediates are produced in anaerobic dehalogenation of halothane to CF2CHCl and CF3CH2Cl.

Anaerobiosis↗
PubMed1984

Open-position fixation of bioprostheses for more physiological performance. Fluoroscopic observations of leaflet movements in vivo.

A new model of the stent-mounted porcine aortic bioprosthesis was prepared with 0.625% glutaraldehyde while the valve was partially open. A radiopaque marker was attached to the center of the free margin of each leaflet so that the leaflet movements could be observed in an in vivo testing unit by fluoroscopic cinematography. This valve was compared with a porcine xenograft that currently is available commercially. While the heart was beating, the specially prepared leaflets showed some characteristics that contrasted with those of the currently used bioprosthesis. These features included (1) uniformity versus asymmetry of leaflet excursions under low flow conditions, (2) slower and more gradual closing (actual closing time averaging 536 msec versus 81 msec), and (3) more prolonged period of valve opening, the duration of opening averaging 60% versus 49% of the cardiac cycle. These features support the validity of open-position fixation as a means of further improving xenograft durability.

Animals↗
PubMed1983

Effect of temperature on the arrested heart exposed to a 4-hour ischemia during blood potassium cardioplegia. An experimental study.

This study was undertaken to evaluate the optimal myocardial temperature during a 4-hour ischemia induced by blood potassium cardioplegia (PC). Heart-lung preparations with work load circuit were used as experimental model. 24 mongrel dogs were divided into four groups and two myocardial temperatures (moderate hypothermia, deep hypothermia) and two perfusates (PC with blood, PC without blood) were tested. Parameters used to evaluate the myocardial protection include the coronary sinus blood pH of the initial reperfusion and left ventricular stroke work after resuscitation. In blood PC at moderate hypothermia, deleterious acid metabolites were minimally produced as evidenced by the coronary sinus blood pH (7.221 +/- 0.122) at initial reperfusion, and cardiac function was best recovered in this group. Blood PC at moderate hypothermia allows the heart to tolerate 4 h ischemia without an excessively elevated coronary perfusion pressure during cardioplegic infusion.

Animals↗